【Abstract】ObjectiveTo detect the expression of melanoma antigen-3 gene (MAGE-3) in rectal cancer and explore its relationship with the clinical pathology of rectal cancer and clinical significance in immune therapy. MethodsThe expressions of MAGE-3 in tumor tissue, para-tumor tissue of （5±1） cm from border of tumor tissue, tissue of resection border and polypus were detected by RTPCR. ResultsMAGE-3 expression was positive in 14 of 33(42.42%) samples of rectal cancer, 6 of 33 (18.18%) of paratumor tissue, and 5 of 33 (15.15%) of resection border tissue respectively. No MAGE-3 was detected in 3 polypi. The positive rate of MAGE-3 in tumor tissue was significantly higher than that of the paratumor and resection border tissue (P＜0.05). The expression of MAGE-3 was not related to age, gender, histological type, metastasis to lymph nodes, and Dukes stage (Pgt;0.05). Conclusion MAGE-3 protein may be used as a target of immunotherapy for rectal cancer and an index for follow-up and screening of rectal cancer.
目的探讨腹股沟直疝突入阴囊的可能原因及其手术修补方法。 方法回顾性分析笔者所在医院2005年6月至2013年6月期间收治的353例次腹股沟直疝患者的临床资料。 结果353例次腹股沟直疝患者，发生疝囊突入阴囊12例次，发生率为3.4%。与未突入阴囊组比较，突入阴囊组患者的年龄大、病程长、疝环口及疝囊大，且多伴有慢性支气管炎、便秘等导致慢性腹内压增高的疾患。12例次中采用“疝环充填+平片”修补术1例次，其余11例次均采用腹膜前修补术。术后随访6～60个月，平均37个月，无复发病例。 结论腹股沟直疝在少数情况下可以突入阴囊，宜选择腹膜前间隙疝无张力修补术。