• Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital, Sun YatSen University of Medical Sciences, Guangzhou 510080;
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Objective  To study the advances in microcirculation after islets of Langerhans transplantation (ILT).
Methods  The literature in the recent years on the study of the relationship between ILT and microcirculation was reviewed.
Results  The process of angiogenesis and revascularization of the islet grafts was in progress within 1 week after transplantation, and was completed within 10-14 days after transplantation, exhibiting a microangioarchitecture similar to pancreatic islets in situ. The sequence of vascular intraislet cellular perfusion was from β cells outward to α-and δ-cell cortex, with the majority of α cells perfused before the majority of δ cells. Freely transplanted islet grafts were revascularized from the hostderived microvascular bed. The interstitial pressure in the islet transplants was markedly lower than the capillary pressure. There were clearly differences in microcirculation between syngeneic and xenogeneic islet grafts. The phenomena of microcirculation failure were observed in xenografts. The influential factors of microcirculation after ILT were ①culture temperature of isolated islets, ②cultured time and cryopreserved method of islets, ③blood glucose, ④immunosuppressive agents, ⑤angiogenesis factors.
Conclusion  Microvascularization of freely islet grafts is one of the essential requirements for successful engraftment, guaranteeing sufficient nutritional blood supply to the tissue and establishing blood drainage for adequate liberation of the endocrine hormones. Through the studies of the microcirculation after ILT, it is helpful to recognize the mechanism of the survival of islet grafts.

Citation: CHEN Chuangqi,LAN Ping,ZHAN Wenhua.. STUDIES OF THE RELATIONSHIP BETWEEN ISLETS OF LANGERHANS TRANSPLANTATION AND MICROCIRCULATION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(6): 411-414. doi: Copy