Objective To study the effects of hemodilution on oxygenation during one-lung ventilation(OLV).Methods Forty patients undergoing lung surgery with or without chronic obstructive pulmonary disease（COPD）were enrolled.The study was performed in the supine position before surgery.The tracheas were intubated with a double-lumen tube.OLV was initiated for 15 min.After 15 min of OLV，arterial and venous blood gas samples were collected and analyzed.The cardiac output (CO) was measured.Two-lung ventilation was reinstituted，and hemodilution was performed (6% hydroxyethyl starch，10 mL/kg).Subsequently，OLV was performed again for 15 min.Then arterial and venous blood gas samples were collected and analyzed.The cardiac output (CO) was measured.Results Hemodilution resulted in a significant and similar decrease in HB concentration in patients both with or without COPD.However，hemodilution resulted in a significant decrease in PaO2 in COPD patients rather than subjects without COPD.Conclusion Mild hemodilution impairs gas exchange during OLV in COPD patients.
Citation： JIANG Xiaoqin,LIN Xuemei,MA Yushan,YIN Yan,LIU Jin. The effects of acute hemodilution on oxygenation during one-lung ventilation in patients with chronic obstructive pulmonary disease. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(2): 101-103. doi: Copy