Effect of immune-enhancing enteral nutrition on inflammatory reaction and immune function in the rats of ventilation-induced lung injury_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

XIAN Lewu ¹ ,  LIANG Zongan ²

Intensive Care Unit，Affiliated Tumor Hospital of Guangzhou Medical College．Guangzhou，Guangdong，510095，ChinaCorresponding author：LIANG Zong-an，E-mail：liangzongan@ hotmail.corn;

Corresponding author：

LIANG Zongan, Email: liangzongan@hotmail.com

Keywords：

Immune-enhancing enteral nutrition; Ventilation—induced lung injury; Imflammation; Immunological functi

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Objective To investigate the effects of immune—enhancing enteral nutritioin therapy on the inflammatory reaction and immune function in the rats of ventilation-induced lung injury．Methods Fourty rats were divided into four groups(EN1、EN2、SEN1、SEN2，n=10)．All groups were performed mechanic ventilation and fed isocaloric enteral nutrition．EN1 group：tidal Volume(VT) =8 mL／kg，traditional enteral nutrition；EN2 group：VT=40 mL／kg，traditional enteral nutrition；SEN1 group：VT：8 mL／kg，immune-enhancing enteral immunonutrition；SEN2 group：VT=40 mL／kg，immune-enhancing enteral immunonutrition．Lymphocyte subsets，TNF-α，IL-6 and contents of arachidonic acid(AA)were determined at different time point(0，4，24，72 h after ventilation)．Results The levels of CD3+，CD4+，CD4+／CD8+ in SEN2 group were lower(P lt;0.05)than in EN1，EN2 and SEN1 group after 24，72 h of ventilation．The serum concentrations of TNF-α，IL-6 and AA were significantly lower in EN2 than in other three groups(P lt;0.05)．Conclusion Immune-enhancing enteral nutrition feeding prior to machanie ventilatioin can alleriate the damage of immunological function and reduce infl ammotory responses

Citation： XIAN Lewu,LIANG Zongan. Effect of immune-enhancing enteral nutrition on inflammatory reaction and immune function in the rats of ventilation-induced lung injury. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(6): 455-458. doi: Copy

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1. Tremblay LN，Slutsky AS．Pathogenesis of ventilator-indeced lung injury：trials and tribulations．Am J Physiol Lung Cell Mol Physiol，2O05，288：1596-1598．.
2. Held HD，Boettcher S，Hamann L，et al．Ventilation-induced chemokine and cytokine release is associated with activation of nuclear factor-kappa B and is blocked by steroids．Am J Respir Crit Care Med，2001，163：711-716．.
3. Karzai W ，Cui XZ，Heinicke N，et a1．Neutrophil stimulation with granulocyte c010nystimu1ating factor worsens ventilator-induced lung injury and mortality in rats．Anesthesiology，2005，103：996-1005．.
4. Copland IB．Post M．Stretch-activated signaling pathways responsible for early response gene expression in fetal lung epithlial ceils．J Cell Physiol，2007，210：1 33-143．.
5. 陈灏珠，主编．实用内科学．北京：人民卫生出版社，2006，12．.
6. Chu EK，Whitenhead T，Shtsky AS．Effects of cyclic openm’g and closing at low-and high-volume ventilation on bronehoalveolar lavage cytokines．Crit Care Med，2004，32：168-174．.
7. Beale RJ，Bryg DJ，Bihari DJ．Immunonutrition in the critically ill：a systematic review of clinical outcome．Care Med，1999，27：2799-2805．.
8. Hayashi Y，Sawa Y，Fukuyama N，et al．Preoperative glutamine administration induces heat-shock protein 70 expression and attenuates cardiopulmonary bypass-induced inflammatory response by regulating nutric oxide synthase activity．Circulation，2002，106：2601-2607．.
9. Macdonald J，Galley HF，Webster NR．Oxidative stress and gene expression in sepsis．Br J Anaesth，2003，90：221-232．.
10. Alexander JW．Immunonutrition： the role of omega-3 fatty acids．Nutrition，1998，14：627-633．.

Chinese Journal of Respiratory and Critical Care Medicine

Effect of immune-enhancing enteral nutrition on inflammatory reaction and immune function in the rats of ventilation-induced lung injury

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