【摘要】目的探讨乳腺癌仿根治术中保留肋间臂神经（ICBN）的临床意义。方法将184例Ⅰ～Ⅲ期乳腺癌患者随机均分为两组，实验组术中保留ICBN； 对照组术中均切除ICBN。并对两组患者术后进行随访观察。结果两组乳腺癌切除均行常规仿根治术，手术过程顺利，平均手术时间实验组为（140±10） min，对照组为（130±10） min，实验组92例术中有80例成功保留ICBN，且患侧上肢感觉障碍发生率为6.25%（5/80），对照组发生率为54.3%（50/92），两组比较差异有显著性意义（χ2=45.51，P＜0.01），经术后3个月～3年随访，上肢感觉障碍实验组5例中有2例1年后好转； 对照组50例中1年后好转6例，两组肿瘤均无局部复发。结论在乳腺癌仿根治术中保留ICBN可有效地防止患侧上肢感觉障碍的发生。
ObjectiveTo summarize the current situation and progress of sentinel lymph node biopsy (SLNB) in breast cancer. MethodsDomestic and foreign documents related SLNB in breast cancer in recent years were collected to summaize some problems about the definition, indications, biopsy techniques, improvement methods of the detection rate, the pathological examinations of sentinel lymph node (SLN), the types of metastasis, clinical applications of SLNB technology in breast cancer, and so on. ResultsThe indications of SLNB were expanding. The development of the tracer, imaging examination, and pathological detection technology contributed to the status assessment of SLN in breast cancer. The operation method of SLNB in breast cancer had no uniform standards yet. There were many arguments on whether SLNB can guide axillary lymph node dissection, and the detection rate and the false negative rate of it varied widely. ConclusionsSLNB technology has became an important method in the surgical therapy of breast cancer, but the operation still needs to be further standardized. The clinical application of SLNB also needs a lot of prospective multicenter randomized experiments for further demonstration.