QIAO Sen 1 , CHEN Xiaoping. 2
  • Department of General Surgery, Jining The First People’s Hospital of Shangdong Province, Jining 272110;
Primary hepatic carcinoma Interleukin-12 T lymphocyte subset
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Objective  To explore the changes and interrelationship of serum interleukin-12 (IL-12) and T lymphocyte subset in patients with primary hepatic carcinoma (PHC).
Methods  Serum IL-12 level was determined by ELISA in 36 patients with PHC. The peripheral blood T lymphocyte subset was assessed with flow cytometry. The distribution and changes of T lymphocyte subset in the tumor tissue were detected by immunohistochemistry analysis.
Results  The numbers of the CD＋4 T cell were reduced and of the CD＋8 T cell increased either in peripheral blood or tumor tissue, and showed the trend of the ratio (T4/T8) declined progressively with the aggravation of the state with PHC. IL-12 and T4/T8 had significant interrelationship.
Conclusion  IL-12 is an important antitumor factor of the patients with PHC. T lymphocyte subset plays a great role in the process of antitumor.

Citation： QIAO Sen,CHEN Xiaoping.. STUDY ON THE CHANGES AND INTERRELATIONSHIP OF SERUM IL-12 AND T LYMPHOCYTE SUBSET IN PATIENTS WITH PRIMARY HEPATIC CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(5): 302-304. doi: Copy