Efects of closed airway management on distribution and drug susceptibility of pathogenic bacteria in lower respiratory tract of mechanical ventilated patients_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 LIU Ning ¹ , LIU Jianying ² , GU Qin ¹

Intensive Care Unit,The Affiliated Drum-tower Hospital of Medical School,Nanjing Univerity.Nanfing,Jiangsu.210008, china Corresponding author：LIU Ning,E-mail：aliuning@ sohu.com;

Corresponding author：

LIU Ning , Email: aliuning@sohu.con

Keywords：

Closed airway management; Lower respiratory tract; Pathogen; Colonization; Drug resistance

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0bjective To compare the effect of closed airway management system and open suction system on distribution and drug susceptibility of pathogenic bacteria in lower respiratory tract of mechanical ventilated patients.Methods Fifty-nine cases in ICU who received mechanical ventilation for more than 48 h from May 2006 to Dec 2006 were randomly divided into two groups.Group A(29 patients)received closed—tracheal suction and Group B(30 patients)received open-tracheal suction.Quantitative bacteriological culture and sensitivity of antibacterial drugs were conducted on lower respiratory tract secretion samples.Results In group A，a total of 91 strains were isolated，in which a single pathogen infection(41.4％)was the most frequent，followed by mixed infection of two pathogens(34.5％)and three or more pathogens(24.1％).In group B，a total of 141 strains were isolated，in which three or more pathogen infection(53.33％)was the most frequent，followed by two pathogen infection(30％)and a single pathogen infection(16.7％ ).Pathogen distribution between the two groups was not significantly different(P gt;0.05).Drug susceptibility test did not show significant difference in main pathogens between the two groups(P gt;0.05).Conclusions Closed airway management system can reduce the infection or colonization of mixed pathogens，but can not change the distribution and drug susceptibility of pathogens.

Citation： LIU Ning ,LIU Jianying,GU Qin. Efects of closed airway management on distribution and drug susceptibility of pathogenic bacteria in lower respiratory tract of mechanical ventilated patients. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(6): 427-430. doi: Copy

1.	Bauer TT,Ferrer R,Angrill J.et al.Ventilator.associated pneumonia：incidence,risk factors,and microbiology.Semin Respir Infect,2000,15：272-279.
2.	杨冠华,王煜,胡雪君,等.30例呼吸机相关肺炎病原学与临床分析.中国呼吸与危重监护杂志,2004,3：317.
3.	李华茵,何礼贤,胡必杰,等.重症监护病房呼吸机相关肺炎临床与病原学分析.中国呼吸与危重监护杂志,2005,4：266~70.
4.	Cook D.Ventilator-associated pneumonia：perspectives on the burden of illness.Intensive Care Med,2000,26(Suppl 1)：S31-$37.
5.	Keenan SP,Heyland DK,Jacka MJ,et al.Ventilator-associated pneu- monia.Prevention,diagnosis,and therapy.Crit Care Clin,2002,1 8： 107-125.
6.	甘枚,黄捷敏.呼吸机相关肺炎危险因素探讨.中国呼吸与危重监护杂志,2006,5：175-177.
7.	Dodek P,Keenan S,Heyland DK,et al.Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia.Ann Intem Med,2004,17：141：305-313.
8.	Safdar N,Cmieh CJ,Maki DG.The pathogenesis of ventilator assoeiated pneumonia：its relevance to developing effective strategies for prevention.Respir Care,2005,50：725-741. 9 刘朝晖,陈劲龙.广州地区呼吸机相关性肺炎临床流行病学和病原学分析.中国呼吸与危重监护杂志,2007,6：93-96.
9.	岳文香,黄绍光,李敏,等.呼吸功能不全患者下呼吸道感染菌的研究.中华医院感染学杂志,2003,13：750-752.
10.	刘鲁沂,朱永健,于守丽,等.重症监护病房患者下呼吸道感染的流行病学调查及耐药性分析.中华医院感染学杂志,2002, 12：388-390.
11.	吴安华,罗晓燕.铜绿假单胞菌多重药物主动外排泵与抗生素耐药.中华医院感染学杂志,2003,13：93-95.
12.	熊薇,孙自镛,申正义.铜绿假单胞菌的耐药性及其耐氟喹诺酮机制的研究.中华医院感染学杂志,2003,13：204-206.

1. Bauer TT,Ferrer R,Angrill J.et al.Ventilator.associated pneumonia：incidence,risk factors,and microbiology.Semin Respir Infect,2000,15：272-279.
2. 杨冠华,王煜,胡雪君,等.30例呼吸机相关肺炎病原学与临床分析.中国呼吸与危重监护杂志,2004,3：317.
3. 李华茵,何礼贤,胡必杰,等.重症监护病房呼吸机相关肺炎临床与病原学分析.中国呼吸与危重监护杂志,2005,4：266~70.
4. Cook D.Ventilator-associated pneumonia：perspectives on the burden of illness.Intensive Care Med,2000,26(Suppl 1)：S31-$37.
5. Keenan SP,Heyland DK,Jacka MJ,et al.Ventilator-associated pneu- monia.Prevention,diagnosis,and therapy.Crit Care Clin,2002,1 8： 107-125.
6. 甘枚,黄捷敏.呼吸机相关肺炎危险因素探讨.中国呼吸与危重监护杂志,2006,5：175-177.
7. Dodek P,Keenan S,Heyland DK,et al.Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia.Ann Intem Med,2004,17：141：305-313.
8. Safdar N,Cmieh CJ,Maki DG.The pathogenesis of ventilator assoeiated pneumonia：its relevance to developing effective strategies for prevention.Respir Care,2005,50：725-741. 9 刘朝晖,陈劲龙.广州地区呼吸机相关性肺炎临床流行病学和病原学分析.中国呼吸与危重监护杂志,2007,6：93-96.
9. 岳文香,黄绍光,李敏,等.呼吸功能不全患者下呼吸道感染菌的研究.中华医院感染学杂志,2003,13：750-752.
10. 刘鲁沂,朱永健,于守丽,等.重症监护病房患者下呼吸道感染的流行病学调查及耐药性分析.中华医院感染学杂志,2002, 12：388-390.
11. 吴安华,罗晓燕.铜绿假单胞菌多重药物主动外排泵与抗生素耐药.中华医院感染学杂志,2003,13：93-95.
12. 熊薇,孙自镛,申正义.铜绿假单胞菌的耐药性及其耐氟喹诺酮机制的研究.中华医院感染学杂志,2003,13：204-206.

Chinese Journal of Respiratory and Critical Care Medicine

Efects of closed airway management on distribution and drug susceptibility of pathogenic bacteria in lower respiratory tract of mechanical ventilated patients

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