In the absence of large trials, it is important for us to discuss whether a well-conducted meta-analysis of smaller randomized controlled trial (RCT) can replace large trials or not. We have evaluated the quality of original literature and methodological quality. The difference between meta-analysis of smaller RCT and the largest randomized trials have also discussed.
Citation： WEI Qiang,PENG Guohui. Large trials vs meta analysis of smaller trials. Chinese Journal of Evidence-Based Medicine, 2002, 02(2): 104-107. doi: Copy