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胸外科癌症患者围术期低蛋白血症分析

目的　探索胸外科癌症患者围术期发生低蛋白血症的处理方法。　方法　回顾性分析河北医科大学第四医院2010年3～5月经组织病理学确诊的20例癌症患者的临床资料，其中男9例，女11例；年龄60 （34～78）岁；食管癌14例，肺癌6例。检测患者行常规开放式手术前、后血清白蛋白水平、术后胸腔引流量和引流液中蛋白质含量，行经左胸食管癌切除术11例，经右胸食管癌切除术3例，肺叶切除术6例。　结果　20例患者术后24 h、48 h、72 h平均胸腔引流量分别为512.5 ml、294.0 ml和168.5 ml。行不同术式患者术后24 h胸腔引流量差异有统计学意义（P＜0.05）。20例患者术后24 h、48 h、72 h胸腔引流液中平均总蛋白质含量分别为29.9 g/L、27.2 g/L和25.9 g/L。术前和术后第1、3、5 d血清白蛋白含量分别为38.0 g/L、29.0 g/L、23.0 g/L 和25.8 g/L。患者术后第3 d低蛋白血症发生率最高［75.0% （15/20）］ 。　结论　胸外科常规开放式手术患者术后低蛋白血症的发生率较高，但白蛋白的补充时机尚需进一步探讨。

The Clinical Effects of Exogenous Glutamine on Sepsis Patients with Hypoalbuminemia

ObjectiveTo explore the clinical effects of exogenous glutamine on patients suffering from sepsis with hypoalbuminemia in emergency department. MethodsEighty-six patients with sepsis and hypoalbuminemia enrolled from January to November 2013 in the Emergency Department of our hospital were randomly divided into treatment group and control group. Forty-three patients in the control group were given conventional treatments, while the other 43 in the treatment group were treated with glutamine therapy based on the conventional treatments. The clinical efficacy of the two groups including inflammatory markers, albumin level, APACHEⅡ score and SAPSⅡ score, mortality, length of hospital stay were analyzed on day 7, 14, and 28 after being enrolled. A comprehensive analysis of the clinical effects in these two groups was performed. ResultsEighty-six cases were enrolled in this study. The mortality on day 14 and 28 in the treatment group was significantly lower than that in the control group (P<0.05). Inflammatory markers (WBC count, CRP concentration, and PCT concentration) in patients of the treatment group were gradually decreased, whereas serum albumin levels were gradually increased compared with the control group (P<0.05). The cure rate of patients in the treatment group was significantly higher than that in the control group, while the average length of stay was shorter than the control group (P<0.05) on day 28. ConclusionExogenous glutamine supplementation can improve patient cure rates and reduce hospital stays which has good clinical effects on patients with sepsis and hypoalbuminemia in emergency department.

肝硬化低蛋白血症并双下肢水肿皮肤破溃渗液护理一例

低蛋白血症患者全身麻醉术中排出腹水致复张性肺水肿一例

Multivariate analysis of hypoproteinemia after laparoscopic assisted radical gastrectomy forgastric cancer and its effect on recent clinical outcome

Objective To investigate the risk factors of hypoproteinemia after laparoscopic assisted radical gastrectomy for gastric cancer and its influence on recent clinical outcome. Methods Retrospective case-control study was carried out. Clinical data of 135 patients underwent laparoscopic assisted radical gastrectomy for gastric cancer admitted to the Department of General Surgery in the First Affiliated Hospital of Xi’an Jiaotong University Medical College from June 2016 to June 2021 were collected. Postoperative hypoproteinemia was defined as serum albumin <30 g/Lon postoperative day 1. Observation indications: ① the incidence of hypoproteinemia after laparoscopic assisted radical gastrectomy for gastric cancer; ② analysis of risk factors for postoperative hypoproteinemia; ③ influence of postoperative hypoproteinemia on recent clinical outcome. Results ① Among 135 patients, 56 patients developed hypoproteinemia after operation (hypoproteinemia group) with an incidence of 41.5%, 79 patients without hypoproteinemia (non- hypoproteinemia group). ② Univariate analysis of risk factors for postoperative hypoproteinemia showed that age, preoperative albumin level, preoperative plasma volume, preoperative leukocyte, preoperative hemoglobin level, maximum tumor diameter, net intake on operative day and operative time were related to the occurrence of postoperative hypoproteinemia (P<0.05). The results of multivariate analysis showed that: age ≥65 years [OR=6.320, 95%CI (2.340, 17.068), P＜0.001], preoperative albumin level <35 g/L [OR=5.951, 95%CI (1.815, 19.507), P=0.003], operative time ≥5 h [OR=3.171, 95%CI (1.164, 8.640), P=0.024], and net intake on operative day ≥3 000 mL [OR=5.153, 95%CI (1.616, 16.432), P=0.006] were risk factors for postoperative hypoproteinemia. ③ Within 30 days after operation, the incidence of non surgery related complications in the hypoproteinemia group and the non-hypoproteinemia group were 30.4% (17/56) and 13.9% (11/79), respectively, and the incidence of surgery related complications were 10.7% (6/56) and 1.3% (1/79), respectively, with statistically significant differences (P<0.05). Conclusions Age ≥65 years, preoperative albumin level <35 g/L, operative time ≥5 h and net intake on operative day ≥3 000 mL are risk factors for hypoproteinemia after laparoscopic assisted radical gastrectomy. For patients suffered from hypoproteinemia (albumin <30 g/L) after surgery, the incidences of both surgery-related complications and non-surgery-related complications increase.