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find Author "刘潇潇" 4 results
  • 噬血细胞综合征的临床研究进展

    噬血细胞综合征是由淋巴细胞、单核细胞和吞噬细胞系统异常激活、增殖所引起,由此导致的高细胞因子血症及继起的过度炎症反应,以致骨髓或者淋巴组织、器官中出现异常增多的组织细胞,并伴有吞噬自身血细胞行为为特征的综合征。其病因多样、临床表现复杂,如不及时治疗,患者可很快死于感染及多器官衰竭。现将近年来对噬血细胞综合征的临床研究进行综述。

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  • 系统性红斑狼疮患者使用免疫抑制剂后卵巢贮备功能的临床评估

    目的研究抗苗勒管激素(AMH)与系统性红斑狼疮(SLE)女性患者使用免疫抑制剂的关系,评估SLE患者卵巢贮备功能。 方法选取2009年1月-2013年12月72例年龄在18~40岁,符合美国风湿病学会诊断标准的初诊SLE女性患者,使用酶联免疫吸附测定法对患者用药前后血清中AMH进行检测,选取同期20例同年龄段健康女性作为正常对照。比较使用环磷酰胺(CTX)患者(A组,n=41)与未使用CTX患者(B组,n=31)血清AMH的差异,了解AMH水平与CTX累积剂量及年龄之间的关系。 结果72例SLE患者使用免疫抑制剂后血清中AMH水平[(2.39±1.12)ng/mL]较使用前[(3.12±1.38)ng/mL]及正常对照组[(2.95±0.86)ng/mL]低,差异均有统计学意义(P<0.05)。治疗后A组患者血清中AMH水平[(2.24±1.23)ng/mL]低于治疗前[(2.97±1.31)ng/mL],且低于B组患者血清中AMH水平[(2.92±0.82)ng/mL],差异有统计学意义(P<0.05);B组治疗前差异无统计学意义(P>0.05)。AMH水平与使用CTX累积剂量及年龄呈负相关(P<0.05)。 结论AMH可以作为评价SLE女性患者在使用CTX后造成卵巢损伤的一个指标。

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  • Relevances of serum prolactin level to clinical symptoms and disease activity of systemic lupus erythematosis

    Objective To explore the relevances of serum prolactin level to clinical symptoms and disease activities of systemic lupus erythematosis (SLE). Methods From December 2008 to December 2014, 63 female patients who met the American Rheumatism Society diagnostic criteria of SLE in the First People’s Hospital of Chengdu were collected as the SLE group, and other 20 healthy females were collected as the control group. The serum prolactin level was determined by immunofluorescence, and the disease activity of SLE was assessed by SLE Disease Activity Index (SLEDAI). The relevances of serum prolactin level to clinical symptoms and disease activity of SLE patients were analyzed. Results The mean serum prolactin level was (22.35±14.86) ng/mL in the SLE group and (15.30±8.54) ng/mL in the control group, respectively; the difference was statistically significant (P<0.05). In the 63 SLE patients, 15 (23.8%) had higher serum prolactin level compared with the normal ones. According to the SLEDAI score, the SLE patients were divided into stable group (25 patients), mild activity group (21 patients), moderate activity group (10 patients), and severe activity group (7 patients); and their serum prolactin levels were (20.43±11.23), (22.50±13.54), (27.97±21.20), and (33.91±18.18) ng/mL, respectively; the differences were not statistically significant (P>0.05). There were statistically significant differences (P<0.05) between the SLE patients with hyperprolactinemia and the ones with normal serum prolactin level in a number of clinical symptoms such as serositis, kidney damage,hematological system damage, and hypocomplementemia, but the serum prolactin level was not significantly correlated with the SLEDAI (rs=0.217, P=0.088). Conclusions Less hyperprolactinemia is found in SLE patients. Serum prolactin level is correlated with multiple clinical symptoms and laboratory indexes but not related to disease activity in SLE patients.

    Release date:2017-12-25 06:02 Export PDF Favorites Scan
  • 双磷酸盐联合甲氨喋呤治疗绝经后类风湿关节炎患者疗效观察

    目的:评价双磷酸盐联合甲氨喋呤治疗绝经后类风湿关节炎患者疗效,分析治疗方法对类风湿关节炎活动度指标的影响。方法:选择2005~2007年我院住院及门诊的活动期类风湿关节炎患者75例,随机双盲分为2组,其中甲氨喋呤组45例,甲氨喋呤+双磷酸盐组30例。检测两组使用药物前后患者疾病活动性指标及血清中类风湿关节炎活动度相关指标,评价甲氨喋呤+双磷酸盐治疗方法的疗效。结果:甲氨喋呤+双磷酸盐治疗组可以提高骨密度,治疗后两组观察指标比较,甲氨喋呤+双磷酸盐组疾病活动度指标改善明显好于单用甲氨喋呤组。结论:双磷酸盐能有效防止骨丢失,帮助类风湿关节炎病情缓解。

    Release date:2016-09-08 10:02 Export PDF Favorites Scan
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