目的 介绍1例因外伤后耻骨缺损造成反复复发腹股沟疝的治疗经验。方法 回顾性分析该患者的诊治经过，总结治疗经验。结果 该患者在外院接受左侧腹股沟疝修补术（Lichtenstein法），术后1年左侧腹股沟疝复发，再于笔者所在医院先后接受两次手术治疗。第1次行开放的双侧腹膜前间隙无张力疝修补术，术后1年再次复发，复发原因可能是补片下界固定不可靠。第2次的术式与第1次相同，术后患者恢复良好，随访16个月无复发。结论 外伤后耻骨缺损是疝修补术后复发的主要原因，坚固有效的补片支撑点是防止再次复发的关键。
【Abstract】ObjectiveTo establish adriamycin (ADM) resistant pancreatic cancer cell line SW1990/ADM and to investigate its drug resistance mechanism.MethodsADM-resistant pancreatic cancer cell line SW1990/ADM was obtained by culture of pancreatic cancer cell line SW1990 in vitro with intermittently increasing the concentration of ADM in the culture medium for ten months. After two months of drug free culture, its biological characteristics, drug sensitivity as well as the expression and function of multidrug resistant gene 1 (mdr1) were detected, respectively. ResultsCompared with the parental cell line, SW1990/ADM showed great changes in biological characteristics and developed a cross resistance to various chemotherapy drugs. The drug resistance indexes of cell line SW1990/ADM to ADM, mitomycin, fluorouracil and gemcitabine were 49.60, 7.25, 3.80 and 1.25, respectively. The level of mdr1 mRNA expression in cell line SW1990/ADM was much higher than that of the parental cell line（P＜0.01). ConclusionWe have established adriamycin resistant pancreatic cancer cell line SW1990/ADM with multidrug resistance phenotype, its multidrug resistance is positively relevant to the expression of mdr1.