【摘要】 目的 探讨脱细胞真皮基质材料应用于整形美容领域的可能性。 方法 2008年11月-2009年8月，对脱细胞真皮基质进行溶血试验、皮下埋植和肌肉埋植试验，分别于术后1、2、4周取样并评价其与血液接触反应，以及在体内的降解情况，同时与对照材料相比较，对脱细胞真皮基质的安全性和使用功能性进行初步的研究。 结果 脱细胞真皮基质具有良好的血液相容性和组织相容性，不引起机体的排斥反应;不同厚度的真皮基质具有不同的降解率，可根据使用需要进行叠加。 结论 脱细胞真皮基质可作为生物组织补片，具有应用于整形美容领域和组织修复的潜力。【Abstract】 Objective To study the potential application of xenograft acellular dermal sheets in plastic surgery field. Methods The xenograft acellular dermal sheets were estimated by hemolytic test, subcutaneous and muscular embedding animal tests.The safety and functionality as filling materials were preliminary evaluated after embedded for 1, 2 and 4 weeks, compared with the control samples. Results The xenograft acellular dermal sheets had excellent blood and tissue compatibility, without any immunoreaction;the materials with different thicknesses had different degradation rates which could be utilized by stacking if necessary in application. Conclusion The xenograft acellular dermal sheets can be applied as tissue patch, and are potential to be employed in the fields of plastic and tissue rehabilitation.