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find Author "余云" 2 results
  • 乳腺肿块的细针穿刺细胞学诊断

    Release date:2016-08-29 03:26 Export PDF Favorites Scan
  • Effect of Urokinase on Severity Acute Pancreatitis with Renal Injury in Rat

    Objective To explore the effect of renal microcirculation following severity acute pancreatitis (SAP) on renal injury and to explore the protection effect of urokinase on them. Methods A total of 192 Wistar rats were randomized divided into normal control group, SAP group, and urokinase group, then rats of 3 groups were sub-divided into 2, 6, 12, and 24 hours group, each group enrolled 16 rats. Of the 16 rats in each subgroup, 8 rats underwent blood flow of renal test, other 8 rats were sacrificed to get blood samples and to perform histopathological examination. The rat models of SAP were established by retrograde injecting with 5% sodium taurocholate into the cholangiopancreatic duct. Radioactive biomicrosphere technique was used to measure the blood flow of renal, levels of plasma thromboxane B2(TXB2) and 6-keto-prostaglandin F1α (6-Keto-PGF1α) were tested by the TXB2 kit and 6-Keto-PGF1α kit, and histopa-thological changes of renal tissues were observed by using HE staining. Results Compared with normal control group at the same time point, the blood flow of renal were lower (P<0.05), activity ratio of TXB2 to 6-Keto-PGF1α were higher(P<0.01), and the histopathological injury were worse (P<0.01) in rats of SAP group and urokinase group. Compared with SAP group, the blood flow of renal at 2, 6, and 12 hours in urokinase group were higher (P<0.01), the activity ratios of TXB2 to 6-Keto-PGF1α were lower (P<0.01), and the histopathological injury were lighter (P<0.05) in all the 4 time points of urokinase group. Conclusions The renal microcirculation dysfunction and increase of activity ratio of TXB2 to 6-Keto-PGF1α may play an important role in renal injury following SAP in early stage. Urokinase can protect the renal from such injuries.

    Release date:2016-09-08 10:35 Export PDF Favorites Scan
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