Objective  To investigate the therapeutic effects of strontium-89 to prevent bone metastases of lung neoplasms.Methods  Thirty patients with bone metastases of lung neoplasms received strontium-89 treatment (89SrCl2) at a dose of 148 MBq through intravenous injection.The analgesic effect was assessed by VAS method and doses or frequency of using analgesic drugs.Other efficacy parameters included changes in the number of osseous lesions and urinary levels of pyridinoline and deoxypyridinoline on the day 28 after therapy.Results  The total pain relief rate was 73.3%(22/30)，among which 5(16.6%) cases with pain vanished，suggesting significant alleviation of the pain intensity by the treatment(P lt;0.001) on the day 28 after therapy.The number of lesions decreased in 16 cases with effective rate of 53.3%，showing the bone metastases significantly decreased after the therapy (P lt;0.001).The urinary levels of pyridinoline and deoxypyridinoline on the day 28 after therapy were (62.48±37.25)nmol/mmol Cr and (13.94±8.66)nmol/mmol Cr，respectively，which were decreased significantly compared to the levels before treatment which were (100.15±48.65)nmol/mmol Cr and (31.25±15.32)nmol/mmol Cr，respectively (both P lt;0.001).Conclusion  Strontium-89 is effective to relieve pain and prevent bone lesions in patients with bone metastases of the lung neoplasms.

Citation： XU Jie,CHEN Xiao. Therapeutic effects of strontium-89 to prevent bone metastases of lung neoplasms：A clinical analysis of 30 cases. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(2): 104-106. doi: Copy