YANG Shengping 1,2 , LI Jingyuan 1,3 , YAN Xianxia 1,2 , YANG Kehu 1,2 , LIU Yali 1
  • 1. Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China;2. The First Clinical Medicine College of Lanzhou University, Lanzhou 730000, China;3. Pingliang People’s Hospital, Pingliang 744000, China;
LIU Yali, Email: lyl2010_06@126.com
Meningococcal vaccine; Adverse events following immunization; Safety evaluation
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Objective　 To evaluate the adverse events following immunization (AEFI) of meningococcal vaccines, so as to provide references for the appraisal and treatment of AEFI.
Methods　 The Chinese Bio-medicine Database (1978 to April, 2010), China Journal Full-text Database (1994 to April, 2010), VIP Database (1989 to April, 2010) and WangFang database (1988 to April, 2010) were fully searched, and the references listed in original studies were searched manually as well. Then two reviewers independently screened studies and abstracted relevant data.
Results　 A total of 52 articles involving 61 cases were included. Among the AEFI cases, 72.13% were hypersensitive response, including henoch-schonlein purpura (accompanied with or without nephritis), anaphylactic shock, allergic eruption, angioedema, local allergic reaction and so on.
Conclusion　 The results of this study show that meningococcal vaccines may result in AEFI. However, most AEFI are temporary and can be cured after treatment in time. In general, meningococcal vaccine is safe, but monitoring and treatment for AEFI are necessary.

Citation： YANG Shengping,LI Jingyuan,YAN Xianxia,YANG Kehu,LIU Yali. A Review on Adverse Events Following Immunization of Meningococcal Vaccines. Chinese Journal of Evidence-Based Medicine, 2011, 11(12): 1468-1470. doi: Copy

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