Prethrombotic state of chronic obstructive pulmonary disease patients with ventilator associated pneumonia and the efect of anticoagulation therapy_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 YAN Feng , LUO Wenling , WANG Ruiqin , CUI Rong

Department of Respiratory Medicine，The First Affliated Hospital Tsinghua University．Beijing，100016，China Corresponding author：YAN Feng，E-mail：yanfengyixue@163．com;

Corresponding author：

YAN Feng, Email: yanfengyixue@163.com

Keywords：

Chronic obstructive pulmonary disease; Ventilator—associated pneumonia; Antieoagulation

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the prethrombotic state and effect of anticoagulation therapy in patients with chronic obstructive pulmonary disease(COPD) and ventilator-associated pneumonia (VAP)．Methods Forty-six COPD patients were divided into VAP group(25 cases)and non-VAP group (21 cases)．The VAP group were randomly subdivided into two groups：group A(conventional therapy group，n=13)，group B(conventional therapy+anticoagulation therapy group，n=12)．The D-dimer (DD)，fibfinogen(FIB)，pulmonary artery pressure(PAP)and the time of weaning were compared between these groups．Results In the COPD patients，the levels of DD，FIB and PAP were significantly increased in VAP group compared with non-VAP group[(0．50±0．26)mg／L，(3．67 ±0．88) L，(31．71 ± 5．66)mm Hg vs(0．23±0．12)mg／L，(1．56±0．45) L，(15．28 ±2．84)mm Hg，respectively，all P lt; 0．05]．In the COPD patients with VAP，the levels of DD，the content of FIB，PAP and mortality were significantly lower in group B with shorter time of weaning compared with group A[(0．22±0．16)mg／L， (1．56±1．17)g／L，(16．00±2．48)him Hg，8．33％ and(4．00±1．41)d vs(O／41±0．09)mg／L，(3．66± 1．03) L，(28．00±0．85)mm Hg，15．4％ and(10．76±3．35)d，respectively，all P lt;0．05]． Conclusions Prethrombotic state exists in COPD patients with VAP．Aggressive anticoagulation on base of routine therapy，by ameliorating microcireulation，call shorten the time of weaning and reduce the mortalit in these patient

Citation： YAN Feng,LUO Wenling,WANG Ruiqin,CUI Rong. Prethrombotic state of chronic obstructive pulmonary disease patients with ventilator associated pneumonia and the efect of anticoagulation therapy. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(6): 424-426. doi: Copy

1.	Safdar N，Crnich CJ，Maki DG．The pathogenesis of ventilatorassociated pneumonia：its l~levance to developing effective strategies for prevention．Respir Care，2005，50：725-739.
2.	1 Romano PM ，Peterson S．The management of cor pulmonale．Heart Dis，2000，2：431-437．.
3.	杨冠华，王煜，胡雪君，等．30例呼吸机相关肺炎病原学与临床分析．中国呼吸与危重监护杂志，2004，3：317。 3 李华茵，何礼贤，胡必杰，等．重症监护病房呼吸机相关肺炎临床与病原学分析．中国呼吸与危重监护杂志，2005，4：266-270.
4.	Markowiez P，Wolff M，Djedaini K，et al．Multicenter prospective study of ventilator—associated pneumonia during acute respiratory dis tress syndrome：incidence，prognosis，and risk factors．ARDS Study Group．Am J Respir Crit Care Med，2000，161：1942-1948.
5.	Weinherge B，Carbone T，England S，et al．Effect of perinateal hypoxiaon senlm unbind free fatty acids and lung inflammatory mediators. Biol Neonate，2001，79：61-66.
6.	赵建华，冯孟森，王倩，等．抗凝治疗肺心病血栓前状态的临床研究．中国医师杂志，2004，6：1622-1623.
7.	王丽杰，孙正琦，宋颖．肺源性心脏病血栓前状态及奥扎格雷抗凝疗效分析．中国医药，2006，1：82-83.
8.	Sin DD．Man SF. 西 are ratientswith chronic obstructive pulmonary disease at increased risk of cardiovasculm"diseases?the potential role of systemic inflammation in chronic obstructive pulmorary disease．Circulation，2003，107：1514-1519. 9 郭欣然，翁玉清，谢灿茂．肺心病血栓前状态及抗凝干预疗效分析．中国实用内科学杂志，2002，22：479-480.
9.	Wedzicha JA．The heterogeneity of chronic obstructive pulmonary diseae．Thorax，2000，55：631-632.

1. Safdar N，Crnich CJ，Maki DG．The pathogenesis of ventilatorassociated pneumonia：its l~levance to developing effective strategies for prevention．Respir Care，2005，50：725-739.
2. 1 Romano PM ，Peterson S．The management of cor pulmonale．Heart Dis，2000，2：431-437．.
3. 杨冠华，王煜，胡雪君，等．30例呼吸机相关肺炎病原学与临床分析．中国呼吸与危重监护杂志，2004，3：317。 3 李华茵，何礼贤，胡必杰，等．重症监护病房呼吸机相关肺炎临床与病原学分析．中国呼吸与危重监护杂志，2005，4：266-270.
4. Markowiez P，Wolff M，Djedaini K，et al．Multicenter prospective study of ventilator—associated pneumonia during acute respiratory dis tress syndrome：incidence，prognosis，and risk factors．ARDS Study Group．Am J Respir Crit Care Med，2000，161：1942-1948.
5. Weinherge B，Carbone T，England S，et al．Effect of perinateal hypoxiaon senlm unbind free fatty acids and lung inflammatory mediators. Biol Neonate，2001，79：61-66.
6. 赵建华，冯孟森，王倩，等．抗凝治疗肺心病血栓前状态的临床研究．中国医师杂志，2004，6：1622-1623.
7. 王丽杰，孙正琦，宋颖．肺源性心脏病血栓前状态及奥扎格雷抗凝疗效分析．中国医药，2006，1：82-83.
8. Sin DD．Man SF. 西 are ratientswith chronic obstructive pulmonary disease at increased risk of cardiovasculm"diseases?the potential role of systemic inflammation in chronic obstructive pulmorary disease．Circulation，2003，107：1514-1519. 9 郭欣然，翁玉清，谢灿茂．肺心病血栓前状态及抗凝干预疗效分析．中国实用内科学杂志，2002，22：479-480.
9. Wedzicha JA．The heterogeneity of chronic obstructive pulmonary diseae．Thorax，2000，55：631-632.

Chinese Journal of Respiratory and Critical Care Medicine

Prethrombotic state of chronic obstructive pulmonary disease patients with ventilator associated pneumonia and the efect of anticoagulation therapy

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content