Objective To detect the levels and study the significance of serum soluble intercellular adhension molecule-1(sVCAM-1),soluble vascular cell adhension molecule-1 (sVCAM-1) in patients with community-acquired pneumonia(CAP).Methods sICAM-1 and sVCAM-1 were detected by enzymelinked immunosorbent assy（ELISA）in 25 patients with CAP before and after treatment as well as in 10 healthy controls.Results Before treatment, the levels of serum sICAM-1 and sVCAM-1 in the patients with CAP[（2.658 4±0.259 7）ng/mL,(2.680 9±0.255 4）ng/mL)] were significantly higher than those in controls[(2.472 8±0.077 6)ng/mL,（2.426 3±0.307 2)ng/mL](P lt;0.01,P lt;0.05). After treatment, the levels of serum sICAM-1, sVCAM-1 significantly decreased [(2.518 3±0.205 2)ng/mL,(2.523 0±0.279 4)ng/mL](P lt;0.01,P lt;0.01) and were not different from those in controls（P gt;0.05）.The levels of sICAM-1 were positively associated with neutrophil counts（r=0.602，P lt;0.001）rather than the levels of sVCAM-1（r＝0.036，P gt;0.05）.Conclusion The changes of sICAM-1 and sVCAM-1 before and after treatment are predictive to the prognosis in patients with CAP.
Citation：
CHEN Yusheng,XIE Baosong,LIN Ming,XU Nengluan,LIN Zhangshu,LI Ruihui,LI Hongru,LIN Lifang. Significance of serum soluble intercellular adhension molecule-1 and soluble vascular cell adhension molecule-1 in patients with community-acquired pneumonia. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(1): 26-29. doi:
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Copyright © the editorial department of Chinese Journal of Respiratory and Critical Care Medicine of West China Medical Publisher. All rights reserved
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Demir T，Yalçinoz C，Keskinel I，et al.sICAM-1 as a serum marker in the diagnosis and follow-up of treatment of pulmonary tuberculosis.Int J Tuberc Lung Dis，2002，6：155-159.
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Hansen AB，Verder H，Staun-Olsen P.Soluble intercellular adhesion molecule and C-reactive protein as early markers of infection in newborns.J Perinat Med，2000，28：97-103.
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Koizumi A，Hashimoto S，Kobayashi T，et al.Elevation of serum soluble vascular cell adhesion molecule-1 (sVCAM-1) levels in bronchial asthma.Clin Exp Immunol，1995，101：468-473.
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陈晓东，王顺宾，江琼，等.严重烧伤患者血清sICAM-1和sVCAM-1水平的变化及与感染的关系.中国急救医学，2004，24：109-111.
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Südhoff T，Wehmeier A，Arning M，et al.Increases of sICAM-1 during neutropenic pneumonia in leukemic patients.Leukemia，1997，11：346-351.
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Glynn P，Coakley R，Kilgallen I，et al.NeutroPhil CD11b and soluble ICAM-1 and E-selectin in community acquired Pneumonia.Eur Respir J，1999，13：1380-1385.
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叶璟，何时军，严纯雪，等.肺炎患儿血清可溶性细胞间黏附分子-1的变化及意义.实用医学杂志，2005，21：1150-1151.
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Kobayashi T，Hashimoto S，Imai K，et al.Elevation of serum soluble intercellular adhesion molecule-1 (sICAM-1) and sE-selectin levels in bronchial asthma.Clin Exp Immunol，1994，96：110-115.
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| 9. |
Zhou Z，Liu Y，Miao AD，et al.Protocatechuic aldehyde suppresses TNF-alpha-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells.Eur J Pharmacol，2005，513：1-8.
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| 10. |
Hayashi T，Hasegawa K，Ichinohe N，et al.ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 mice.Histol Histopathol，2005，20：45-52.
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Yang L，Froio RM，Sciuto TE，et al.ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.Blood，2005，106：584-592.
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Murata K，Takayanagi T，Mano Y，et al.Serum levels of soluble adhesion molecules in patients with inflammatory myopathi.Rinsho Shinkeigaku，1996，36：12-16.
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| 13. |
宋金枝，文飞球，周克英，等.新生儿细菌感染血淋巴细胞ICAM-1和L-selectin的变化及意义.中国感染控制杂志，2004，3：208-210.
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| 14. |
Spark JI，Scott DJ，Chetter IC，et al.Does soluble intercellular adhesion molecule-1 (ICAM-1) affect neutrophil activation and adhesion following ischaemia-reperfusion? Eur J Vasc Endovasc Surg，1999，17：115-120.
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| 15. |
Harlan JM，Winn RK.Leukocyte-endothelial interactions：clinical trials of anti-adhesion therapy.Crit Care Med，2002，30：S214-S219.
|
- 1. Demir T，Yalçinoz C，Keskinel I，et al.sICAM-1 as a serum marker in the diagnosis and follow-up of treatment of pulmonary tuberculosis.Int J Tuberc Lung Dis，2002，6：155-159.
- 2. Hansen AB，Verder H，Staun-Olsen P.Soluble intercellular adhesion molecule and C-reactive protein as early markers of infection in newborns.J Perinat Med，2000，28：97-103.
- 3. Koizumi A，Hashimoto S，Kobayashi T，et al.Elevation of serum soluble vascular cell adhesion molecule-1 (sVCAM-1) levels in bronchial asthma.Clin Exp Immunol，1995，101：468-473.
- 4. 陈晓东，王顺宾，江琼，等.严重烧伤患者血清sICAM-1和sVCAM-1水平的变化及与感染的关系.中国急救医学，2004，24：109-111.
- 5. Südhoff T，Wehmeier A，Arning M，et al.Increases of sICAM-1 during neutropenic pneumonia in leukemic patients.Leukemia，1997，11：346-351.
- 6. Glynn P，Coakley R，Kilgallen I，et al.NeutroPhil CD11b and soluble ICAM-1 and E-selectin in community acquired Pneumonia.Eur Respir J，1999，13：1380-1385.
- 7. 叶璟，何时军，严纯雪，等.肺炎患儿血清可溶性细胞间黏附分子-1的变化及意义.实用医学杂志，2005，21：1150-1151.
- 8. Kobayashi T，Hashimoto S，Imai K，et al.Elevation of serum soluble intercellular adhesion molecule-1 (sICAM-1) and sE-selectin levels in bronchial asthma.Clin Exp Immunol，1994，96：110-115.
- 9. Zhou Z，Liu Y，Miao AD，et al.Protocatechuic aldehyde suppresses TNF-alpha-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells.Eur J Pharmacol，2005，513：1-8.
- 10. Hayashi T，Hasegawa K，Ichinohe N，et al.ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 mice.Histol Histopathol，2005，20：45-52.
- 11. Yang L，Froio RM，Sciuto TE，et al.ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.Blood，2005，106：584-592.
- 12. Murata K，Takayanagi T，Mano Y，et al.Serum levels of soluble adhesion molecules in patients with inflammatory myopathi.Rinsho Shinkeigaku，1996，36：12-16.
- 13. 宋金枝，文飞球，周克英，等.新生儿细菌感染血淋巴细胞ICAM-1和L-selectin的变化及意义.中国感染控制杂志，2004，3：208-210.
- 14. Spark JI，Scott DJ，Chetter IC，et al.Does soluble intercellular adhesion molecule-1 (ICAM-1) affect neutrophil activation and adhesion following ischaemia-reperfusion? Eur J Vasc Endovasc Surg，1999，17：115-120.
- 15. Harlan JM，Winn RK.Leukocyte-endothelial interactions：clinical trials of anti-adhesion therapy.Crit Care Med，2002，30：S214-S219.
