Objective To systematically review literature on the influencing factors related to adolescent sub-health problems. Methods We electronically searched the following four databases including CBM, VIP, CNKI and WanFang Data to collect Chinese literature on adolescent sub-health status and problems in China published before May 2012. Two reviewers independently screened literature, extracted data, and cross checked records. Then qualitative analysis was applied. Results According to the inclusion and exclusion criteria, 41 cross-sectional studies were included. The results of qualitative analysis showed that the influencing factors of adolescent sub-health could be classified into four categories including social factors, family factors, school factors, and interpersonal relationships. The main ones were social support, employment pressure, family economic conditions, learning burden, unhealthy habits, etc. Conclusions There are many influencing factors of adolescent sub-health with interaction. Due to the limitation of the included studies, more prospective cohort studies are needed to provide high quality evidence.
An increasing number of health system researchers use systematic review to synthesize research evidence to inform the development of health policies at global and national levels. However, there are methodological challenges facing the health system research in undertaking systematic reviews of health policy literatures. This paper explored the constraints and promise of systematic review as a tool for evidence-based health system research in developing countries. It introduced the systematic review method and its evolution in health research over the past decades. The paper then discussed the definition of health system research, as system science, and contrasted its features/characteristics to those of medical research. It discussed and analyzed if the systematic review could be an effective tool for evidence-based health system research, particularly in developing countries. The paper concludes that the systematic review may be a very useful tool that can be used for evidence-based health system research to address specific policy issues; however, research on some health system/policy issues may not be appropriate to use the systematic review at all.
ObjectiveTo analyze research status of influencing factors related to sun-protection problems in children and adolescents, and systematically review the influencing factors. MethodsWe electronically searched the following databases including The Cochrane Library, PubMed, Web of Knowledge, Ovid, EBSCO, EMbase, CBM, CNKI, VIP and WanFang Data to collect cross-sectional studies on sun-protection problems in children and adolescents up to December 2012. The criteria for cross-sectional studies recommended by AHQR was applied in the assessment of included studies. Then, qualitative analysis methods were used to systematically summarize information and results of the included studies. ResultsA total of 10 studies were included. The results showed that, the influencing factors of sun-protection behaviour in children and adolescents included gender, age, skin colour, eye colour, the mass media information, school health education, etc., of which, researches on gender, grade, light skin, eye colour were relatively more. ConclusionAt present, there are many studies about influencing factors related to sun-protection problems in children and adolescents while the target influencing factors differ in regions.
ObjectiveTo systematically review the model and mechanism, efficacy and its influencing factors of the promotion and application of appropriate health technology in China. MethodsSuch database as VIP, CNKI, CBM and WanFang Data were electronically searched to collect studies on the promotion and application of appropriate health technology in China published from the establishment dates to January 2013. According to the inclusion and exclusion criteria, two reviewers independently screened literature, extracted and cross-checked data, and assessed quality. Qualitative synthesis method was used to systematically summarize the included studies. ResultsA total of 73 studies were finally included. Targeted populations included primary medical staff and personnel who provided or developed appropriate health technologies, medical institutions and their managers, as well as patients who received service or treatment of appropriate health technology. The promotion of appropriate health technologies mainly contained five fields: Chinese medicine, biomedicine, family planning services, maternal and child health, and community health services. The government-leading model had been widely applied currently, besides, there were other four models: government-guidance, government-driven, market-leading and a third sector-leading models. Factors related to project funding, organization and management, technology holders, the supply and demand parties in technical services and technology itself might affect the application of appropriate health technology. Among all evaluation studies, the number of needs assessment was less, the contents of process evaluation were one-sided and the effect evaluation was mainly cross-sectional studies. ConclusionThis study shows that sustainable development of appropriate health technology promotion model need to fully consider market demand and people's needs, on the basis of using government-leading or introducing a third sector-leading model. Corresponding measures should be taken according to the influencing factors of promotion and application of appropriate health technology. It is necessary to conduct high quality evaluation studies in future and comprehensively evaluate the efficacy of the promotion and application of appropriate health technology.
Objective To summarize the donor factors and experimental factors that affect adipogenic differentiation of adipose derived stem cells, so as to provide reference for adipogenic differentiation of adipose derived stem cells. Methods The related research literature about donor factors and experimental factors affecting adipogenic differentiation of adipose derived stem cells in recent years was extensively reviewed and summarized. Results There are a lot of donor factors and experimental factors affecting adipogenic differentiation of adipose derived stem cells, but some of the factors are still controversial, such as donor age, health status, adipose tissue of different parts, and so on. These factors need to be further studied. Conclusion The donor factors and experimental factors that affect adipogenic differentiation of adipose derived stem cells should be deeply studied and the controversial issues should be clarified to lay a solid foundation for the application of adipose derived stem cells in adipose tissue engineering.
ObjectiveTo investigate the role and mechanism of S100A8/A9 in rat model of chronic obstructive pulmonary disease (COPD). Methods Twelve Wistar rats were randomly divided into a normal control group and a COPD group. The COPD model was established by exposing the rats to cigarette smoke and injected lipopolysaccharide (LPS) in bronchus for 1 month. The pathological changes of the lung tissue were observed under light microscope, and the emphysema indexes of pulmonary mean linear intercept (MLI), mean alveolar numbers (MAN) and pulmonary alveolar area (PAA) were analyzed by image analysis system. The concentrations of S100A8/A9 in serum and bronchoalveolar lavage fluid (BALF) were measured by enzyme linked immunosorbent assay. The mRNA expression levels of S100A8, S100A9, Toll-like receptor-4 (TLR4) and myeloid differentiation factor 88 (MyD88) of lung tissues were measured by real time polymerase chain reaction. The protein expressions of S100A8/A9, TLR4 and MyD88 of lung tissues were detected by immunohistochemistry. Results After cigarette smoking and LPS injection for 1 month, the rat lung tissue appeared in accordance with the typical pathological changes of COPD. The MLI, MAN and PAA had obvious difference compared with the normal control group (P<0.05). The concentrations of S100A8/A9 protein in BALF and serum of the COPD group were obviously higher than those of the normal control group (P<0.05). The levels of S100A8, S100A9, TLR4 and MyD88 mRNA of lung tissues in the COPD group were obviously higher than those in the normal control group (P<0.05), and the expression levels of S100A8 and S100A9 mRNA were positively correlated with the expression levels of TLR4 and MyD88 mRNA respectively (P<0.05). The levels of S100A8/A9, TLR4 and MyD88 protein of lung tissues in COPD group were obviously higher than those in normal control group (P<0.05), and the levels of S100A8/A9 protein were positively correlated with the levels of MyD88 and TLR4 protein (P<0.05). Conclusions As a new inflammatory mediator, S100A8/A9 may be involved in the occurrence and development of COPD. By up-regulating the expression of TLR4 and MyD88, the classical TLR4-MyD88 inflammatory pathway is activated, thus promotes the occurrence and development of COPD.
ObjectiveTo systematically review the relationship between polycyclic aromatic hydrocarbons (PAHs) and emotion and behaviors in children and adolescents. MethodsThe PubMed, EBSCO, Web of Science, CBM, VIP, WanFang Data, OVFT, Proquest Psychological database and CNKI databases were electronically searched to collect studies on the relationship between PAHs and emotion and behaviors in children and adolescents from inception to October 20, 2022. Two reviewers independently screened the literature, extracted data and assessed the risk of bias of the included studies. A qualitative systematic review was then performed. ResultsA total of six cohort studies were included, five studies involving maternal exposure during pregnancy, found that maternal exposure to PAHs during pregnancy was associated with an increase in childhood anxiety/depression syndrome, attention problems, social withdrawal, social competence, social problems, orientation/regulation, withdrawal behaviors, and autism-related behaviors. Another study of exposure in school-age children found that PAHs exposure was associated with poorer attention performance in school. Results of other emotional behaviors were inconsistent, or no association was found. ConclusionCurrent evidence shows that PAHs have certain effects on emotional behaviors of children and adolescents. Due to the limited quality and quantity of the included studies, more high-quality cohort studies are required to verify above conclusion.
ObjectiveTo systematically review the influence of childhood psychosocial stress on pubertal emotional and behavioral problems. MethodsThe PubMed, OVID, EBSCO, Web of Science, CBM, VIP, WanFang Data and CNKI databases were electronically searched to collect studies on the relationship between childhood psychosocial stress and pubertal emotional and behavioral problems from inception to February 29, 2024. Two reviewers independently screened the literature, extracted data and assessed the risk of bias in the included studies. Qualitative methods were then used to analyze the data. ResultsA total of 41 cohort studies were included. And outcomes in 19 studies involved pubertal emotional problems, 26 studies involved behavioral problems, and 7 studies involved overall problems. The results showed that depression (14/19) and anxiety (8/19) were the most commonly reported emotional behaviors. Most studies (17/19) showed that childhood psychological stress had a positive predictive effect on pubertal emotional problems. Behavioral problems involve many outcomes, including smoking, drinking, illegal substance use, self-injurious behavior, suicide, externalizing behavior, criminal behavior, bullying behavior, sexual behavior, mobile phone dependence, etc. However, few studies are on the same behaviors, and the relationship between childhood psychosocial stress and behavioral problems was unclear. ConclusionChildhood psychosocial stress may have a positive predictive effect on depression and anxiety. The association between childhood psychosocial stress and pubertal behavioral problems and other emotional problems remains to be determined by more studies.
Objective To systematically analyze the factors influencing the left-behind children’s mental health. Methods After the search term and strategy were confirmed by researchers, four Chinese databases including Chinese Biological Medical Literature Database (CBM), Chinese Science and Technology Periodical Database (VIP), China National Knowledge Infrastructure (CNKI) and WanFang Database (WF) were searched to collect papers, published before March 2011, on relevant factors influencing mental health of left-behind children in China. Then two reviewers independently screened, extracted and cross-checked the data, and the disagreements were resolved by discussion or by consulting a third reviewer. Qualitative synthesis method was used to analyze the study results. Results Of the total 3 252 records, 49 studies were included. The results of qualitative analysis showed that factors influencing left-behind children’s mental health could be classified into four categories including social factors, family factors, school factors and personal factors. Of the nearly 30 kinds of specific factors, the main ones were gender, age, parent-child relationship, social support, personality and characteristics, and outgoing condition of parents, etc. Conclusion Current research results indicate that many factors have influences on mental health of left-behind children, but the research quality is not high with low argument efficiency. There are still controversies on several factors’ impact. Longitudinal studies with rigorous design are needed to analyze the impact of different factors on the left-behind children’s mental health and to summarize the interaction between various factors, so as to provide scientific evidence for developing practical and effective intervention measures.