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find Author "任清泉" 5 results
  • Influence of Different Surgical Procedure on Prognosis of Elderly Patients with Stage Ⅰ Non-small Cell Lung Cancer

    ObjectiveTo evaluate the influence of different surgical procedure on the prognosis of elderly patients with stage Ⅰ non-small cell lung cancer (NSCLC). MethodsWe retrospectively analyzed the clinical data of 100 patients elder than 70 years with NSCLC in our hospital between January 2012 and December 2013. There were 60 males and 40 females patients at age of 70-85 (76±12) years. The patients were divided into two groups including a standard lobectomy group (62 patients, receiving standard lobectomy) and a limited resection group (38 patients receiving limited resection). Regular following-up was carried out after the surgery. The correlation between the survival rate and the incidences of complications, the surgical procedure were analyzed. ResultsThe incidence of complications in the standard lobectomy group and the limited resection group was 35.5%(22/62)and 39.5%(15/38)respectively. The three year survival rate and the five year survival rate in the two groups were similar between the two groups(85.5% versus 54.8% and 78.9% versus 55.3%). There was no statistical difference between the two groups. Staging is an independent factor for prognosis. ConclusionLobectomy is still the main therapy method for elderly stageⅠNSCLC patients. But limited resection also appears to be a viable surgical treatment for patients with cardiopulmonary physiologic impairment.

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  • 闭合伤致膈肌破裂的诊断与治疗

    Release date:2016-08-30 06:01 Export PDF Favorites Scan
  • 自发性食管破裂的早期诊断与治疗

    目的 总结自发性食管破裂的早期诊断、治疗方法及临床疗效。 方法 2004 年1 月- 2006 年6 月,收治15 例自发性食管破裂男性患者。年龄38 ~ 56 岁,平均46 岁。发病至确诊时间为6 ~ 72 h,其中lt; 24 h 12 例。暴食后上腹受压憋气所致3 例,暴食后跌伤1 例,大量饮酒后呕吐所致11 例。破口位于食管中下段或下段,长4 ~ 12 cm。1 例发病后于外院行内支架治疗并发食管、气管瘘1 个月,入院确诊后放弃治疗。余14 例均手术治疗,其中行食管修补术8 例,食管切除、食管胃吻合术6 例。 结果 14 例术后顺利恢复,住院11 ~ 18 d。无手术死亡、吻合口瘘和其他并发症发生。2 例术后2 个月出现吻合口轻度狭窄(0.6 ~ 0.8 cm),仅进流食,经胃镜直视下行球囊扩张后缓解。14 例获随访,随访时间6 个月~ 2 年。无进食困难及哽咽不适。行上消化道碘化油造影示吻合口通畅,食管无扩张,消化功能良好。 结论 自发性食管破裂经早期诊断和手术治疗均易治愈,并发症少,预后满意。

    Release date:2016-09-01 09:17 Export PDF Favorites Scan
  • 外伤性支气管断裂的诊断与治疗

    Release date:2016-09-01 09:26 Export PDF Favorites Scan
  • Chinese herbal medicine Euphorbia esula extract induces apoptosis and inhibits the proliferation, migration and invasion of multidrug resistant gastric carcinoma cells

    This paper aims to study the effects of traditional Chinese medicine Euphorbia esula on multidrug resistant human gastric cancer cells in the cell proliferation, migration, invasion and apoptosis, and to study the apoptosis-inducing pathway. Different dilutions of Euphorbia esula extract were used to process human multidrug resistant gastric cancer SGC7901/ADR cells. Cell proliferation inhibition phenomenon was determined by MTT experiment. Nuclear morphological changes of apoptotic cells and apoptotic indexes were observed and determined by Hochest33528 staining followed with fluorescence microscope observing. Flow cytometry was used to detect cell apoptosis rate. Cell migration and invasion ability were observed and determined by Transwell method. Spectrophotometry was used to detect caspase-3 and caspase-9 enzyme activity. Western blotting was used to detect subcellular distribution of cytochrome c. The results showed that Euphorbia esula extract had obvious inhibition effect on proliferation of gastric cancer multidrug resistant SGC7901/ADR cells, which was time- and concentration-dependent. After processing multidrug resistant gastric cancer SGC7901/ADR cells with Euphorbia esula extract, the apoptotic index and apoptosis rate were significantly increased than those in the control group, which showed a time- and dose-dependent mode; but if a caspase inhibitor was added, apoptosis index was not obviously increased. Transwell method showed that migration and invasion ability of the Euphorbia esula extract-processed SGC7901/ADR cells dropped significantly. Spectrophotometry showed that in Euphorbia esula extract-processed SGC7901/ADR cells, caspase-3 and caspase-9 expression were increased, which had significant differences with the control group. Western blotting test showed that the distribution of cytochrome c decreased in mitochondria, while increased in the cytoplasm (i.e., cytochrome c escaped from mitochondria to the cytoplasm). In conclusion, Euphorbia esula extract could inhibit the proliferation, migration and invasion, and induce apoptosis in human gastric cancer multidrug resistant SGC7901/ADR cells; and cytochrome c, caspase-9 and caspase-3 might be involved in cell apoptosis induced by Euphorbia esula extract, suggesting endogenous or mitochondrial apoptotic pathway.

    Release date:2018-04-16 09:57 Export PDF Favorites Scan
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