ObjectiveTo review trauma-induced coagulopathy and use of tranexamic acid in patients with traumatic hemorrhage. MethodsThe relevant literatures about the definition and pathogenesis of trauma-induced coagulopathy, and the use of tranexamic acid in patients with traumatic hemorrhage were reviewed. ResultsTraumatic-induced coagulopathy was a coagulation disorder in the early stage after injury, which was associated with the anticoagu-lation and increasing activity of fibrinolysis. Tranexamic acid as an anti-fibrinolytic drug, it had a good result in clinical application, which could reduce the mortality due to bleeding in use within 3 h after injury, the effect was the best in use within 1 h after injury, but it had no benefit or even would increase the mortality due to hemorrhage in use >3 h after injury. There was no standardized dosage of tranexamic acid, but the volumes of blood loss and blood transfusion had no difference under the different dosages. However, high dosage or long-term use of tranexamic acid might increase the risk of the thrombosis or epilepsy. ConclusionEmergency traumatic patients face a series of death threats related trauma. Appropriate and timely hemostasis is important for prognosis. Early, short-term, and appropriate dosage of tranexamic acid could obviously reduce mortality and adverse events, but its timing and dosages need to be further optimized.
目的 探讨三孔法腹腔镜胆囊阑尾联合切除术的临床价值。 方法 对64例胆囊良性病变合并急、慢性阑尾炎患者实施三孔法胆囊阑尾腹腔镜联合切除的临床资料进行分析。结果 64例均获成功，手术时间40~80 min，术后3~5 d出院，无并发症发生。结论 三孔法腹腔镜胆囊阑尾联合切除术具有创伤小、痛苦少、恢复快、住院时间短等优点，治疗胆囊阑尾良性疾病安全可靠，并可有效降低医疗费用。