Research Progression of Hepatic Sinusoidal Endothelial Cell_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

PAN Jiebin , JIAO Zuoyi , ZHANG Donghong , LIN Xiaoting ,  ZHANG Youcheng

Institute of Hepatopancreaticobiliary Surgery &;
Department of General Surgery， The Second Hospital of Lanzhou University， Lanzhou 730070， Gansu Province， China;

Corresponding author：

ZHANG Youcheng, Email: zhangychphd@yahoo.cn

Keywords：

Hepatic sinusoidal endothelial cell; Liver regeneration; Liver disease

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Objective 　To analyze and summarize the research progression of phenotypic markers of hepatic sinusoidal endothelial cell （HSEC） and its role in the development and progression of the liver diseases.
Methods 　Databases such as PubMed， Wanfang， CNKI， etc were retrieved for the latest articles on research advance in HSEC using “hepatic sinus endothelial cell”， “liver regeneration”， and “liver disease” as key words. All of the publications about studies on relation between HSEC and liver disease were reviewed and summarized.
Results 　HSEC with specific cytoarchitectures and phenotypic markers was initially received “the message of damage” in the process of liver regeneration， hepatic immunological tolerance， hepatic fibrosis， and liver damage. Additionally， HSEC as the first barrier not only enabled liver to be protected but also was regarded as the first alternation of liver damage. Therefore， HSEC played a great important role in the process of the onset and progression of the liver disease.
Conclusions 　The function of HSEC is complex. How do play a role and its the mechanism is unclarified， it is needed to be further studied.

Citation： PAN Jiebin,JIAO Zuoyi,ZHANG Donghong,LIN Xiaoting,ZHANG Youcheng,.. Research Progression of Hepatic Sinusoidal Endothelial Cell. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(5): 579-582. doi: Copy

1.	Burt AD， Le Bail B， Balabaud C， et al. Morphologic investigationof sinusoidal cells[J]. Semin Liver Dis， 1993， 13(1)：21-38.
2.	Vidal-Vanaclocha F， Rocha MA， Asumendi A， et al. Role of periportal and perivenous sinusoidal endothelial cells in hepatic homing of blood and metastatic cancer cells[J]. Semin Liver Dis， 1993， 13(1)：60-71.
3.	杨丽，江宇冰. 肝窦内皮细胞与肝窦毛细血管化研究进展[J]. 传染病信息， 2010， 23(3)：183-186.
4.	侯玉芳，贺福初，李继昌，等. 肝窦内皮细胞的分离纯化及鉴定方法[J]. 细胞与分子免疫学杂志， 2011， 27(9)：1033-1035.
5.	Oda M， Yokomori H， Han JY. Regulatory mechanisms of hepaticmicrocirculatory hemodynamics：hepatic arterial system[J]. Clin Hemorheol Microcirc， 2006， 34(1-2)：11-26.
6.	Cichoz-Lach H， Celiński K， Słomka M， et al. Pathophysiologyof portal hypertension[J]. J Physiol Pharmacol， 2008， 59(Suppl 2)：231-238.
7.	Ijaz S， Winslet MC， Seifalian AM. The effect of consecutively larger doses of L-arginine on hepatic microcirculation and tissue oxygenation in hepatic steatosis[J]. Microvasc Res， 2009， 78(2)：206-211.
8.	王宪波，刘平，唐志鹏. 虫草菌丝提取物对二甲基亚硝胺大鼠肝窦内皮细胞损伤和表型改变的影响[J]. 北京中医药大学学报， 2008， 31(7)：448-451.
9.	Garncarczyk A， Jurzak M， Gojniczek K. Characteristic of the endogenous peptides-endothelins and their role in the connective tissue fibrosis[J]. Wiad Lek， 2008， 61(4-6)：126-134.
10.	孟中良，张培建. 肝窦内皮细胞缺血再灌注损伤防治的研究进展[J]. 中国普通外科杂志， 2009， 18(9)：976-978.
11.	Harb R， Xie G， Lutzko C， et al. Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury[J]. Gastroenterology， 2009， 137(2)：704-712.
12.	Arimoto J， Ikura Y， Suekane T， et al. Expression of LYVE-1 in sinusoidal endothelium is reduced in chronically inflamed human livers[J]. J Gastroenterol， 2010， 45(3)：317-325.
13.	王泽，王磊，谢来峰，等. 大鼠肝窦内皮细胞的分离、鉴定及纯度、活性分析[J]. 河南科学， 2009， 27(8)：930-934.
14.	赵秀华，罗彬，罗盘，等. 小鼠肝脏窦状内皮细胞分离和培养的一种新方法[J]. 国际病理科学与临床杂志， 2012， 30(1)：1-7.
15.	闫蕾，赵彩彦. 肝脏——一个新的免疫器官[J]. 国际内科学杂志， 2009， 36(4)：206-210.
16.	杨晓凤. 肝窦内皮细胞及其影响肝纤维化的研究概况[J]. 中国民族民间医药， 2010， 19(8)：38， 43.
17.	徐胜元，何凡，陈知水. 肝窦内皮细胞在肝脏免疫耐受中的作用[J]. 现代免疫学， 2009， 29(1)：85-88.
18.	刘彪，傅童生，唐丽，等. 一种改良的小鼠肝窦内皮细胞的分离、纯化、培养及鉴定方法[J]. 细胞生物学杂志， 2009， 31(3)：437-442.
19.	张云霞，刘杞. 肝窦内皮细胞与免疫耐受[J]. 世界华人消化杂志， 2006， 14(28)：2776-2779.
20.	Bosch J. Vascular deterioration in cirrhosis：the big picture[J]. J Clin Gastroenterol， 2007， 41(Suppl 3)：S247-S253.
21.	Clozel M， Gray GA， Breu V， et al. The endothelin ETB receptormediates both vasodilation and vasoconstriction in vivo[J]. Biochem Biophys Res Commun， 1992， 186(2)：867-873.
22.	Rockey DC， Weisiger RA. Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver：implications for regulation of portal pressure and resistance[J]. Hepatology， 1996， 24(1)：233-240.
23.	Drixler TA， Vogten MJ， Gebbink MF， et al. Plasminogen mediatesliver regeneration and angiogenes si after experimental partial hepatectomy[J]. Br J Surg， 2003， 90(11)：690-698.
24.	Taniguchi E， Sakisaka S， Matsuo K， et al. Expression and role of vascular endothelial growth factor in liver regeneration after partial hepatectomy in rats[J]. J Histochem Cytochem， 2001， 49(1)：121-130.
25.	Sato T， El-Assal ON， Ono T， et al. Sinusoidal endothelial cell proliferation and expression of angiopoietin/Tie family in regenerating rat liver[J]. J Hepatol， 2001， 34(5)：690-698.
26.	Shimizu H， Miyazaki M， Wakabayashi Y， et al. Vascularendothelial growth factor secreted by replicating hepatocytes inducessinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in rats[J]. J Hepatol， 2001， 34(5)：683-689.
27.	Mochida S， Ishikawa K， Toshima K， et al. The mechanisms of hepatic sinusoidal endothelial cell regeneration：a possible communication system associated with vascular endothelial growth factor in liver cells[J]. J Gastroenterol Hepatol， 1998， 13 Suppl：S1-S5.
28.	Camussi G， Montrucchio G， Lupia E， et al. Angiogenesis inducedin vivo by hepatocyte growth factor is mediated by plateletactiv-ating factor synthesis from macrophages[J]. J Immunol， 1997， 158(3)：1302-1309.
29.	Lalor PF， Lai WK， Curbishley SM， et al. Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo[J]. World J Gastroenterol， 2006， 12(34)：5429-5439.
30.	Kraizer Y， Mawasi N， Seagal J， et al. Vascular endothelial growth factor and angiopoietin in liver regeneration[J]. BiochemBiophys Res Commun， 2001， 287(1)：209-215.
31.	Ross MA， Sander CM， Kleeb TB， et al. Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver[J]. Hepatology， 2001， 34(6)：1135-1148.
32.	方路，王开阳，黄长文. 二氧化碳气腹对大鼠肝窦内皮细胞的影响[J]. 广东医学， 2011， 32(10)：1243-1244.
33.	Copple BL， Banes A， Ganey PE， et al. Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure[J]. Toxicol Sci， 2002， 65(2)：309-318.

1. Burt AD， Le Bail B， Balabaud C， et al. Morphologic investigationof sinusoidal cells[J]. Semin Liver Dis， 1993， 13(1)：21-38.
2. Vidal-Vanaclocha F， Rocha MA， Asumendi A， et al. Role of periportal and perivenous sinusoidal endothelial cells in hepatic homing of blood and metastatic cancer cells[J]. Semin Liver Dis， 1993， 13(1)：60-71.
3. 杨丽，江宇冰. 肝窦内皮细胞与肝窦毛细血管化研究进展[J]. 传染病信息， 2010， 23(3)：183-186.
4. 侯玉芳，贺福初，李继昌，等. 肝窦内皮细胞的分离纯化及鉴定方法[J]. 细胞与分子免疫学杂志， 2011， 27(9)：1033-1035.
5. Oda M， Yokomori H， Han JY. Regulatory mechanisms of hepaticmicrocirculatory hemodynamics：hepatic arterial system[J]. Clin Hemorheol Microcirc， 2006， 34(1-2)：11-26.
6. Cichoz-Lach H， Celiński K， Słomka M， et al. Pathophysiologyof portal hypertension[J]. J Physiol Pharmacol， 2008， 59(Suppl 2)：231-238.
7. Ijaz S， Winslet MC， Seifalian AM. The effect of consecutively larger doses of L-arginine on hepatic microcirculation and tissue oxygenation in hepatic steatosis[J]. Microvasc Res， 2009， 78(2)：206-211.
8. 王宪波，刘平，唐志鹏. 虫草菌丝提取物对二甲基亚硝胺大鼠肝窦内皮细胞损伤和表型改变的影响[J]. 北京中医药大学学报， 2008， 31(7)：448-451.
9. Garncarczyk A， Jurzak M， Gojniczek K. Characteristic of the endogenous peptides-endothelins and their role in the connective tissue fibrosis[J]. Wiad Lek， 2008， 61(4-6)：126-134.
10. 孟中良，张培建. 肝窦内皮细胞缺血再灌注损伤防治的研究进展[J]. 中国普通外科杂志， 2009， 18(9)：976-978.
11. Harb R， Xie G， Lutzko C， et al. Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury[J]. Gastroenterology， 2009， 137(2)：704-712.
12. Arimoto J， Ikura Y， Suekane T， et al. Expression of LYVE-1 in sinusoidal endothelium is reduced in chronically inflamed human livers[J]. J Gastroenterol， 2010， 45(3)：317-325.
13. 王泽，王磊，谢来峰，等. 大鼠肝窦内皮细胞的分离、鉴定及纯度、活性分析[J]. 河南科学， 2009， 27(8)：930-934.
14. 赵秀华，罗彬，罗盘，等. 小鼠肝脏窦状内皮细胞分离和培养的一种新方法[J]. 国际病理科学与临床杂志， 2012， 30(1)：1-7.
15. 闫蕾，赵彩彦. 肝脏——一个新的免疫器官[J]. 国际内科学杂志， 2009， 36(4)：206-210.
16. 杨晓凤. 肝窦内皮细胞及其影响肝纤维化的研究概况[J]. 中国民族民间医药， 2010， 19(8)：38， 43.
17. 徐胜元，何凡，陈知水. 肝窦内皮细胞在肝脏免疫耐受中的作用[J]. 现代免疫学， 2009， 29(1)：85-88.
18. 刘彪，傅童生，唐丽，等. 一种改良的小鼠肝窦内皮细胞的分离、纯化、培养及鉴定方法[J]. 细胞生物学杂志， 2009， 31(3)：437-442.
19. 张云霞，刘杞. 肝窦内皮细胞与免疫耐受[J]. 世界华人消化杂志， 2006， 14(28)：2776-2779.
20. Bosch J. Vascular deterioration in cirrhosis：the big picture[J]. J Clin Gastroenterol， 2007， 41(Suppl 3)：S247-S253.
21. Clozel M， Gray GA， Breu V， et al. The endothelin ETB receptormediates both vasodilation and vasoconstriction in vivo[J]. Biochem Biophys Res Commun， 1992， 186(2)：867-873.
22. Rockey DC， Weisiger RA. Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver：implications for regulation of portal pressure and resistance[J]. Hepatology， 1996， 24(1)：233-240.
23. Drixler TA， Vogten MJ， Gebbink MF， et al. Plasminogen mediatesliver regeneration and angiogenes si after experimental partial hepatectomy[J]. Br J Surg， 2003， 90(11)：690-698.
24. Taniguchi E， Sakisaka S， Matsuo K， et al. Expression and role of vascular endothelial growth factor in liver regeneration after partial hepatectomy in rats[J]. J Histochem Cytochem， 2001， 49(1)：121-130.
25. Sato T， El-Assal ON， Ono T， et al. Sinusoidal endothelial cell proliferation and expression of angiopoietin/Tie family in regenerating rat liver[J]. J Hepatol， 2001， 34(5)：690-698.
26. Shimizu H， Miyazaki M， Wakabayashi Y， et al. Vascularendothelial growth factor secreted by replicating hepatocytes inducessinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in rats[J]. J Hepatol， 2001， 34(5)：683-689.
27. Mochida S， Ishikawa K， Toshima K， et al. The mechanisms of hepatic sinusoidal endothelial cell regeneration：a possible communication system associated with vascular endothelial growth factor in liver cells[J]. J Gastroenterol Hepatol， 1998， 13 Suppl：S1-S5.
28. Camussi G， Montrucchio G， Lupia E， et al. Angiogenesis inducedin vivo by hepatocyte growth factor is mediated by plateletactiv-ating factor synthesis from macrophages[J]. J Immunol， 1997， 158(3)：1302-1309.
29. Lalor PF， Lai WK， Curbishley SM， et al. Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo[J]. World J Gastroenterol， 2006， 12(34)：5429-5439.
30. Kraizer Y， Mawasi N， Seagal J， et al. Vascular endothelial growth factor and angiopoietin in liver regeneration[J]. BiochemBiophys Res Commun， 2001， 287(1)：209-215.
31. Ross MA， Sander CM， Kleeb TB， et al. Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver[J]. Hepatology， 2001， 34(6)：1135-1148.
32. 方路，王开阳，黄长文. 二氧化碳气腹对大鼠肝窦内皮细胞的影响[J]. 广东医学， 2011， 32(10)：1243-1244.
33. Copple BL， Banes A， Ganey PE， et al. Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure[J]. Toxicol Sci， 2002， 65(2)：309-318.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Progression of Hepatic Sinusoidal Endothelial Cell

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