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find Author "刘鹤南" 3 results
  • 肾素-血管紧张素系统阻滞剂预防早产儿视网膜病变研究

    血管紧张素Ⅱ(Ang Ⅱ)是肾素血管紧张素系统(RAS)的主要效应产物和多种器官有效的生长因子。在早产儿视网膜病变(ROP)等缺血性视网膜病变中,RAS上调,视网膜RAS被激活,刺激具有促微血管渗漏、周细胞迁移、新生血管生成和纤维化功能的血管内皮生长因子(VEGF)等上调。对RAS的阻滞主要通过血管紧张素转换酶抑制剂和血管紧张素Ⅱ受体拮抗剂来实现。RAS阻滞剂在ROP的发生发展过程中可能具有防止和减弱病理性血管生成的作用。对RAS的阻断有望成为ROP的治疗途径。

    Release date:2016-09-02 05:41 Export PDF Favorites Scan
  • Epigenetics of diabetic retinopathy

    Epigenetic mechanisms influence gene expression and function without modification of the base sequence of DNA and may generateagenetic phenotype. Epigenetic modifications include DNA methylation, histone modifications, and deployment of noncoding RNA. There is growing evidence that epigenetic mechanisms could playacrucial role in the development of diabetic retinopathy (DR). Molecular biological methods which could maintain mitochondrial homeostasis through the regulation of epigenetic mechanisms may prevent the development of DR. Epigenetic-related treatment modalities will become the new direction of targeted therapy for DR.

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  • Intravitreal bevacizumab as a preoperative adjunct to vitrectomy for prevention of postoperative vitreous hemorrhage in proliferative diabetic retinopathy: a meta-analysis

    Objective To evaluate the efficacy and safety of intravitreal bevacizumab (IVB) as a preoperative adjunct to vitrectomy for prevention of postoperative vitreous hemorrhage (VH) in proliferative diabetic retinopathy (PDR) patients.Methods This was a meta analysis of randomized controlled trials (RCT). A computerized search was conducted in the Medline, Embase, Cochrane Library, Chinese Biomedical Database and Chinese Journal Full text Database combined with manually searching of bibliographies of pertinent articles, journals and literature reference proceedings. RCT on IVB as a preoperative adjunct to vitrectomy for prevention of postoperative VH in PDR were selected according to inclusion and exclusion criteria. After the data extraction, methodological quality assessment of RCT that were included using the Jadad scale. The outcome measures included the incidence of postoperative VH, postoperative best corrected visual acuity (BCVA), the incidence of postoperative retinal reattachment and postoperative complications. The statistical analysis was performed by Stata/SE 11.2. The weighted mean difference (WMD) with 95% confidence interval (CI) was calculated for continuous variable, and odds ratio (OR) with 95% CI for dichotomous variable. Results In total, seven RCT that fulfilled the eligibility criteria were included in the metaanalysis involving 170 patients in IVB group and 161 patients in control group. According to the Jadad scale, one RCT scored 5 points, one RCT scored 3 points and the other 5 RCT scored 1 point. The results suggested that IVB group achieved lower incidence of postoperative VH than control group both within four weeks after surgery (OR=3.28, 95% CI: 1.58-6.82,P=0.00), and over four weeks after surgery (OR=2.51, 95% CI1.21-5.22,P=0.01). There was no significant differences in incidence of postoperative VH between IVB and control group either at postoperative 3 months (OR=2.52, 95% CI: 0.74-8.57,P=0.14), or at postoperative 6 months (OR=3.26, 95% CI: 0.50-21.45,P=0.22). The results suggested that IVB group achieved better postoperative BCVA than control group (WM1=0.29, 95% CI: 0.13-0.44,P=0.00), but no significant differences were found between IVB and control group on the incidence of postoperative retinal reattachment (OR=0.39, 95% CI:0.10ndash;1.59,P=0.19), postoperative retinal re-detachment (OR=2.36, 95% CI: 0.74- 7.56, P=0.15) and postoperative neovascular glaucoma (OR=1.47, 95% CI: 0.28ndash;7.71,P=0.65). Conclusions IVB as a preoperative adjunct to vitrectomy could prevent postoperative VH in PDR effectively, and be relatively safe. However, a high-quality, multicenter, large sample, long-term RCT is warranted to be further investigated.

    Release date:2016-09-02 05:25 Export PDF Favorites Scan
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