AppHcation of bronchial provocation test on etiological diagno~s of chronic cough_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHU Minli ,  CAI Boqiang

Department of Respiratory Medicine，Peking Union Medical College Hospita1．Beijng，100730，China;

Corresponding author：

CAI Boqiang, Email: caibq@hotmail.com

Keywords：

Chronic cough; Bronchial provocation test; Small airway function; Extrathoracic airway hyperesponsiveness

Video：

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Objective To investigate the changes of small airway function，airway resistance and responsiveness of extrathoracic airway in chronic cough patients before and after bronchial provocation test (BPT)．Methods 68 chronic cough patients were requested to conduct lung function test and BPT．The airw ay resistance were measured via forced oscillationary technology before and after BPT．Results BPT revealed airway hyperresponsiveness in 52％subjects．MEF50 and R0 before BPT were significantly different between the patients with or without airway hyperresponsiveness．Post BPT changes in MEF50(MEF50％) were correlated positively to the changes in FEV1(FEVl％)，and negatively to the changes in R0[Ro-d]． Extrathoracic airway hyperresponsivenes(EAHR)was f0und in13 patients，in which 6 patients were not revealed by routine BPT．Conclusion There is small airway function abnormalities in chronic cough patients．Extrathoracic airway responsiveness test is a valuable supplementary index to routine BPT．

Citation： ZHU Minli,CAI Boqiang. AppHcation of bronchial provocation test on etiological diagno~s of chronic cough. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(6): 445-447. doi: Copy

1.	1 Carney IK，Gibson PG，Murree-Allen K，et al．A systematic evaluation of mechanisms in chronic cough．Am J Respir Crit Mare Med.
2.	陈亚红，姚婉贞，柳晓芳，等．轻度哮喘患者在支气管激发试验前后小气道功能及弥散功能的改变．中国呼吸与危重监护杂志，2007，6：3-7.
3.	Brightling CE，Ward R，Wardlaw AJ，et al．Airway inflammation，airway responsiveness and cough before and after inhaled budesonide in patients with eosinophilic bronchitis．Eur Resplr J，2000，15：682-686.
4.	Christophe D，Hubert L，Martine H，et al．Use of the Forced Oscillation Technique to Assess Airway Obstruction and Reversibility in Children．Am J Respir Crit Care Med，2000，161：730-736.
5.	王志虹，李勇，黄铁群，等．支气管激发试验在慢性咳嗽诊断中的意义．中国呼吸与危重监护杂志，2007，6：245-248.
6.	Bucca C，Rolla G，Scappaticci E，et al．Histamine hyperresponsive- ness of the extrathoracic airw ay in pations with asthmatic symptoms．Allergy，1991，46：147-153.
7.	Ribeiro M，Pereira CA，Nery LE，et al．Methacholine 138 adenosine on intra and extrathoracic airway hyperresponsiveness in patients with cough variant asthma．Allergy ，2008，63：527-532.
8.	Turktas I，Dalgic N，Bostanci I，et al．Extrathoracic airway respon- siveness in children with asthma-like symptoms，including chronic persistent COUgh．Pediatr Pulmonol，2002，34：172-180. 9 Fernando M，Andrew B．Rhinosinusitis and asthma．Chest，1999， 1 15：550-556.
9.	Rolla G，Colagrande P，Magnano M，et al．Extrathoracic airway dys. function in cough associated with gastroesophageal reflux．J Allergy Clin Immunol，1998，102：204-209.
10.	Bucca C，Rolla G，Scappaticci E，et al．Extrathoracie and intrathoracic airway responsiveness in sinusitis．J Allergy Clin Immunol，1995，95：52-59.
11.	，156：211-216．.

1. 1 Carney IK，Gibson PG，Murree-Allen K，et al．A systematic evaluation of mechanisms in chronic cough．Am J Respir Crit Mare Med.
2. 陈亚红，姚婉贞，柳晓芳，等．轻度哮喘患者在支气管激发试验前后小气道功能及弥散功能的改变．中国呼吸与危重监护杂志，2007，6：3-7.
3. Brightling CE，Ward R，Wardlaw AJ，et al．Airway inflammation，airway responsiveness and cough before and after inhaled budesonide in patients with eosinophilic bronchitis．Eur Resplr J，2000，15：682-686.
4. Christophe D，Hubert L，Martine H，et al．Use of the Forced Oscillation Technique to Assess Airway Obstruction and Reversibility in Children．Am J Respir Crit Care Med，2000，161：730-736.
5. 王志虹，李勇，黄铁群，等．支气管激发试验在慢性咳嗽诊断中的意义．中国呼吸与危重监护杂志，2007，6：245-248.
6. Bucca C，Rolla G，Scappaticci E，et al．Histamine hyperresponsive- ness of the extrathoracic airw ay in pations with asthmatic symptoms．Allergy，1991，46：147-153.
7. Ribeiro M，Pereira CA，Nery LE，et al．Methacholine 138 adenosine on intra and extrathoracic airway hyperresponsiveness in patients with cough variant asthma．Allergy ，2008，63：527-532.
8. Turktas I，Dalgic N，Bostanci I，et al．Extrathoracic airway respon- siveness in children with asthma-like symptoms，including chronic persistent COUgh．Pediatr Pulmonol，2002，34：172-180. 9 Fernando M，Andrew B．Rhinosinusitis and asthma．Chest，1999， 1 15：550-556.
9. Rolla G，Colagrande P，Magnano M，et al．Extrathoracic airway dys. function in cough associated with gastroesophageal reflux．J Allergy Clin Immunol，1998，102：204-209.
10. Bucca C，Rolla G，Scappaticci E，et al．Extrathoracie and intrathoracic airway responsiveness in sinusitis．J Allergy Clin Immunol，1995，95：52-59.
11. ，156：211-216．.

Chinese Journal of Respiratory and Critical Care Medicine

AppHcation of bronchial provocation test on etiological diagno~s of chronic cough

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