Progress on Immunology and Biotherapy of Respiratory Allergic Disease_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LIN Lihui ,  LI Li

Department of laboratory, First People’s Hospital Affiliated to Shanghai Jiaotong University. Shanghai, 200080, China;

Corresponding author：

LI Li, Email: annylish@hotmail.com

Keywords：

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Citation： LIN Lihui,LI Li. Progress on Immunology and Biotherapy of Respiratory Allergic Disease. Chinese Journal of Respiratory and Critical Care Medicine, 2009, 09(3): 300-302. doi: Copy

1.	Bousquet J，Dahl R，Khaltaev N.Global alliance against chronic respiratory diseases.Allergy，2007，62：216-223.
2.	Holgate S，Casale T，Wenzel S，et al.The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation.J Allergy Clin Immunol，2005，115：459-465.
3.	Bradding P，Walls AF，Holgate ST.The role of the mast cell in the pathophysiology of asthma.J Allergy Clin Immunol，2006，117：1277-1284.
4.	Cruse G，Kaur D，Yang W，et al.Activation of human lung mast cells by monomeric immunoglobulin E.Eur Respir J，2005，25：858-863.
5.	Slavin RG，Ferioli C，Tannenbaum SJ，et al.Asthma symptom re-emergence after omalizumab withdrawal correlates well with increasing IgE and decreasing pharmacokinetic concentrations.J Allergy Clin Immunol，2009，123：107-113.
6.	Lin H，Boesel KM，Griffith DT，et al.Omalizumab rapidly decreases nasal allergic response and FcepsilonRI on basophils.J Allergy Clin Immunol，2004，113：297-302.
7.	Djukanovi? R，Wilson SJ，Kraft M，et al.Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma.Am J Respir Crit Care Med，2004，170：583-593.
8.	Soler M.Anti-IgE antibodies in the treatment of allergic diseases.Allergol Immunol Clin，2002，42：45-49． 8 Hayashi N，Tsukamoto Y，Sallas WM，et al.A mechanism-based binding model for the population pharmacokinetics and pharmacodynamics of omalizumab.Br J Clin Pharmacol，2007，63：548-561.
9.	Dodig S，Richter D，Cepelak I.Anti-IgE therapy with omalizumab in asthma and allergic rhinitis.Acta Pharm，2005，55：123-138.
10.	Saxon A，Kepley CL，Zhang K，et al."Accentuate the negative，eliminate the positive"：engineering allergy therapeutics to block allergic reactivity through negative signaling.J Allergy Clin Immunol，2008，121：320-325.
11.	Kepley CL，Taghavi S，Mackay G，et al.Co-aggregation of FcgammaRII with FcepsilonRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes.J Biol Chem，2004，279：35139-35149.
12.	Daëron M，Malbec O，Latour S，et al.Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors.J Clin Invest，1995，95：577-585.
13.	Zhu D，Kepley CL，Zhang K，et al.A novel human immunoglobulin Fcγ–Fcε bifunctional fusion protein inhibits FcεRI-mediated degranulation.Nat med，2005，11：446-449.
14.	Zhang K，Kepley CL，Terada T，et al.Inhibition of allergen-specific IgE reactivity by a human Ig Fcγ-Fcε bifunctional fusion protein.J Allergy Clin Immunol，2004，114：321-327.
15.	Kepley CL，Zhang K，Zhu D，et al.Fc?RI-Fc?RII coaggregation inhibits IL-16 production from human Langerhans-like dendritic cells.Clin Immunol，2003，108：89-94.
16.	Yamada T，Zhu D，Zhang K，et al.Inhibition of interleukin-4-induced class switch recombination by a human immunoglobulin Fc?-Fc? chimeric protein.J Biol Chem，2003，278：32818-32824.
17.	Saxon A，Zhu D，Zhang K，et al.Genetically engineered negative signaling molecules in the immunomodulation of allergic diseases.Curr Opin Allergy Clin Immunol，2004，4：563-568.
18.	Allen LC，Kepley CL，Saxon A，et al.Modifications to an Fcgamma-Fcvarepsilon fusion protein alter its effectiveness in the inhibition of FcvarepsilonRI-mediated functions.J Allergy Clin Immunol，2007，120：462-468.
19.	Zhu D，Kepley CL，Zhang K，et al.A chimeric human-cat fusion protein blocks cat-induced allergy.Nat Med，2005，11：446-449.
20.	Zhang K，Zhu D，Kepley CL，et al.Chimeric human fcγ-allergen fusion proteins in the prevention of allergy.Immunol Allergy Clin North Am，2007，27：93-103.
21.	Terada T，Zhang K，Belperio J，et al.A chimeric human-cat Fcgamma-Fel d1 fusion protein inhibits systemic，pulmonary，and cutaneous allergic reactivity to intratracheal challenge in mice sensitized to Fel d1，the major cat allergen.Clin Immunol，2006，120：45-56.

1. Bousquet J，Dahl R，Khaltaev N.Global alliance against chronic respiratory diseases.Allergy，2007，62：216-223.
2. Holgate S，Casale T，Wenzel S，et al.The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation.J Allergy Clin Immunol，2005，115：459-465.
3. Bradding P，Walls AF，Holgate ST.The role of the mast cell in the pathophysiology of asthma.J Allergy Clin Immunol，2006，117：1277-1284.
4. Cruse G，Kaur D，Yang W，et al.Activation of human lung mast cells by monomeric immunoglobulin E.Eur Respir J，2005，25：858-863.
5. Slavin RG，Ferioli C，Tannenbaum SJ，et al.Asthma symptom re-emergence after omalizumab withdrawal correlates well with increasing IgE and decreasing pharmacokinetic concentrations.J Allergy Clin Immunol，2009，123：107-113.
6. Lin H，Boesel KM，Griffith DT，et al.Omalizumab rapidly decreases nasal allergic response and FcepsilonRI on basophils.J Allergy Clin Immunol，2004，113：297-302.
7. Djukanovi? R，Wilson SJ，Kraft M，et al.Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma.Am J Respir Crit Care Med，2004，170：583-593.
8. Soler M.Anti-IgE antibodies in the treatment of allergic diseases.Allergol Immunol Clin，2002，42：45-49． 8 Hayashi N，Tsukamoto Y，Sallas WM，et al.A mechanism-based binding model for the population pharmacokinetics and pharmacodynamics of omalizumab.Br J Clin Pharmacol，2007，63：548-561.
9. Dodig S，Richter D，Cepelak I.Anti-IgE therapy with omalizumab in asthma and allergic rhinitis.Acta Pharm，2005，55：123-138.
10. Saxon A，Kepley CL，Zhang K，et al."Accentuate the negative，eliminate the positive"：engineering allergy therapeutics to block allergic reactivity through negative signaling.J Allergy Clin Immunol，2008，121：320-325.
11. Kepley CL，Taghavi S，Mackay G，et al.Co-aggregation of FcgammaRII with FcepsilonRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes.J Biol Chem，2004，279：35139-35149.
12. Daëron M，Malbec O，Latour S，et al.Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors.J Clin Invest，1995，95：577-585.
13. Zhu D，Kepley CL，Zhang K，et al.A novel human immunoglobulin Fcγ–Fcε bifunctional fusion protein inhibits FcεRI-mediated degranulation.Nat med，2005，11：446-449.
14. Zhang K，Kepley CL，Terada T，et al.Inhibition of allergen-specific IgE reactivity by a human Ig Fcγ-Fcε bifunctional fusion protein.J Allergy Clin Immunol，2004，114：321-327.
15. Kepley CL，Zhang K，Zhu D，et al.Fc?RI-Fc?RII coaggregation inhibits IL-16 production from human Langerhans-like dendritic cells.Clin Immunol，2003，108：89-94.
16. Yamada T，Zhu D，Zhang K，et al.Inhibition of interleukin-4-induced class switch recombination by a human immunoglobulin Fc?-Fc? chimeric protein.J Biol Chem，2003，278：32818-32824.
17. Saxon A，Zhu D，Zhang K，et al.Genetically engineered negative signaling molecules in the immunomodulation of allergic diseases.Curr Opin Allergy Clin Immunol，2004，4：563-568.
18. Allen LC，Kepley CL，Saxon A，et al.Modifications to an Fcgamma-Fcvarepsilon fusion protein alter its effectiveness in the inhibition of FcvarepsilonRI-mediated functions.J Allergy Clin Immunol，2007，120：462-468.
19. Zhu D，Kepley CL，Zhang K，et al.A chimeric human-cat fusion protein blocks cat-induced allergy.Nat Med，2005，11：446-449.
20. Zhang K，Zhu D，Kepley CL，et al.Chimeric human fcγ-allergen fusion proteins in the prevention of allergy.Immunol Allergy Clin North Am，2007，27：93-103.
21. Terada T，Zhang K，Belperio J，et al.A chimeric human-cat Fcgamma-Fel d1 fusion protein inhibits systemic，pulmonary，and cutaneous allergic reactivity to intratracheal challenge in mice sensitized to Fel d1，the major cat allergen.Clin Immunol，2006，120：45-56.

Chinese Journal of Respiratory and Critical Care Medicine

Progress on Immunology and Biotherapy of Respiratory Allergic Disease

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