Early identification, early diagnosis, early intervention, proper treatment, and the best benefit for patients are the most important manifestations of the ability and quality in large general hospitals. Based on the practical experience of West China Hospital of Sichuan University, we initially sorted out the basic model of multi-disciplinary treatment/multi-disciplinary team (MDT) for the management of patients with coronavirus disease 2019. This article introduces the aspects of team building, division of responsibilities, work flow exploration, MDT discussion basic norms sorting, treatment resources, supervision and coordination of main treatment measures. In the context of the epidemic, all these measures are conducive to promote stronger medical quality assurance and more reasonable resource allocation. The implementation of MDT and shared decision-making model during epidemic provide a reference for medical institutions to carry out hospital quality management, and to improve the treatment for the maximum benefit of patients.