Objective To compare and evaluate the effectiveness and safety of irinotecan (IRI) versus oxaplatin (OXA), in combination with 5-FU/LV for patients with advanced colorectal cancer. Methods The literature search, study selection and assessment, data collection and analysis were undertaken by two reviewers according to the Cochrane Handbook for Systematic Reviews of Interventions. Randomised controlled trials (RCTs) or quasi-RCTs comparing IRI versus OXA, in combination with 5-FU/LV in the treatment of advanced colorectal cancer were collected. Results Seven studies involving 2107 patients were included. The OXA/5-FU/LV regimen was superior or at least equal to the IRI/5-FU/LV regimen in prolonging overall survival and time to progression. The OXA/5-FU/LV regimen showed a higher response rate and was associated with lower toxicities. Conclusion Compared with IRI, OXA is more appropriate for the treatment of advanced colorectal cancer when combined with 5-FU/LV.
【Abstract】Objective To analyze the function of BAG3 in antiapoptosis and chemotherapy resistance induction process of pancreatic cancer.Methods The expressions of BAG-3 in pancreatic cancerous tissues of patients with chemotherapy and those without chemotherapy before resection were determined by immunohistochemistry. The expression difference of BAG-3 protein 18 hours after cultured with chemotherapy drugs (concentration of drugs: 5-FU 50 μg/ml, MMC 0.5 μg/ml, EADM 1.5 μg/ml) of 3 pancreatic cancer cell lines （MIACaPa-2, PANC-1, SW1990） was measured through Western blotting method.Results The median positive rate of pancreatic cancer tissue from patients accepted chemotherapy before resection was higher than those not accepted chemotherapy, but there wasn’t significant difference. Eighteen hours after cultured with drugs, the level of BAG-3 of this three cell lines had significant increased compared with control group (P＜0.05). Conclusion Chemotherapy induces elevation of BAG-3 expression of pancreatic cancer. The upregulate of BAG-3 may associate with the chemotherapy resistance induced by drugs.
Objective To review the recent studies on the multidrug resistance of breast cancer. Methods The literatures of recent years on the studies of multidrug resistance, multidrug resistance protein and breast cancer resistance protein were reviewed. Results Multidrug resistance resulted from multiple factors. How to identify the sensibility of chemotherapy drugs and select individual therapeutic regime early were important to improve the survival rate and life quality of breast cancer patients. Conclusion These studies on multidrug resistance of breast cancer are helpful to predicting the effect and outcome of chemotherapy and overcoming the barrier of drug resistance.
Objective To evaluate treatment of the bleeding and prolapse of hemorrhoids by copper ion electrochemistry.Methods All patients suffered from the bleeding and prolapse of internal hemorrhoids or mixed hemorrhoids were included in this study. There were 202 patients in trial group （79 patients with internal hemorrhoids，123 patients with mixed hemorrhoids）. Control group contained 171 cases （64 patients with internal hemorrhoids，107 patients with mixed hemorrhoids）. There were 56 patients with prolapse of inner hemorrhoids or mixed hemorrhoids. Copper ion electrochemistry was performed in trial group. Suppository was used in control group. After the rectum was sterilized, the copper needle was inserted into the hemorrhoid with the depth about 8-15 mm. Then we continued the therapy for 4 minutes and 40 seconds. Other hemorrhoids were treated in the same way. Results The cure rate in trial group with hemorrhoidal bleeding was 98.0%,special virtual rate was 1.50%，virtual rate was 0.5%, inefficiency rate was 0 (U=44.6，Plt;0.001). The cure rate in control group was 11.1%，special virtual rate was 24.6%，virtual rate was 28.1%，inefficiency rate was 36.3%. The cure rate of prolapse group was 48.2%，special virtual rate was 33.9%，virtual rate was 17.9%. The patients didn’t feel uncomfortable and recovered 4 hours later after operation. Conclusion This therapy was safe, effective and simple.
Objective To evaluate the effect of the allied chemotherapy with 5-Fu、leucovorin (CF) and levamisole (LV) after resection of colorectal cancer. Methods 242 cases were divided randomly into three groups. 80 cases (group Ⅰ) were treated with 5-Fu and CF. 80 cases(groupⅡ) were treated with 5-Fu and LV. 82 cases (group Ⅲ) were treated with 5-Fu、CF and LV. Results The recurrence rates of group Ⅲ was 12.20%, which was significantly lower than that of group Ⅰ (26.25%) and group Ⅱ(27.50%). (P＜0.05). The 5-year survival rates in group Ⅰ, group Ⅱ and group Ⅲ were 37.50%, 35.00% and 58.54%, respectively, the highest one was in Group Ⅲ (P＜0.01). Conclusion The allied chemotherapy with 5-Fu、CF and LV is an effective therapy for petients of colorectal cancer after surgery, which can significantly decrease the recurrence and improve the 5-year survival rate.
Objective To evaluate short-term effects of percutaneous microwave coagulation therapy（PMCT） combined with chemotherapy in patients with advanced non-small cell lung cancer（NSCLC）.Methods Eighty cases with advanced NSCLC were randomly assigned to underwent chemotherapy plus PMCT(PMCT group，n=40) or single chemotherapy(chemotherapy group，n=40).The chemotherapeutics regimen was Taxotere plus Cisplatin.The preliminary results and quality of life score of two groups were compared.Results In PMCT group and chemotherapy group，the 3-month relieve rate was 52.5% and 32.5%，and the half-year survival rate was 87.5% and 62.5%，respectively.The differences between the two groups were both significant(Plt;0.05).The quality of life score in PMCT group was significantly higher than that in chemotherapy group (Plt;0.05).Conclusion PMCT combined with chemotherapy is effective and safe in the treatment of advanced NSCLC.
目的 探讨妇科化学治疗（化疗）患者自我管理效能感与焦虑抑郁的关系。 方法 2011年10月－2012年1月采用中文版癌症自我管理效能感量表和医院焦虑抑郁量表对110例妇科化疗患者进行问卷调查。 结果 共收回有效问卷106份。33例（31.70%） 患者焦虑阳性，43例（41.30%） 抑郁阳性，35例（33.70%） 焦虑抑郁均为阳性；自我管理效能感得分为（86.31 ± 27.06）分，并与焦虑呈负相关（r = −0.793，P = 0.000），与抑郁呈负相关（r = −0.753，P = 0.000）。 结论 妇科化疗患者自我管理效能感与焦虑抑郁密切相关，在以后的护理工作中应该重视妇科肿瘤患者自我管理项目的构建，提高患者的自我效能，从而改善其心理状况。