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find Author "代华" 3 results
  • 深部真菌感染的耐药机制研究进展

    【摘要】随着深部真菌感染日益增加及抗真菌药物的广泛应用,深部真菌耐药现象也日益突出。近十年以来,虽有较多新型抗真菌感染药物相继研发并应用于临床,但国内外已有较多对其耐药的病案报道。真菌面对唑类等强大的抗真菌药物也不断产生着严重的耐药性,并迅速使一些院内真菌感染陷入了无药可选的境地。因此,研究真菌的耐药机制并寻找新的抗真菌药物已成当务之急。现就按照抗真菌药物分类,对近年来国内外深部真菌感染的耐药机制的研究进展进行综述,以明确深部真菌耐药发生的诱因、机制,为指导临床合理使用抗真菌药物;尽可能减少深部真菌耐药的发生及研究新一代抗真菌药物提供参考。

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  • Comparative analysis of inpatient medical service in primary medical institutions in Chengdu

    Objective To provide basis to improve the ability of primary care services in Chengdu by comparatively analyzing inpatient medical service of primary medical institutions (community health service centers and township health centers). Methods From October to November 2016, the data of inpatient services in primary medical institutions in Chengdu, including 390 primary medical institutions in 22 districts (cities) and counties, were investigated by questionnaire. SPSS 19.0 was used for data collection and analysis, while the univariate logistic regression and multiple logistic regression were used to analyze the influencing factors. Results It was more common for rural primary medical institutions to carry out inpatient medical services than urban (96.18% vs. 53.84%). The coverage rate of insurance in urban areas was higher than rural areas (98.41% vs. 90.87%), while the rate of adopting clinical pathway of single disease was quite low both in urban areas (23.81%) and rural areas (18.25%). Primary medical institutions in urban areas launched more special projects of inpatient services than those in rural areas (14.29%–17.46% vs. 3.57%–7.54%). The total amount of inpatient medical services in 2015 in rural areas was larger than urban areas (529 611 vs. 103 912), the total number of inpatient services in rural was 5.09 times that in urban primary medical institutions, the average inpatient services in 2015 per one rural primary medical institution was 1.27 times that in urban, per 10 000 residents in rural areas consumed 3.01 times more inpatient medical services than those in urban areas in average, the median beds utilization efficiency in rural areas was better than in urban areas (74.47% vs. 22.47%); work intensity of inpatient medical service in rural areas was greater than in urban areas (234.57 vs. 81.74 cases per year per doctor). The number of inpatient services was positively related to population in service (when less than 100 000 residents), inpatient beds, the number of drugs, the number of medical staff. Conclusions For inpatient medical service, there are obvious differences between urban and rural areas in Chengdu. Therefore, above differences should be taken into full consideration in the allocation of resources in primary medical institutions. Thus more targeted management measures should be formulated.

    Release date:2017-08-22 11:25 Export PDF Favorites Scan
  • A Cross-sectional Study of the Prevalence and Risk Factors for Hypertension in Women from Chengdu Communities

    ObjectiveTo investigate the prevalence and risk factors for hypertensive women in Chengdu communities, as well as the urban-rural differences. MethodsCluster random sampling method was used. Cross-sectional data on questionnaire for physical examination and laboratory tests were collected from study of 1 202 women in urban and rural Chengdu between February and October 2010. ResultsThis study enrolled the total of 1 202 women aged from 35 to 70 in Chengdu communities, where 616 were from urban areas and 586 from rural areas. Of them, 402 had hypertension with an overall prevalence rate of 33.44% and with the standardized prevalence of 35.27%. The prevalence of hypertension in urban women (42.86%) was higher than that of rural women (23.55%); the difference was statistical (χ2=13.057, P<0.001). The prevalence of hypertension increased with the age increase. The highest cardiovascular risk factors coexisted with hypertensive women was high waist circumference (abdominal obesity), followed by triglyceride (33.33%), total cholesterol (TC) (33.08%), impaired glucose tolerance (38.86%), impaired fasting glucose (IFG) (24.38%), body mass index (16.67%), and high density lipoprotein cholesterol (0.75%). The urban hypertensive women had higher the ratio and average of high waist circumference, IFG and TC than thoes from rural areas with a statistically difference (P<0.05). ConclusionHypertension prevalence in women from rural areas is higher than that in women from urban areas. The urban hypertensive women has higher ratio of risk factors than thoes from rural areas.

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