Objective To assess the effectiveness of adjuvant chemotherapy with complete resection for non-small cell lung cancer.
Methods We searched MEDLINE (1966 ~ 2005 ), EMBASE (1984-2005 ), The Cochrane Library (Issue 2,2005 ), CBMdisc (1979-2005 ), CNKI (1994-2005 ), VIP (1989-2005 ), CMCC (1994-2005 ) and Wanfang Database with key words of non-small cell lung cancer or NSCLC and adjuvant chemotherapy, to identify randomized control trials (RCTs) of platinum-based adjuvant chemotherapy plus complete resection versus complete resection alone for non-small cell lung cancer patients. Two reviewers evaluated the quality of literature independently. Then we conducted meta-analysis using RevMan 4.2.7 software.
Results We identified 9 RCTs and did not carry out pool analysis for the difference of chemotherapy regimens between the studies. The results of three studies showed that 5 years' mortality of adjuvant chemotherapy group was lower than that of surgery group alone. The results of the other 6 studies showed there was no statistical difference in 5 years' mortality between the adjuvant chemotherapy plus surgery and surgery alone groups.
Conclusions The effectiveness of some adjuvant chemotherapy regimens with complete resection in patients with non-small cell lung cancer has been improved. But the number of each chemotherapy regimen RCT is too small and with poor quality. So more multi-center RCTs with a larger sample size and high quality are needed.
Citation: XIA Jia ,LI Xiaosong. Effectiveness of Adjuvant Chemotherapy with Complete Resection for Non-small Cell Lung Cancer. Chinese Journal of Evidence-Based Medicine, 2005, 05(12): 936-940. doi: Copy