CD4+ T细胞介导的免疫反应在面神经损伤修复中的作用_West China Medical Journal

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宋俊 ¹ , 龚树生 ²

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Keywords：

面神经损伤; 免疫反应; 修复

DOI：

CNKI: 51-1356/R.20120115.1555.040

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随着神经免疫学的发展，越来越多的研究表明免疫系统和神经系统之间存在着相互作用，最近研究也发现，CD4+T细胞介导的获得性免疫反应对面神经损伤后的面运动神经元活性的维持起着重要作用，其具体细胞亚群是由相关信号传导子及转录激活子介导的从CD4+T细胞分化来的Th2亚群。此类研究有助于指导相关临床工作。

Citation： 宋俊,龚树生. CD4+ T细胞介导的免疫反应在面神经损伤修复中的作用. West China Medical Journal, 2012, 27(1): 145-147. doi: CNKI: 51-1356/R.20120115.1555.040 Copy

1.	Marcondes MC, Furtado GC, Wensky A, et al. Immune regulatory mechanisms influence early pathology in spinal cord injury and in spontaneous autoimmune encephalomyelitis[J]. Am J Pathol, 2005, 166(6): 1749–1760.
2.	Serpe CJ, Kohm AP, Huppenbauer CB, et al. Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice[J]. J Neurosci, 1999, 19(11): 7.
3.	Serpe CJ, Sanders VM, Jones KJ. Kinetics of facial motoneuron loss following facial nerve transection in severe combined immunodeficient mice[J]. J Neurosci Res, 2000, 62(2)：273-278.
4.	Besser M, Wank R. Cutting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th3-polarized expression of their receptors[J]. J Immunol, 1999, 163(11): 6303-6306.
5.	Serpe CJ, Byram SC, Sanders VM, et al. Brain-derived neurotrophic factor supports facial motoneuron survival after facial nerve transection in immunodeficient mice[J]. Brain Behav Immun, 2005, 19(2): 173-180.
6.	Jones KJ, Serpe CJ, Byram, SC, et al. Role of the immune system in the maintenance of mouse facial motoneuron viability after nerve injury[J]. Brain Behav Immun, 2005, 19(1): 12-19.
7.	Marzo SJ, Moeller CW, Sharma N, et al. Facial motor nuclei cell loss with intratemporal facial nerve crush injuries in rats[J]. Laryngoscope, 2010, 120(11): 2264-2269.
8.	Canh MY, Serpe CJ, Sanders V, Jones KJ. CD4+ T cell-mediated facial motoneuron survival after injury: Distribution pattern of cell death and rescue throughout the extent of the facial motor nucleus[J]. J Neuroimmune, 2006, 181(1-2): 93-99.
9.	Mesnard NA, Alexander TD, Sanders VM, et al. Use of laser microdissection in the investigation of facial motoneuron and neuropil molecular phenotypes after peripheral axotomy[J]. Exp Neurol, 2010, 225(1): 94-103.
10.	Serpe CJ, Coers S, Sanders VM, et al. CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection[J]. Brain Rehav Immun, 2003, 17(5): 393-402.
11.	Kaplan MH, Schindler U, Smiley ST, et al. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells[J]. Immunity, 1996, 4(3): 313-319.
12.	Deboy CA, Xin J, Byram SC, et al. Immune-mediated neuroprotection of axotomized mouse facial motoneurons is dependent on the IL-4/STATE signaling pathway in CD4+ T cells[J]. Exp Neurol, 2006, 201(1): 212-224.
13.	Xin J, Wainwright DA, Serpe CJ, et al. Phenotype of CD4+ T cell subsets that develop following mouse facial nerve axotomy[J]. Brain Behav Immun, 2008, 22(4): 528-37.
14.	Wainwright DA, Mesnard NA, Xin J, et al. Effects of facial nerve axotomy on Th2-associated and Th1-associated chemokine mRNA expression in the facial motor nucleus of wild-type and presymptomatic SOD1 mice[J]. J Neurodegener Regen, 2009, 2(1): 39-44.
15.	Wainwright DA, Xin J, Mesnard NA, et al. Toll-like receptor 2 and facial motoneuron survival after facial nerve axotomy[J]. Neurosci Lett, 2010, 471(1): 10-14.
16.	Byram SC, Carson MJ, DeBoy CA, et al. CD4+ T cell-mediated neuroprotection requires dual compartment antigen presentation[J]. J Neurosci, 2004, 18(18): 4333-4339.
17.	Aloisi F, Ria F, Adorini L. Regulation of T-cell responses by CNS　antigen-presenting cells: different roles for microglia and astrocytes[J]. Immunol Today, 2000, 21(3): 141-147.
18.	Becher B, Prat A, Antel JP. Brain-immune connection: immuno-regulatory properties of CNS-resident cells[J]. Glia, 2000, 29(4): 293-304.
19.	Zhi Huang, Grace K Ha, John M, et al. IL-15 and IL-15Ra gene deletion: Effects on T lymphocyte trafficking and the microglial and neuronal responses to facial nerve axotomy[J]. Neurosci Lett, 2007, 417(2): 160-164.
20.	Xin J, Wainwright DA, Mesnard NA, et al. IL-10 within the CNS is necessary for CD4(+) T cells to mediate neuroprotection[J]. Brain Behav Immun, 2011, 25(5): 820-829.
21.	Byram SC, Serpe CJ, Pruett SB, et al. Natural killer cells do not mediate facial motoneuron survival after facial nerve transection[J]. Brain Behav Immun, 2003, 17(6): 417-425.

1. 　Marcondes MC, Furtado GC, Wensky A, et al. Immune regulatory mechanisms influence early pathology in spinal cord injury and in spontaneous autoimmune encephalomyelitis[J]. Am J Pathol, 2005, 166(6): 1749–1760.
2. 　Serpe CJ, Kohm AP, Huppenbauer CB, et al. Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice[J]. J Neurosci, 1999, 19(11): 7.
3. 　Serpe CJ, Sanders VM, Jones KJ. Kinetics of facial motoneuron loss following facial nerve transection in severe combined immunodeficient mice[J]. J Neurosci Res, 2000, 62(2)：273-278.
4. 　Besser M, Wank R. Cutting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th3-polarized expression of their receptors[J]. J Immunol, 1999, 163(11): 6303-6306.
5. 　Serpe CJ, Byram SC, Sanders VM, et al. Brain-derived neurotrophic factor supports facial motoneuron survival after facial nerve transection in immunodeficient mice[J]. Brain Behav Immun, 2005, 19(2): 173-180.
6. 　Jones KJ, Serpe CJ, Byram, SC, et al. Role of the immune system in the maintenance of mouse facial motoneuron viability after nerve injury[J]. Brain Behav Immun, 2005, 19(1): 12-19.
7. 　Marzo SJ, Moeller CW, Sharma N, et al. Facial motor nuclei cell loss with intratemporal facial nerve crush injuries in rats[J]. Laryngoscope, 2010, 120(11): 2264-2269.
8. 　Canh MY, Serpe CJ, Sanders V, Jones KJ. CD4+ T cell-mediated facial motoneuron survival after injury: Distribution pattern of cell death and rescue throughout the extent of the facial motor nucleus[J]. J Neuroimmune, 2006, 181(1-2): 93-99.
9. 　Mesnard NA, Alexander TD, Sanders VM, et al. Use of laser microdissection in the investigation of facial motoneuron and neuropil molecular phenotypes after peripheral axotomy[J]. Exp Neurol, 2010, 225(1): 94-103.
10. 　Serpe CJ, Coers S, Sanders VM, et al. CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection[J]. Brain Rehav Immun, 2003, 17(5): 393-402.
11. 　Kaplan MH, Schindler U, Smiley ST, et al. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells[J]. Immunity, 1996, 4(3): 313-319.
12. 　Deboy CA, Xin J, Byram SC, et al. Immune-mediated neuroprotection of axotomized mouse facial motoneurons is dependent on the IL-4/STATE signaling pathway in CD4+ T cells[J]. Exp Neurol, 2006, 201(1): 212-224.
13. 　Xin J, Wainwright DA, Serpe CJ, et al. Phenotype of CD4+ T cell subsets that develop following mouse facial nerve axotomy[J]. Brain Behav Immun, 2008, 22(4): 528-37.
14. 　Wainwright DA, Mesnard NA, Xin J, et al. Effects of facial nerve axotomy on Th2-associated and Th1-associated chemokine mRNA expression in the facial motor nucleus of wild-type and presymptomatic SOD1 mice[J]. J Neurodegener Regen, 2009, 2(1): 39-44.
15. 　Wainwright DA, Xin J, Mesnard NA, et al. Toll-like receptor 2 and facial motoneuron survival after facial nerve axotomy[J]. Neurosci Lett, 2010, 471(1): 10-14.
16. 　Byram SC, Carson MJ, DeBoy CA, et al. CD4+ T cell-mediated neuroprotection requires dual compartment antigen presentation[J]. J Neurosci, 2004, 18(18): 4333-4339.
17. 　Aloisi F, Ria F, Adorini L. Regulation of T-cell responses by CNS　antigen-presenting cells: different roles for microglia and astrocytes[J]. Immunol Today, 2000, 21(3): 141-147.
18. 　Becher B, Prat A, Antel JP. Brain-immune connection: immuno-regulatory properties of CNS-resident cells[J]. Glia, 2000, 29(4): 293-304.
19. 　Zhi Huang, Grace K Ha, John M, et al. IL-15 and IL-15Ra gene deletion: Effects on T lymphocyte trafficking and the microglial and neuronal responses to facial nerve axotomy[J]. Neurosci Lett, 2007, 417(2): 160-164.
20. 　Xin J, Wainwright DA, Mesnard NA, et al. IL-10 within the CNS is necessary for CD4(+) T cells to mediate neuroprotection[J]. Brain Behav Immun, 2011, 25(5): 820-829.
21. 　Byram SC, Serpe CJ, Pruett SB, et al. Natural killer cells do not mediate facial motoneuron survival after facial nerve transection[J]. Brain Behav Immun, 2003, 17(6): 417-425.

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West China Medical Journal

CD4+ T细胞介导的免疫反应在面神经损伤修复中的作用

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