Clinicoradiologic features of cryptogenic organizing pneumonia_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHOU Fengqiu ¹ ,  CAI Hourong ¹ , CAO Ming ¹ , MENG Fanqing ² , DAI Lingjuan ¹

Department of Respiratory Medicine ， The Affiliated Drum Tower Hopital ， Nanjing University Medical College.Nanjing ， Jiangsu ， 210008 ， ChinaCorresponding author ： CAI Hou-rong ， E-mail ： caihourong@yahoo.com.cn;

Corresponding author：

CAI Hourong, Email: caihourong@yahoo.com.cn

Keywords：

Cryptogenic organizing pneumonitis; Imageology; Computerized tomography; Open lung biopsy

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Objective To analyze the clinical presentations and radiological characteristics of pathologically proved cases of cryptogenic organizing pneumonia(COP).Methods The clinical and radiological features of 8 patients with COP confirmed by open lung biopsy were analyzed.Treatment and follow-up data were also recorded.Results There were 5 male an 3 female patients aged 37 to 68 years.Dyspnea，cough and inspiratory crackles were the most common symptoms and signs.Various computed tomography findings including ground glass opacities,pathy consolidation with air bronchograms，nodules and reticulation were simultaneously observed in the same patient.The diagnostic imaging features of COP were patchy or lobar consolidation，often by a predominantly subpleural distribution，and irregular band-like opacities distributed along the bronchovascular bundle or located in the subpleural area.All patients were treated with corticosteroids and yielded significant improvement in seven cases.Conclusions COP could be diagnosed by clinical and radiological findings and histopathological examination was needed for confirmed diagnosis.In general，COP responds well to glucocorticoid therapy and has a benign prognosis.

Citation： ZHOU Fengqiu,CAI Hourong,CAO Ming,MENG Fanqing,DAI Lingjuan. Clinicoradiologic features of cryptogenic organizing pneumonia. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(4): 277-280. doi: Copy

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6.	Ujita M，Renzoni EA，Veeraraghavan S，et al.Organizing pneumonia：perilobular pattern at thin-section CT.Radiology，2004，232：757-761.
7.	施举红，许文兵，刘鸿瑞，等.隐源性机化性肺炎18例的临床病理特征.中华结核和呼吸杂志，2006，29：167-170.
8.	徐健，宋伟，金征宇.隐原性机化性肺炎的影像学特点.中国医学科学院学报，2006，28：58-60.
9.	朱晓华，李天女，尤正千，等.隐原性机化性肺炎的CT影像学特征及激素治疗后的改变.中华结核和呼吸杂志，2006，29：658-661.
10.	Colby TV.Pathologic aspects of bronchiolitis obliterans organizing pneumonia.Chest，1992，102(1 Suppl)：38S-43S.
11.	Davison AG，Heard BE，McAllister WA，et al.Crypogenic organizing pneumonitis.Q J Med，1983，52：382-394.
12.	Epler GR，Colby TV，McLoud TC，et al.Bronchiolitis obliterans organizing pneumonia.N Engl J Med，1985，312：152-158.
13.	Johkoh T，Müller NL，Cartier Y，et al.Idiopathic interstitial pneumonias：diagnostic accuracy of thin-section CT in 129 patients.Radiology，1999，211：555-560.
14.	蔡后荣，周贤梅，孟凡青，等.闭塞性细支气管炎伴机化性肺炎的临床和影像学研究.中国呼吸与危重监护杂志，2005，4：135-137.
15.	Lynch DA，Travis WD，Müller NL，et al.Idiopathic interstitial pneumonias：CT features.Radiology，2005，236：10-21.

1. American Thoracic Society，European Respiratory Society.American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias.This joint statement of the American Thoracic Society (ATS)，and the European Respiratory Society (ERS) was adopted by the ATS board of directors，June 2001 and by the ERS Executive Committee，June 2001.Am J Respir Crit Care Med，2002，165：277-304.
2. Cordier JF.Cryptogenic organising pneumonia.Eur Respir J，2006，28：422-446.
3. Cordier JF，Loire R，Brune J.Idiopathic bronchiolitis obliterans organizing pneumonia.Definition of characteristic clinical profiles in a series of 16 patients.Chest，1989，96：999-1004.
4. Lee KS，Kullnig P，Hartman TE，et al.Cryptogenic organizing pneumonia：CT findings in 43 patients.AJR Am J Roentgenol，1994，162：543-546.
5. Akira M，Yamamoto S，Sakatani M.Bronchiolitis obliterans organizing pneumonia manifesting as multiple large nodules or masses.AJR Am J Roentgenol，1998，170：291-295.
6. Ujita M，Renzoni EA，Veeraraghavan S，et al.Organizing pneumonia：perilobular pattern at thin-section CT.Radiology，2004，232：757-761.
7. 施举红，许文兵，刘鸿瑞，等.隐源性机化性肺炎18例的临床病理特征.中华结核和呼吸杂志，2006，29：167-170.
8. 徐健，宋伟，金征宇.隐原性机化性肺炎的影像学特点.中国医学科学院学报，2006，28：58-60.
9. 朱晓华，李天女，尤正千，等.隐原性机化性肺炎的CT影像学特征及激素治疗后的改变.中华结核和呼吸杂志，2006，29：658-661.
10. Colby TV.Pathologic aspects of bronchiolitis obliterans organizing pneumonia.Chest，1992，102(1 Suppl)：38S-43S.
11. Davison AG，Heard BE，McAllister WA，et al.Crypogenic organizing pneumonitis.Q J Med，1983，52：382-394.
12. Epler GR，Colby TV，McLoud TC，et al.Bronchiolitis obliterans organizing pneumonia.N Engl J Med，1985，312：152-158.
13. Johkoh T，Müller NL，Cartier Y，et al.Idiopathic interstitial pneumonias：diagnostic accuracy of thin-section CT in 129 patients.Radiology，1999，211：555-560.
14. 蔡后荣，周贤梅，孟凡青，等.闭塞性细支气管炎伴机化性肺炎的临床和影像学研究.中国呼吸与危重监护杂志，2005，4：135-137.
15. Lynch DA，Travis WD，Müller NL，et al.Idiopathic interstitial pneumonias：CT features.Radiology，2005，236：10-21.

Chinese Journal of Respiratory and Critical Care Medicine

Clinicoradiologic features of cryptogenic organizing pneumonia

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