Short-term effects of percutaneous microwave coagulation therapy combined with chemotherapy in the treatment of advanced non-small cell lung cancer_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

TI Xinyu , LI Shengqing , LIU Aru , OUYANG Haifeng , ZHAO Feng ,  WU Changgui

Department of Respiratory Medicine，Xijing Hospital，Fourth Military Medical University.Xi’an，Shanxi，710032，ChinaCorresponding author：E-mail：changgui@fmmu.edu.cn;

Corresponding author：

WU Changgui, Email: changgui@fmmu.edu.cn

Keywords：

Non-small cell lung cancer; Percutaneous microwave coagulation therapy; Chemotherapy; Quality of life; Comparative study

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Objective To evaluate short-term effects of percutaneous microwave coagulation therapy（PMCT） combined with chemotherapy in patients with advanced non-small cell lung cancer（NSCLC）.Methods Eighty cases with advanced NSCLC were randomly assigned to underwent chemotherapy plus PMCT(PMCT group，n=40) or single chemotherapy(chemotherapy group，n=40).The chemotherapeutics regimen was Taxotere plus Cisplatin.The preliminary results and quality of life score of two groups were compared.Results In PMCT group and chemotherapy group，the 3-month relieve rate was 52.5% and 32.5%，and the half-year survival rate was 87.5% and 62.5%，respectively.The differences between the two groups were both significant(P lt;0.05).The quality of life score in PMCT group was significantly higher than that in chemotherapy group (P lt;0.05).Conclusion PMCT combined with chemotherapy is effective and safe in the treatment of advanced NSCLC.

Citation： TI Xinyu ,LI Shengqing,LIU Aru,OUYANG Haifeng,ZHAO Feng,WU Changgui. Short-term effects of percutaneous microwave coagulation therapy combined with chemotherapy in the treatment of advanced non-small cell lung cancer. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(3): 174-176. doi: Copy

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1. El·Sherif A，Luketich JD，Landreneau RJ，et al.New therapeutic approaches for early stage non·small cell lung cancer.Surg Oncol，2005，14：27-32.
2. Dupuy DE，Zagoria RJ，Akerley W，et al.Percutaneous radiofrequency tissue ablation malignancies in the lung.AJR，2000，174：57-59.
3. Simon CJ，Dupuy DE．Current role of image·guided ablative therapies in lung cancer.Expert Rev Anticancer Ther，2005，5：657-666.
4. Lu S，Liao ML，Shen J，et al.The possibility to establish the scale of quality life fit for Chinese lung cancer patients.Chin J Lung Cancer，2001，4：344-346.
5. 孙燕，周际昌，主编.临床肿瘤内科手册.北京：人民卫生出版社，2003，34-37.
6. Wright AS，Lee FT Jr，Mahvi DM.Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis.Ann Surg Oncol，2003，10：275-283.
7. Dong BW，Zhang J，Liang P，et al.Sequential pathological and immunologic analysis of percutaneous microwave coagulation therapy of hepatocellular carcinoma.Int J Hyperthermia，2003，19：119-133.
8. Zhang J，Dong B，Liang P，et al.Significance of changes in local immunity in patients with hepatocellular carcinoma after percutaneous microwave coagulation therapy.Chin Med J(Engl)，2002，115：1367-1371.
9. 周彩存.晚期肺癌的姑息治疗.中国呼吸与危重监护杂志，2005，4：177-178.

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Short-term effects of percutaneous microwave coagulation therapy combined with chemotherapy in the treatment of advanced non-small cell lung cancer

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