EFFECTS OF SPLENECTOMY ON ANTI-TUMOR IMMUNITY DURING THE INDUCTION OF HEPATOCELLULAR CARCINOMA IN RATS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

QIU Peicai ¹ , CHEN Jisheng. ²

Department of General Surgery, The Central Hospital of Shantou, Shantou 515031;

Corresponding author：

Keywords：

Spleen Splenectomy Anti-tumor immunity Induced liver cancer Animal experimentation

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Objective To study the effect of splenectomy on the anti-tumor immunity in rats with induced hepatocellular carcinoma (HCC).
Methods At the second and fourth month of the induced HCC, the NK cell activity, TNF-α level and total lymphcyte in blood were measured in the group of splenectomy and the control group.
Results There were no different in the total lymphcyte and TNF-α in the blood in two groups, but there were significant difference in the NK cell activity between the group of splenectomy and the control group (Ｐ＜0.05). Conclusion There are some change in the anti-tumor immunity after splenectomy in rats, in which NK cell activity is at low level continuously. TNF-α isn′t affected after the second month after splenectomy.

Citation： QIU Peicai,CHEN Jisheng.. EFFECTS OF SPLENECTOMY ON ANTI-TUMOR IMMUNITY DURING THE INDUCTION OF HEPATOCELLULAR CARCINOMA IN RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(4): 224-225. doi: Copy

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2.	姚榛祥，吴诚义. 脾脏肿瘤〔Ｊ〕. 普外临床， 1989； 4(5)∶313.
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4.	Witting CH, Hultsch E. Effect of splenectomy on Band Tlymphocytes and a benzpreneinduced munine sarcoma 〔Ｊ〕. A Krebforsch, 1978; 92(2)∶267.
5.	邱培才，陈积圣. 脾切除对大鼠诱发性肝癌过程的影响〔Ｊ〕. 现代临床普通外科， 1997； 2(4)∶231.
6.	Llende M, SantiagoDelpin EA, Lavergne L. Immunobiological consequence of splenectomy: a review 〔Ｊ〕. J Surg Res, 1986; 40(1)∶85.
7.	仇登波，黄韬，黄文广等. 脾脏对胃癌患者免疫状态的影响〔Ｊ〕. 中华医学杂志， 1992； 72(6)∶334.
8.	Paolo A. Distribution of natural kill cell activity in peripheral blood, card blood, thymus, lymph nodes and spleen and the effect of in vitro treatment with interferon pregaration 〔Ｊ〕. Clin Immune Immunopath, 1981; 19(1)∶161.

1. Mellemkjoer L, Olsen JH, Linet MS, et al. Cancer risk after splenectomy 〔Ｊ〕. Cancer, 1995; 75(2)∶577.
2. 姚榛祥，吴诚义. 脾脏肿瘤〔Ｊ〕. 普外临床， 1989； 4(5)∶313.
3. Catane R, Schlanger S, Weiss L, et al. Toxicology and antitumor activity of tuftsin 〔Ｊ〕. Ann N Y Acad Sci, 1983; 419(1)∶251.
4. Witting CH, Hultsch E. Effect of splenectomy on Band Tlymphocytes and a benzpreneinduced munine sarcoma 〔Ｊ〕. A Krebforsch, 1978; 92(2)∶267.
5. 邱培才，陈积圣. 脾切除对大鼠诱发性肝癌过程的影响〔Ｊ〕. 现代临床普通外科， 1997； 2(4)∶231.
6. Llende M, SantiagoDelpin EA, Lavergne L. Immunobiological consequence of splenectomy: a review 〔Ｊ〕. J Surg Res, 1986; 40(1)∶85.
7. 仇登波，黄韬，黄文广等. 脾脏对胃癌患者免疫状态的影响〔Ｊ〕. 中华医学杂志， 1992； 72(6)∶334.
8. Paolo A. Distribution of natural kill cell activity in peripheral blood, card blood, thymus, lymph nodes and spleen and the effect of in vitro treatment with interferon pregaration 〔Ｊ〕. Clin Immune Immunopath, 1981; 19(1)∶161.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EFFECTS OF SPLENECTOMY ON ANTI-TUMOR IMMUNITY DURING THE INDUCTION OF HEPATOCELLULAR CARCINOMA IN RATS

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