EXPRESSION AND CLINICAL SIGNIFICANCE OF INTERCELLULAR ADHESION MOLECULES-1 IN RECTAL CARCINOMA AND COLON MUCOUS MEMBRANE TISSUE_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

FAN Xihong , YIN Geping , SUN Xiaoming , et al.

The Jinan Military General Hospital, Jinan 250031;

Corresponding author：

Keywords：

Rectal carcinoma Intercellular adhesion molecules-1

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Objective To investigate the expression of intercellular adhesion molecules-1 (CD54) in rectal carcinoma and nearby mucous membrane and its clinical significance.
Methods The expression of CD54 in the tumors and the mucous membrane 2cm away from the lesions and on the colon section margin was comparatively studied by flow cytometry in 36 cases with rectal carcinoma.
Results The CD54 expression of rectal carcinomas were 9.79%±5.12%, similar to that of the mucous membrance 2cm distal away from the lesions (Ｐ＞0.05) and more than that of colon section margins and control group(Ｐ＜0.05).
Conclusion CD54 is highly expressed in both the rectal carcinoma and the mucous membrance 2cm distal away from the lesions. CD54 may be used as an important clinical tumor marker for rectal carcinoma and the mucous membrance 2cm away from the lesions may have the tendency for malignancy.

Citation： FAN Xihong,YIN Geping,SUN Xiaoming,et al.. EXPRESSION AND CLINICAL SIGNIFICANCE OF INTERCELLULAR ADHESION MOLECULES-1 IN RECTAL CARCINOMA AND COLON MUCOUS MEMBRANE TISSUE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(3): 155-156. doi: Copy

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1. Sheen Chen SM, Eng HL, Cheng YF, et al. Circulating intercellular adhesion molecule1 (ICAM1) in patients with hepatolithiasis 〔Ｊ〕. Dig Dis Sci, 1996; 41(8)∶1682.
2. Yang SS, Tasai G, Wu CH, et al. Circulating soluble intercellular adhesion molecule1 in type C viral hepatitis 〔Ｊ〕. Hepatogastroenterology, 1996; 43(9)∶575.
3. 尹格平，孙晓明，陈诵芬等. 卵巢肿瘤粘附分子吞噬细胞糖蛋白的测定〔Ｊ〕. 中华妇产科杂志， 1997； 32(6)∶358.
4. 孙晓明，尹格平. 实体瘤组织细胞粘附分子流式细胞研究方法的建立〔Ｊ〕. 中华医学检验杂志， 1997； 20(1)∶9.
5. Nakgoba MW, Sanders ME, Ginther Luce GE, et al. ICAM1 a ligand for LFA1dependent adhesion of B, T and myeloid cells 〔Ｊ〕. Nature, 1988; 331(7)∶86.
6. Pforte A, Schiessler A, Kressentein S, et al. ICAM1 expression on alveolar macrophages and in serum of sarcoidosis patients 〔Ｊ〕. J Clin Lab Immunol, 1995; 46(3)∶125.
7. 蔡军，朱理伟，张镜宇. 直肠癌Kras基因突变和细胞动力学异常〔Ｊ〕. 中国肿瘤临床， 1997； 24(11)∶823.
8. 刘世信，韩洪秋，赵丽中等. 直肠癌远端切除2 cm是安全的吗〔Ｊ〕? 中国肿瘤临床， 1997； 24(5)∶343.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EXPRESSION AND CLINICAL SIGNIFICANCE OF INTERCELLULAR ADHESION MOLECULES-1 IN RECTAL CARCINOMA AND COLON MUCOUS MEMBRANE TISSUE

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