RESENT STUDY OF PATHOGENESIS IN PORTAL HYPERTENSION_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Jijian

Department of General Surgery, The Second Clinical College, Chongqing University of Medical Sciences, Chongqing 400010;

Corresponding author：

Keywords：

Hyperdynamic circulatory syndrome Endotoxin Cytokines Nitric oxide

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Objective The effects of endotoxin, cytokines, nitric oxide were reviewed in the development of hyperdynamic circulatory syndrome in portal hypertension.
Methods Liceratures of overseas main studies in hyperdynamic circulatory syndrome of portal hypertension in recent 10 years were reviewed.
Results The hyperdynamic circulatory syndrome was found in 30%-50% of patients with cirrhosis and in all animal models of portal hypertension. The research results of the effects of endotoxin, cytokines, nitric oxide in the development of hyperdynamic circulatory syndrome were different.
Conclusion Hyperdynamic circulatory syndrome contribute to the maintenance and aggregation of portal hypertension. Endotoxin, cytokines, nitric oxide may play a role in the development of hyperdynamic circulatory syndrome. Nitric oxide is a more important factor. The effect of other factors is probably mediated by nitric oxide.

Citation： WANG Jijian,GAO Gengwu.. RESENT STUDY OF PATHOGENESIS IN PORTAL HYPERTENSION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(4): 275-277. doi: Copy

1.	LopezTalavera JC, Cadelina G, Olchowski J, et al. Thalidomide inhibits tumor necrosis factor, decreases nitric oxide synthesis, and ameliorate the hyperdynamic circulatory syndrome in portalhypertensive rats 〔Ｊ〕. Hepatology, 1996; 23(6)∶1616.
2.	Stark ME, Szurszewski JH. Role of nitric oxide in gastrointestenal and hepatic function and disease 〔Ｊ〕. Gastroenterology, 1992; 103(6)∶1928.
3.	Colombato LA, Albillos A, Groszmann RJ. Temporal relationship of peripheral vasodilation, plasma volume expansion and the hyperdynamic circulatory state in portalhypertensive rats 〔Ｊ〕. Hepatology, 1992; 15(2)∶323.
4.	Albillos A, Colombato LA, Groszmann RJ. Vasodilatation and sodium retention in perhepatic protal hypertension 〔Ｊ〕. Gastroenterology, 1992; 102(3)∶931.
5.	Suffredini AF, Fromm RF, Parker MM, et al. The cardivascular response of normal humans to the administration of endotoxin 〔Ｊ〕. N Engl J Med, 1989; 321(5)∶280.
6.	Lumsden AB, Henderson M, Kutner MH. Endtoxin levels measured by a chromogenic assay in portal hepatic and peripheral venous blood in patients with cirrhosis 〔Ｊ〕. Hepatology, 1988; 8(2)∶2327Bigatello LM, Broitman SA, Fattori L, et al. Endotoxemia, encephalopathy, and mortality in cirrhotic patients 〔Ｊ〕. Am J Gastroenterol, 1987; 82(1)∶11.
7.	Mehta R, Gottstein J, Zeller WP, et al. Endotoxin and hyperdynamic circulation of partal veinligated rats 〔Ｊ〕. Hepatology, 1990; 12(5)∶1152.
8.	Nishida T, Huang TP, Seiyama A, et al. Endothelin Areceptor blockade worsens endotoxininduced hepatic microcirculatory changes and necrosis 〔Ｊ〕. Gastroenterology, 1998; 115(2)∶412.
9.	Deviere J, Content J, Denys C, et al. Excessive in vitro bacterial lipopolysaccharideinduced production of monokines in cirrhosis 〔Ｊ〕. Hepatology, 1990; 11(4)∶628.
10.	Nawroth PP, Bank I, Handley D, et al. Tumor necrosis factor/cachectin interacts with endothelial cell receptor to induce release of interleukin1 〔Ｊ〕. J Exp Med, 1986; 163(6)∶1363.
11.	LopezTalavera JC, Merrill WW, Groszmann RJ. Tumor necrosis factor: a major contributor to the hyperdynamic circulation in prehepatic protalhypertensive rats 〔Ｊ〕. Gastroenterology, 1995; 108(3)∶761.
12.	Kaneda K, Ekataksin W, Sogawa M, et al. Endothelin1 induced vasoconstriction cause a significant increase in portal pressure of rat liver: localized constrictive effect on the distal segment of preterminal portal venules as revealed by light and electron microscopy and reconstruction 〔Ｊ〕. Hepatology, 1998; 27(3)∶735.
13.	Hartleb M, Moreau K, Cailmail S, et al. Vascular hyporesponsiveness to endothelin1 in rats with cirrhosis 〔Ｊ〕. Gastroenterology, 1994; 107(4)∶1085.
14.	Ohlstein EH, Elliott JD, Feuerotein GZ, et al. Endothelin receptors: receptor classification, novel receptor antagonists, and potential therapeutic targets 〔Ｊ〕. Med Res Rev, 1996; 16(2)∶365.
15.	Cahill PA, MingChin Hou, Hendrickson R, et al. Increased expression of endothelin receptor in the vasculature of portal hypertensive rats: role in splanchnic hemodynamics 〔Ｊ〕. Hepatology, 1998; 28(2)∶396.
16.	Gandhi CK, Sproat LA, Subbotin VM. Increased hepatic endothelin1 levels and endothelin receptor density in cirrhotic rats 〔Ｊ〕. Life Sci,1996;58(1)∶55.
17.	Rockey NC, Chung JJ. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver, endothelial dysfunction in portal hypertension 〔Ｊ〕. Gastroenterology, 1998; 114(2)∶344.
18.	Pizcuta P, Pique JM, Fernandez M, et al. Modulation of the hyperdynamic circulation of cirrhosis rats by nitric oxide inhibition 〔Ｊ〕. Gastroenterology, 1992; 103(2)∶1909.
19.	Pilette C, Kirstetter P, Sogni P, et al. Dosedependent of a nitric oxide biosynthesis inhibitor on hyperdynamic circulation in two models of portal hypertension in conscious rats 〔Ｊ〕. J Gastroenterol Hepatol, 1996; 11(1)∶1.

1. LopezTalavera JC, Cadelina G, Olchowski J, et al. Thalidomide inhibits tumor necrosis factor, decreases nitric oxide synthesis, and ameliorate the hyperdynamic circulatory syndrome in portalhypertensive rats 〔Ｊ〕. Hepatology, 1996; 23(6)∶1616.
2. Stark ME, Szurszewski JH. Role of nitric oxide in gastrointestenal and hepatic function and disease 〔Ｊ〕. Gastroenterology, 1992; 103(6)∶1928.
3. Colombato LA, Albillos A, Groszmann RJ. Temporal relationship of peripheral vasodilation, plasma volume expansion and the hyperdynamic circulatory state in portalhypertensive rats 〔Ｊ〕. Hepatology, 1992; 15(2)∶323.
4. Albillos A, Colombato LA, Groszmann RJ. Vasodilatation and sodium retention in perhepatic protal hypertension 〔Ｊ〕. Gastroenterology, 1992; 102(3)∶931.
5. Suffredini AF, Fromm RF, Parker MM, et al. The cardivascular response of normal humans to the administration of endotoxin 〔Ｊ〕. N Engl J Med, 1989; 321(5)∶280.
6. Lumsden AB, Henderson M, Kutner MH. Endtoxin levels measured by a chromogenic assay in portal hepatic and peripheral venous blood in patients with cirrhosis 〔Ｊ〕. Hepatology, 1988; 8(2)∶2327Bigatello LM, Broitman SA, Fattori L, et al. Endotoxemia, encephalopathy, and mortality in cirrhotic patients 〔Ｊ〕. Am J Gastroenterol, 1987; 82(1)∶11.
7. Mehta R, Gottstein J, Zeller WP, et al. Endotoxin and hyperdynamic circulation of partal veinligated rats 〔Ｊ〕. Hepatology, 1990; 12(5)∶1152.
8. Nishida T, Huang TP, Seiyama A, et al. Endothelin Areceptor blockade worsens endotoxininduced hepatic microcirculatory changes and necrosis 〔Ｊ〕. Gastroenterology, 1998; 115(2)∶412.
9. Deviere J, Content J, Denys C, et al. Excessive in vitro bacterial lipopolysaccharideinduced production of monokines in cirrhosis 〔Ｊ〕. Hepatology, 1990; 11(4)∶628.
10. Nawroth PP, Bank I, Handley D, et al. Tumor necrosis factor/cachectin interacts with endothelial cell receptor to induce release of interleukin1 〔Ｊ〕. J Exp Med, 1986; 163(6)∶1363.
11. LopezTalavera JC, Merrill WW, Groszmann RJ. Tumor necrosis factor: a major contributor to the hyperdynamic circulation in prehepatic protalhypertensive rats 〔Ｊ〕. Gastroenterology, 1995; 108(3)∶761.
12. Kaneda K, Ekataksin W, Sogawa M, et al. Endothelin1 induced vasoconstriction cause a significant increase in portal pressure of rat liver: localized constrictive effect on the distal segment of preterminal portal venules as revealed by light and electron microscopy and reconstruction 〔Ｊ〕. Hepatology, 1998; 27(3)∶735.
13. Hartleb M, Moreau K, Cailmail S, et al. Vascular hyporesponsiveness to endothelin1 in rats with cirrhosis 〔Ｊ〕. Gastroenterology, 1994; 107(4)∶1085.
14. Ohlstein EH, Elliott JD, Feuerotein GZ, et al. Endothelin receptors: receptor classification, novel receptor antagonists, and potential therapeutic targets 〔Ｊ〕. Med Res Rev, 1996; 16(2)∶365.
15. Cahill PA, MingChin Hou, Hendrickson R, et al. Increased expression of endothelin receptor in the vasculature of portal hypertensive rats: role in splanchnic hemodynamics 〔Ｊ〕. Hepatology, 1998; 28(2)∶396.
16. Gandhi CK, Sproat LA, Subbotin VM. Increased hepatic endothelin1 levels and endothelin receptor density in cirrhotic rats 〔Ｊ〕. Life Sci,1996;58(1)∶55.
17. Rockey NC, Chung JJ. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver, endothelial dysfunction in portal hypertension 〔Ｊ〕. Gastroenterology, 1998; 114(2)∶344.
18. Pizcuta P, Pique JM, Fernandez M, et al. Modulation of the hyperdynamic circulation of cirrhosis rats by nitric oxide inhibition 〔Ｊ〕. Gastroenterology, 1992; 103(2)∶1909.
19. Pilette C, Kirstetter P, Sogni P, et al. Dosedependent of a nitric oxide biosynthesis inhibitor on hyperdynamic circulation in two models of portal hypertension in conscious rats 〔Ｊ〕. J Gastroenterol Hepatol, 1996; 11(1)∶1.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

RESENT STUDY OF PATHOGENESIS IN PORTAL HYPERTENSION

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