Forced expiratory volume in six seconds in the spirometric diagnosis of airway obstruction_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 JIANG Lei , WANG Hong , YIN Kaisheng , HUANG Mao , SUN Peili , FENG Yua

Department of Respiratory Medicine，The Frist Afiliated Hospital of nanjing Medical University．Nanjing，Jiangsu，210029，ChinaCorresponding author：JIANG Lei ，E-mail：leifuj@yahoo.com.cn;

Corresponding author：

JIANG Lei , Email: leifuj@yahoo.com.cn

Keywords：

Forced expiratory volume in six seconds; Airway obstruction; Diagnosis; Pulmonary function testing; Spirometr

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0bjective To evaluate the efficacy of FEV6 and FEV1／FEV6 as surrogates for FVC and FEV1／FVC in the spirometric diagnosis of airway obstruction，and to determine the fixed cut-off point of FEV1／FEV6 which can be used as an alternative for FEV1／FVC lt; 70％.Methods Spirometry measurements were perform ed in 128 participants．FEV1，FEV6，FVC，FEV1％pred，FVC％pred，FEV1／FVC and FEV1／FEV6 were measured and analyzed.FEV1／FVC lt;70％ was used as the“gold standard”。Severity of obstruction was based on FEV ％ pred．From ROC curve analysis，the FEV1／FEV6 ratio，which corresponded to optimal combination of sensitivity and specificity，was determined．Correlation between FEV1／FVC and FEV1／FEV6 was studied．Results Of 128 participants，there were 65(51％)with FEV1／FVC ≥70％．Of the 63 participants with FEV1／FVC lt;70％，there were 5 with FEV1／FEV6 between 70.09％ to 71％。There was no significant difference between the mean value of FVC and that of FEV ．Lifear correlation was revealed between FEV1／FVC and FEV1／FEV6 with the value close to 1(r=0.9979，P lt;0.0001)．From ROC curve analysis，the FEV1／FEV6 lt;71.14％ was the best cut-off point coresponding to FEV1／FVC lt;70％．Conclusion These results suggest that FEV1／FEV6 is a valid alternative to FEV1／FVC for spirometric diagnosis of airw ay obstruction．There is a b corelation between FEV1／FEV6 and FEV1／FVC．

Citation： JIANG Lei ,WANG Hong,YIN Kaisheng,HUANG Mao,SUN Peili,FENG Yua. Forced expiratory volume in six seconds in the spirometric diagnosis of airway obstruction. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(6): 452-454. doi: Copy

1.	GOLD Executive Committ．Guidelines：Global Strategy for Diagnosis，Management，and Prevention of COPD．Updated 2007．http：／／www／ goldcopd．com／guidelineitem.
2.	Miller MR，Hankinson J，Brusasco V，et al．ATS／ERS Task Force： Standardisation of spirometry．Eur Respir J，2005，26：319—338.
3.	Akpinar-Elci M，Fedan KB，Enright PL．FEV6 as a surrogate for FVC in detecting airway obstruction and restriction in the workplace．Eur Respir J，2006，27：374-377.
4.	Pedersen OF．FEV6：a shortcut in spirometry?Eur Respir J，2006， 27：245-247.
5.	Hankinson JL，Odencrantz JR，Fedan KB．Spirometric reference values from a sample of the general U.S．population．Am J Respir Crit Care Med，1999，159：179-187.
6.	Swanney MP，Jensen RL，Criehton DA，et al．FEV6 is an acceptable surrogate for FVC in the spirometric diagnosis of airway obstruction and restriction．Am J Respir Crit Care Med，2000，162：917-919.
7.	Lundgren FL，Cabral MM，Climaco DC，et al．Determination of the eficacy of FEV6 as a surogate for FVC in the diagnostic screening for chronic obstructive pulmonary disease through the comparison of FEV1／FVC and FEV1／FEV6 ratios．J Bras Pneumol，2007，33：148-151.
8.	Rosa FW ，Perez-Padilla R，Camelier A，et al．Efficacy of the FEV1／ FEV6 ratio compared to the FEV1／FVC ratio for the diagnosis of airway obstruction in subjects aged 40 years or over,Braz J Med Biol Res，2007，40：1615-1621.
9.	Vandevoorde J，Verbanck S，Schuermans D，et al．Obstructive and restrictive spirometric patterns：fixed cut—oil’s for FEV1／FEV6 and FEV6．Eur Respir J，2006，27：378-383．.

1. GOLD Executive Committ．Guidelines：Global Strategy for Diagnosis，Management，and Prevention of COPD．Updated 2007．http：／／www／ goldcopd．com／guidelineitem.
2. Miller MR，Hankinson J，Brusasco V，et al．ATS／ERS Task Force： Standardisation of spirometry．Eur Respir J，2005，26：319—338.
3. Akpinar-Elci M，Fedan KB，Enright PL．FEV6 as a surrogate for FVC in detecting airway obstruction and restriction in the workplace．Eur Respir J，2006，27：374-377.
4. Pedersen OF．FEV6：a shortcut in spirometry?Eur Respir J，2006， 27：245-247.
5. Hankinson JL，Odencrantz JR，Fedan KB．Spirometric reference values from a sample of the general U.S．population．Am J Respir Crit Care Med，1999，159：179-187.
6. Swanney MP，Jensen RL，Criehton DA，et al．FEV6 is an acceptable surrogate for FVC in the spirometric diagnosis of airway obstruction and restriction．Am J Respir Crit Care Med，2000，162：917-919.
7. Lundgren FL，Cabral MM，Climaco DC，et al．Determination of the eficacy of FEV6 as a surogate for FVC in the diagnostic screening for chronic obstructive pulmonary disease through the comparison of FEV1／FVC and FEV1／FEV6 ratios．J Bras Pneumol，2007，33：148-151.
8. Rosa FW ，Perez-Padilla R，Camelier A，et al．Efficacy of the FEV1／ FEV6 ratio compared to the FEV1／FVC ratio for the diagnosis of airway obstruction in subjects aged 40 years or over,Braz J Med Biol Res，2007，40：1615-1621.
9. Vandevoorde J，Verbanck S，Schuermans D，et al．Obstructive and restrictive spirometric patterns：fixed cut—oil’s for FEV1／FEV6 and FEV6．Eur Respir J，2006，27：378-383．.

Chinese Journal of Respiratory and Critical Care Medicine

Forced expiratory volume in six seconds in the spirometric diagnosis of airway obstruction

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