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find Author "丁国文" 3 results
  • COX-2 Polymorphism and Susceptibility to Esophageal Cancer: A Meta-analysis

    Objective To investigate the relationship between cyclooxygenase-2 (COX-2) gene polymorphism and genetic susceptibility to esophageal cancer. Methods The PubMed and EMbase databases were searched from the date of their establishment to January 1st, 2011 to collect the case-control studies on COX-2 polymorphism and susceptibility to esophageal cancer. For the population genotype distributions of both esophagus cancer group and control group, their odds ratios (ORs) and 95% confidence intervals (CIs) were taken as the effect indexes, either the fixed or random effect model was applied to conducted Meta-analysis in homozygote comparison, dominant and recessive genetic models, and the publication bias was assessed then. All statistical analyses were conducted with Stata11.0 software. Results A total of five case-control studies were included. The results of meta-analyses showed for the COX-2-765Ggt;C polymorphism, the CC+GC genotype was associated with the risk of esophageal cancer in a dominant genetic model (CC+GC vs. GG: OR=1.806, 95% CI 1.050 to 3.106); for the COX-2-1195Ggt;A polymorphism, the AA genotype was associated with the risk of esophageal cancer in homozygote comparison and recessive genetic models, the AA+GA genotype was associated with the risk of esophageal cancer in a dominant genetic model. Conclusion It is suggested that COX-2 polymorphism may be associated with genetic susceptibility to esophageal cancer.

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  • Clinical application of Mimics software system to three-dimensional reconstruction to guide thoracoscopic anatomic pulmonary segmentectomy

    ObjectiveTo investigate the clinical effect of 3D computed tomography bronchial bronchography and angiography (3D-CTBA) and guidance of thoracoscopic anatomic pulmonary segmentectomy by Mimics software system. MethodsA retrospective analysis was performed on patients who underwent thoracoscopic segmentectomy in the Department of Thoracic Surgery of Affiliated People's Hospital of Jiangsu University from June 2020 to December 2022. The patients who underwent preoperative 3D-CTBA using Materiaise's interactive medical image control system (Mimics) were selected as an observation group, and the patients who did not receive 3D-CTBA were selected as a control group. The relevant clinical indicators were compared between the two groups. ResultsA total of 59 patients were included, including 29 males and 30 females, aged 25-79 years. There were 37 patients in the observation group, and 22 patients in the control group. The operation time (163.0±48.7 min vs. 188.8±43.0 min, P=0.044), intraoperative blood loss [10.0 (10.0, 20.0) mL vs. 20.0 (20.0, 35.0) mL, P<0.001], and preoperative puncture localization rate (5.4% vs. 31.8%, P=0.019) in the observation group were better than those in the control group. There was no statistically significant difference in the thoracic tube placement time, thoracic fluid drainage volume, number of intraoperative closure nail bin, postoperative hospital stay, or postoperative air leakage incidence (P>0.05) between the two groups. ConclusionFor patients who need to undergo anatomical pulmonary segmentectomy, using Mimics software to produce 3D-CTBA before surgery can help accurately identify pulmonary arteriovenous anatomy, reduce surgical time and intraoperative blood loss, help to determine the location of nodules and reduce invasive localization before surgery, and alleviate patients' pain, which is worthy of clinical promotion.

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  • 风湿性心脏病与非风湿性心脏病患者三尖瓣置换的病例对照研究

    目的分析三尖瓣置换患者的流行病学特征、治疗及随访情况,探讨提高三尖瓣置换疗效的策略。方法回顾性分析 2009 年 8 月至 2016 年 10 月 20 例在我院行三尖瓣置换患者的临床资料。男 4 例、女 16 例,年龄 31~73(54.4±2.2)岁。根据病因学分为风湿性心脏病组(14 例)及非风湿性心脏病组(6 例),比较两组患者术前情况、治疗方法、治疗结果及随访情况的差异。结果本组围手术期死亡 3 例,住院病死率 15.0%。死亡原因均为多器官功能衰竭。术后对 17 例出院患者进行了随访,随访率 100.0%,随访时间 1~84 个月,随访期间共有 2 例死亡。风湿性疾病组与非风湿性疾病组术前存在心房颤动/心房扑动心律(P=0.001)、术前有心脏手术史(P=0.017)、手术中是否进行主动脉阻断(P=0.032)差异有统计学意义。结论尽管风险较大,三尖瓣置换仍是针对器质性三尖瓣病变的有效手段,但需严格掌握手术指征及手术时机。风湿性三尖瓣疾病具有更多的危险因素,尤其是既往有左心瓣膜手术史继发三尖瓣关闭不全的患者。

    Release date:2018-03-28 03:22 Export PDF Favorites Scan
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