From 1972 to 1992, 333 patients underwent operations because of Graves’ disease in our hospital. Histological examination of resected thyroid tissue revealed carcinoma in 8 cases, which accounted for 2.4%(8/333). With reviewing the literatures basing on a lot of literature, we lay emphasis on the clinical feature of the disease, cause of misdiagnosis, and the diagnosis and treatment of the disease are discussed.
Objective To analyze the clinical relationship between primary hyperthyroidism and thyroid carcinoma, and diagnosis and treatment for the combination of the two. Methods The clinical data of 15 patients with primary hyperthyroidism complicated with thyroid carcinoma from January 1998 to December 2008 were retrospectively analyzed. Results Fifteen cases were smoothly discharged. The morbidity was 2.56% (15/585) of primary hyperthyroidism complicated with thyroid carcinoma. There were no operative complications. Five cases showed thyroid nodules and all cases were performed thyroidectomy. Neither hyperthyroidism nor thyroid carcinoma recurred during 9 months to 10 years (average 5.5 years) follow-up.Conclusions The diagnosis of primary hyperthyroidism complicated with thyroid carcinoma is still difficult to be made preoperatively and chiefly depend on postoperative pathology. Rational surgical treatment can result in good effectiveness and better prognosis.
目的 探讨青少年原发性甲状腺功能亢进（甲亢）手术治疗的可行性。方法 本组76例甲亢患者手术麻醉以颈丛神经阻滞加强化为主； 手术方式为甲状腺大部分切除术，切除腺体组织约80%～90%，残留腺体总量约6～8 g。结果 无手术死亡及甲亢危象病例，术后10例（13.2%）发生并发症11例次，经保守治疗后症状消失。术后得到随访（1～15年）的51例患者中有6例于术后5～8年出现甲亢复发，无术后甲状腺功能低下病例。结论 手术治疗青少年甲亢具有快速安全、疗效持久、费用较低、患者愿意接受的特点，临床上是可行的。