Research on the Relationship between Non-alcoholic Fatty Liver Disease and Hyperuricemia in Adults_West China Medical Journal

Authors：

QIN Ken ¹ , MA Xiuying ² , ZHOU Ting ¹ , ZHANG Fan ¹ , WU Qinqin ¹ , ZENG Li ¹ , YANG Ying ¹ , HUANG Yan ¹ , ZOU Tianfu ¹ , LI li ¹ ,  WANG Youjuan ¹

1. West China Hospital; 2. College of Basic and Forensic Medicine; Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

WANG Youjuan, Email: standardmeg@163.com

Keywords：

非酒精性脂肪肝; 高尿酸血症; 成年人

DOI：

CNKI: 51-1356/R.20120214.1531.046

Video：

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目的　了解成都地区非酒精性脂肪肝（NAFLD）及高尿酸血症（HUA）患病情况及相关因素。方法　对2010年9月－2011年3月健康体检的36 000名18岁以上受检者，进行病史采集、体格检查、空腹血糖、血脂、肝功能、肾功能、血尿酸检测以及上腹部彩色多普勒超声检查。结果　高尿酸血症（HUA）的总患病率为18.17%。NAFLD患者HUA患病率为39.41%，明显高于总患病率（P＜0.01）。NAFLD患者的HUA患病率随体质量指数（BMI）的增加呈递增趋势。BMI、舒张压、甘油三酯、胆固醇、丙氨酸转氨酶、门冬氨酸氨转移酶、谷氨酰转肽酶、血肌酐、胱抑素C均随着血尿酸水平的升高而递增；高密度脂蛋白随着血尿酸水平的升高而递减。结论　NAFLD及HUA关系密切，且二者与代谢紊乱联系紧密。

Citation： QIN Ken,MA Xiuying,ZHOU Ting,ZHANG Fan,WU Qinqin,ZENG Li,YANG Ying,HUANG Yan,ZOU Tianfu,LI li,WANG Youjuan. Research on the Relationship between Non-alcoholic Fatty Liver Disease and Hyperuricemia in Adults. West China Medical Journal, 2012, 27(2): 226-229. doi: CNKI: 51-1356/R.20120214.1531.046 Copy

1.	张华捷, 庄辉, 刘学恩. 脂肪肝的流行病学研究进展[J]. 中华流行病学杂志, 2004, 25(7): 630-631．.
2.	中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南[J].中华肝脏病杂志, 2006, 14(3): 161-163．.
3.	林果为,俞茂华. 新编诊断学基础[M].上海:复旦大学出版社, 2003: 7.
4.	曾瑶池, 黄鑫, 周光宇, 等.高尿酸血症在长沙市2 340名公务员中的患病情况及其相关因素分析[J]. 卫生研究, 2008, 37(6): 679-681.
5.	沈泓, 陆维, 华嘉临. 无锡地区14 485名居民高尿酸血症患病率及相关危险因素分析[J]. 苏州大学学报(医学版), 2010, 30(3): 582-583.
6.	Duvnjak M, Leroti I, Barsi N, et al. Pathogenesis and management issues for non-alcoholic fatty liver disease[J]. World J Gastroenterol, 2007, 13(34): 4539-4550.
7.	Lonardo A, Caldwell S, Loria P. Clinical physiology of NAFLD: a critical overview of pathogenesis and treatment.Expert Review of Endocrinology & Metabolism, 2010, 5(3): 403-423.
8.	Rashid S, Watanabe T, Sakaue T, et al. Mechanisms of HDL lowering in insulin resistant,hypertriglyceridemic states: the combine deffect of HDL triglyceride enrichment and elevated hepatic lipase activity[J]. Clin Biochem, 2003, 36(6): 421-429.
9.	Luyckx FH， Lefebvre PJ， Scheen AJ. Non-alconolic steatohepatitis: association with obesity and insulin resistance,and influence of weight loss[J]. Diabetes Metab, 2000, 26(2): 98-106.
10.	周卫东，车志宏，杨亚玲. 成人非酒精性脂肪肝与代谢综合征关系的研究[J].中国实用内科杂志, 2008, 28(8): 641-643.
11.	HuangHL, LinWY, Lee LT, et al. Metabolic syndrome is related to nonalcoholic steatoh epatitis in severely obese subjects [J]. Obes Surg, 2007, 17(11): 1457-1463.
12.	Onat A, Uyarel H, Hergenc G, et al. Serum uric acid is a determinant of metabolic syndrome in a population based study[J]. AM J Hypertens, 2006, 19(10): 1055-1062.

1. 张华捷, 庄辉, 刘学恩. 脂肪肝的流行病学研究进展[J]. 中华流行病学杂志, 2004, 25(7): 630-631．.
2. 中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南[J].中华肝脏病杂志, 2006, 14(3): 161-163．.
3. 林果为,俞茂华. 新编诊断学基础[M].上海:复旦大学出版社, 2003: 7.
4. 曾瑶池, 黄鑫, 周光宇, 等.高尿酸血症在长沙市2 340名公务员中的患病情况及其相关因素分析[J]. 卫生研究, 2008, 37(6): 679-681.
5. 沈泓, 陆维, 华嘉临. 无锡地区14 485名居民高尿酸血症患病率及相关危险因素分析[J]. 苏州大学学报(医学版), 2010, 30(3): 582-583.
6. Duvnjak M, Leroti I, Barsi N, et al. Pathogenesis and management issues for non-alcoholic fatty liver disease[J]. World J Gastroenterol, 2007, 13(34): 4539-4550.
7. Lonardo A, Caldwell S, Loria P. Clinical physiology of NAFLD: a critical overview of pathogenesis and treatment.Expert Review of Endocrinology & Metabolism, 2010, 5(3): 403-423.
8. Rashid S, Watanabe T, Sakaue T, et al. Mechanisms of HDL lowering in insulin resistant,hypertriglyceridemic states: the combine deffect of HDL triglyceride enrichment and elevated hepatic lipase activity[J]. Clin Biochem, 2003, 36(6): 421-429.
9. Luyckx FH， Lefebvre PJ， Scheen AJ. Non-alconolic steatohepatitis: association with obesity and insulin resistance,and influence of weight loss[J]. Diabetes Metab, 2000, 26(2): 98-106.
10. 周卫东，车志宏，杨亚玲. 成人非酒精性脂肪肝与代谢综合征关系的研究[J].中国实用内科杂志, 2008, 28(8): 641-643.
11. HuangHL, LinWY, Lee LT, et al. Metabolic syndrome is related to nonalcoholic steatoh epatitis in severely obese subjects [J]. Obes Surg, 2007, 17(11): 1457-1463.
12. Onat A, Uyarel H, Hergenc G, et al. Serum uric acid is a determinant of metabolic syndrome in a population based study[J]. AM J Hypertens, 2006, 19(10): 1055-1062.

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West China Medical Journal

Research on the Relationship between Non-alcoholic Fatty Liver Disease and Hyperuricemia in Adults

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