Objective To determine whether regional arterial infusion (RAI) of 5-Fu and imipenem could decrease infection and mortality of acute necrotic pancreatitis (ANP) or not.
Methods Fifty three patients with ANP were devided into three groups, group A, 16 patients who received intravenous 5-Fu and imipenem, group B, 22 patients who received 5-Fu by RAI and imipenem intravenously, and group C, 15 patients who received both 5-Fu and imipenem by RAI.
Results The incidence of infection of ANP in group C (0%) was significantly lower than that in group A (50.0%) and B (27.2%), and the mortality rates in group B (18.1%) and C (13.3%) were significantly reduced as compared with group C (43.8%).
Conclusion RAI of 5-Fu and imipenem was effective in reducing ANP infection and mortality rates.
Citation:
SUN Libo,ZHANG Deheng,TIAN Li,et al.. REGIONAL ARTERIAL INFUSION OF 5-Fu AND IMIPENEM DECREASES INFECTION AND MORTALITY OF ACUTE SEVERE PANCREATITIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(6): 373-374. doi:
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顾风元, 陆永良, 潘人伟等. 区域性动脉灌注5Fu治疗急性坏死性胰腺炎 〔J〕. 中华外科杂志, 1995; 33(6)∶339.
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武田和惠, 小针亚男,砂村真琴, 他. 重症急性月萃炎の新しい治疗 〔J〕. 最新医学, 1992; 47(10)∶2168.
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Sainiao V, Kempaineu E, Pvolakkainen P, et al. Early antibiotic treatment in acute necrotizing pancreatitis 〔J〕. Lancet, 1995; 346(18)∶634.
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孙家帮, 朱彬, 贾建国等. 抗菌药物对预防重症急性胰腺炎感染的作用 〔J〕. 中华普通外科杂志, 1997; 12(4)∶214.
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Johnson CD. Antibiotic prophylaxis in severe acute pancreatitis 〔J〕. Br J Surg, 1996; 83(7)∶883.
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Barie PS. A critical review of antibiotic prophylaxis in severe acute pancreatitis 〔J〕. Am J Surg, 1996; 172(12)∶38S.
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- 1. 顾风元, 陆永良, 潘人伟等. 区域性动脉灌注5Fu治疗急性坏死性胰腺炎 〔J〕. 中华外科杂志, 1995; 33(6)∶339.
- 2. 武田和惠, 小针亚男,砂村真琴, 他. 重症急性月萃炎の新しい治疗 〔J〕. 最新医学, 1992; 47(10)∶2168.
- 3. Sainiao V, Kempaineu E, Pvolakkainen P, et al. Early antibiotic treatment in acute necrotizing pancreatitis 〔J〕. Lancet, 1995; 346(18)∶634.
- 4. 孙家帮, 朱彬, 贾建国等. 抗菌药物对预防重症急性胰腺炎感染的作用 〔J〕. 中华普通外科杂志, 1997; 12(4)∶214.
- 5. Johnson CD. Antibiotic prophylaxis in severe acute pancreatitis 〔J〕. Br J Surg, 1996; 83(7)∶883.
- 6. Barie PS. A critical review of antibiotic prophylaxis in severe acute pancreatitis 〔J〕. Am J Surg, 1996; 172(12)∶38S.