ObjectiveTo discuss the relationship between angiogenesis and the clinical pathological characteristics,
prognosis in primary gallbladder carcinoma (PGC ). MethodsThe specimens of 42 patients with PGC who underwent operation
during 1993 and 1996 were collected. The immunohistochemical staining was performed in these specimens through SABC manner.
Angiogenesis was represented by intratumor microvessel count (MVC ) and expression of vascular endothelial growth factor
(VEGF ).ResultsIn all the patients, the average MVC was 70.4±20.7, and the VEGF positive expression rate was 69.0%. The
mean MVC was 57.9±15.4 in the tumor of histograde Ⅰ and Ⅱ, and was 88.8±11.5 in another group of grade Ⅲ and Ⅳ
respectively. The mean MVC was 45.0±17.0 in the cases of Nevin stage Ⅰ, Ⅱ and Ⅲ, and was 77.2±16.0 in the other cases
of Nevin stage Ⅳ and Ⅴ. There were significant differences between two groups. VEGF expression positive rate was correlated
with grade and stage, in the patients with poordifferentiated grade and late stage the MVC was significant higher. The
expression of VEGF was markedly correlated with MVC. The 3year survival rate was significant lower in the group of high MVC
or VEGF positive expression. Conclusion Manifold VEGF secretion in PGC may increase the MVC value, and accelerate the tumor
advance and metastasis. Angiogenesis may be considered as an effective predictor to the prognosis of the primary gallbladder
carcinoma.
Citation：
YANG Yijun,LIU Jianmin,SHI Jingsen.. Clinical Significance of Angiogenesis in Primary Gallbladder Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(5): 345-347. doi:
Copy
Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
| 1. |
Hanahan D，Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis [J]. Cell，1996； 86（3）∶353.
|
| 2. |
Heimann R，Ferguson D，Powers C，et al. Angiogenesis as a predictor of longterm survival for patients with nodenegative breast cancer [J]. J Natl Cancer Inst，1996； 88（23）∶1764.
|
| 3. |
Pavlopoulos PM，Konstantinidou AE，Agapitos E，et al. A morphometric study of neovascularization in colorectal carcinoma [J]. Cancer， 1998； 83（10）∶2067.
|
| 4. |
杨毅军,石景森. 血管内皮生长因子与肿瘤血管生成 [J]. 中国普外基础与临床杂志, 2001; 8(3)∶205.
|
| 5. |
白涛,郭仁宣,王浩. 血管生成与胆囊癌发展和预后的关系 [J]. 中国普外基础与临床杂志, 2001; 8(2)∶101.
|
| 6. |
Samoto K，Ikezaki K，Ono M，et al. Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors [J]. Cancer Res，1995； 55（5）∶1189.
|
| 7. |
Okita S，Kondoh S，Shiraishi K，et al. Expression of vascular endothelial growth factor correlates with tumor progression in gallbladder cancer [J]. Int J Oncol，1998； 12（5）∶1013.
|
| 8. |
Benoist S，Panis Y，Fagniez PL，et al. Longterm results after curative resection for carcinoma of the gallbladder. French University Association for Surgical Research [J]. Am J Surg，1998； 175（2）∶118.
|
| 9. |
McNamara DA，Harmey JH，Walsh TN，et al. Significance of angiogenesis in cancer therapy [J]. Br J Surg，1998； 85（8）∶1044.
|
- 1. Hanahan D，Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis [J]. Cell，1996； 86（3）∶353.
- 2. Heimann R，Ferguson D，Powers C，et al. Angiogenesis as a predictor of longterm survival for patients with nodenegative breast cancer [J]. J Natl Cancer Inst，1996； 88（23）∶1764.
- 3. Pavlopoulos PM，Konstantinidou AE，Agapitos E，et al. A morphometric study of neovascularization in colorectal carcinoma [J]. Cancer， 1998； 83（10）∶2067.
- 4. 杨毅军,石景森. 血管内皮生长因子与肿瘤血管生成 [J]. 中国普外基础与临床杂志, 2001; 8(3)∶205.
- 5. 白涛,郭仁宣,王浩. 血管生成与胆囊癌发展和预后的关系 [J]. 中国普外基础与临床杂志, 2001; 8(2)∶101.
- 6. Samoto K，Ikezaki K，Ono M，et al. Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors [J]. Cancer Res，1995； 55（5）∶1189.
- 7. Okita S，Kondoh S，Shiraishi K，et al. Expression of vascular endothelial growth factor correlates with tumor progression in gallbladder cancer [J]. Int J Oncol，1998； 12（5）∶1013.
- 8. Benoist S，Panis Y，Fagniez PL，et al. Longterm results after curative resection for carcinoma of the gallbladder. French University Association for Surgical Research [J]. Am J Surg，1998； 175（2）∶118.
- 9. McNamara DA，Harmey JH，Walsh TN，et al. Significance of angiogenesis in cancer therapy [J]. Br J Surg，1998； 85（8）∶1044.
