EFFECT OF TOTAL PARENTERAL NUTRITION PLUS RECOMBINANT GROWTH HOMONE ON THE NUTRITIONAL STATUS OF PATIENTS FOLLOWING MAJOR ABDOMINAL SURGERY_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Li , RAN Jianghua , ZHANG Binyan , et al.

Department of Hepatobiliary Surgery, The Second Affiliated Hospital, Kunming Medical College, Kunming 650101;

Corresponding author：

Keywords：

Recombinant growth hormone Total parenteral nutrition Major abdominal surgery Nitrogen balance

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Abstract Full text Figures/Tables Video References Cited by

Objective To research the effects of recombinant growth hormone (rhGH) with total parenteral nutrition (TPN) on nitrogen balance and nutritional state of the patients following major abdominal surgery.
Methods We randomly selected 45 patients receiving TPN after major abdominal surgery and distributed them to study group (rhGH+TPN, n＝30) and control group (TPN only, n＝15). For 7 days after operation, every one was given rhGH 4u or replaced by hypodermic injection of normal saline (control group).
Results TPN+rhGH promoted the rehabilitant of nitrogen balance, heightened the level of plasma albumin and transferrin and increased the weight and creatinin/height index (CHI), but the thickness of triceps skin fold (TSF) had no significant change in patients following major abdominal surgery.
Conclusion The rhGH can improve the effects of TPN.

Citation： LI Li,RAN Jianghua,ZHANG Binyan,et al.. EFFECT OF TOTAL PARENTERAL NUTRITION PLUS RECOMBINANT GROWTH HOMONE ON THE NUTRITIONAL STATUS OF PATIENTS FOLLOWING MAJOR ABDOMINAL SURGERY. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(6): 383-385. doi: Copy

1.	VaraThorbeck R, Guerrero JA, Rosell J, et al. Exogenous growth hormone: effects on the catabolic response to surgically reduced acute stress and on postoperative immune function 〔Ｊ〕. World J Surg, 1993; 17(4)∶530.
2.	Petersson B, Wemerman J, Waller SO, et al. Elective abdominal surgery depresses muscles protein synthesis and increases subjective fatigue: effects lasting more than 30 days 〔Ｊ〕. Br J Surg, 1990; 77(7)∶796.
3.	Ross RJ, Chew SL. Acquired growth hormone resistance 〔Ｊ〕. Eur J Endocrinol, 1995; 132(6)∶655.
4.	Wong WK, Cascarelli A, Rice HE, et al. The effect of recombinant growth hormone on nitrogene balance in malnoruished patients after major abdominal surgery aust 〔Ｊ〕. NZ J Surg, 1995; 65(6)∶109.
5.	Hammarqvist F, Leong M, Titik C, et al. Biosynthetic human growth hormone preserves both muscle protein synthesis and the decrease in musclefree grutamine, and improves wholebody nitrogen economy after operation 〔Ｊ〕. Ann Surg, 1992; 216(2)∶184.
6.	严律南，曾勇，文天夫等. 重组人生长激素对肝叶切除术后肝脏再生作用的研究〔Ｊ〕. 中国实用外科杂志， 1999； 19(Suppl)∶46.
7.	VaraThorbeck R, Diehl AK, Mirza DF, et al. The effects of human growth hormone on postoperative catabolic state 〔Ｊ〕. Horm Res, 1996; 45(1)∶55.

1. VaraThorbeck R, Guerrero JA, Rosell J, et al. Exogenous growth hormone: effects on the catabolic response to surgically reduced acute stress and on postoperative immune function 〔Ｊ〕. World J Surg, 1993; 17(4)∶530.
2. Petersson B, Wemerman J, Waller SO, et al. Elective abdominal surgery depresses muscles protein synthesis and increases subjective fatigue: effects lasting more than 30 days 〔Ｊ〕. Br J Surg, 1990; 77(7)∶796.
3. Ross RJ, Chew SL. Acquired growth hormone resistance 〔Ｊ〕. Eur J Endocrinol, 1995; 132(6)∶655.
4. Wong WK, Cascarelli A, Rice HE, et al. The effect of recombinant growth hormone on nitrogene balance in malnoruished patients after major abdominal surgery aust 〔Ｊ〕. NZ J Surg, 1995; 65(6)∶109.
5. Hammarqvist F, Leong M, Titik C, et al. Biosynthetic human growth hormone preserves both muscle protein synthesis and the decrease in musclefree grutamine, and improves wholebody nitrogen economy after operation 〔Ｊ〕. Ann Surg, 1992; 216(2)∶184.
6. 严律南，曾勇，文天夫等. 重组人生长激素对肝叶切除术后肝脏再生作用的研究〔Ｊ〕. 中国实用外科杂志， 1999； 19(Suppl)∶46.
7. VaraThorbeck R, Diehl AK, Mirza DF, et al. The effects of human growth hormone on postoperative catabolic state 〔Ｊ〕. Horm Res, 1996; 45(1)∶55.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EFFECT OF TOTAL PARENTERAL NUTRITION PLUS RECOMBINANT GROWTH HOMONE ON THE NUTRITIONAL STATUS OF PATIENTS FOLLOWING MAJOR ABDOMINAL SURGERY

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