REN Weiying , ZHU Lei , ZHAO Rongya , ZHU Wenjing , SHEN Qinjun , LI Li , CHEN Qi , YANG Yanjie
  • Department of Respiratory Medicine, Zhongshan Hospital, Fudan University. Shanghai, 200032, China Corresponding Author: ZHULei, E-mail: tfzhu@ 126. com;
Pulmonary function parameters; Medical reference; Forced expiratory volume in the first second; Lower limits of normal
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Objective  To establish amedical reference for adult pulmonary function parameters and a normal FEV1 /FVC% pred in population of Shanghai.
Methods  Subjects who underwent routine physical examination were initially screened and those who met enrollment criteria with age over 18 years old were required to underwent pulmonary function tests in Zhongshan Hospital from June 2009 to February 2010. After screening of 450 subjects, a total of 240 subjects with normal pulmonary function and 120 subjects with mild small airway abnormalities were enrolled in this study according to the prediction equations established in1988. All subjects were assigned into 6 groups according to their age with30 males amd 30 females in each group. Pulmonary function parameters including VC, FVC, FEV1 , FEV1 /FVC, PEF, FEF25% , FEF50% , FEF75% , RV, FRC, TLC, RV /TLC, DLCO, and KCO were collected for analysis. New prediction equations for the above 14 parameters were established by parameters of anthropometry. The medical reference ranges of 14 parameters were calculated according to the newprediction equations. The normal FEV1 /FVC%pred was also calculated.
Results  New prediction equations for normal adult pulmonary function parameters in Shanghai were established. DLCO =5.206 +4. 314 ×gender ( “male”= 1, “female”=0) - 0. 144 ×age( y) +0. 098 × height( cm) +0. 082 ×weight( kg) , KCO =9. 346 - 0. 026 ×age( y) - 0. 031 ×height( cm) +0. 025 ×weight( kg) .The LLN( P5) of VC, FVC, FEV1 , FEV1 /FVC, the LLN( P2. 5 ) and the upper limit of normal value ( P97. 5) of FRC, TLC, RV, RV/TLC were calculated. The LLN( P5) of FEV1 /FVC = 101. 924 - 0. 144 × age ( y) - 0. 118 ×high( cm) . The lower normal limit of FEV1 /FVC% pred was 92% .
Conclusions  This is the first time to have the medical reference of FEV1 /FVC% pred in China, and new prediction equations for DLCO in Shanghai. The LLN of FEV1 /FVC or FEV1 /FVC% pred  lt;92% can be used as diagnostic criteria for obstructive ventilation disorder. Instead of using FEV1% pred  lt; 80% , FEV1  lt; LLN can be used as diagnostic criteria for mild ventilation disorder.

Citation： REN Weiying,ZHU Lei,ZHAO Rongya,ZHU Wenjing,SHEN Qinjun,LI Li,CHEN Qi,YANG Yanjie. Preliminary Study on Medical Reference Range for Adult Pulmonary Function Parameters in Shanghai. Chinese Journal of Respiratory and Critical Care Medicine, 2012, 11(3): 253-256. doi: Copy