【摘要】 目的 探讨机械法准分子激光角膜上皮瓣下磨镶术（Epi-LASIK）对大视杯高度近视患者的视网膜神经纤维层 （RNFL）的影响。 方法 对2007年1月-2009年1月拟行Epi-LASIK手术的眼底杯盘比gt;0.5的44例44只眼行光相干断层扫描（OCT）检查，测量以视盘为中心、直径为3.4 mm的RNFL厚度， 以象限图分4个区域（上方、下方、颞侧、鼻侧）显示。并分别于手术前及手术后第10 天，1、3 个月，1、2年进行随访。对所测数据进行方差分析。 结果 RNFL厚度测量结果显示， 手术前上方、下方、鼻侧、颞侧RNFL厚度与手术后比较， 差异均无统计学意义（Pgt;0.05）。 结论 Epi-LASIK手术对大视杯近视的RNFL厚度无明显影响。【Abstract】 Objective To investigate the effects of Epi-LASIK on retinal nerve fiber layer (RNFL) thickness in patients with large cup. Methods Forty-four patients (44 eyes) with high myopia from January 2007 to January 2009, whose C /D area ratios were above 0.5, underwent optical coherence tomography(OCT)examination. To measure the RNFL thickness taking optic disk as the center, diameter as 3.4 mm, for quadrant graph as above, below, temporal, lateral. After the operation in the first 10 days, and one, three months, and one, two years after surgery were followed. The data were analyzed by analysis of variance. Results The RNFL thickness at every quadrant had no statistical significant difference between preoperative period and postoperative time(Pgt;0.05). Conclusion Epi-LASIK surgery has no effect on RNFL thickness in high myopic patients with large cup.
ObjectiveTo systematically review the association between migraine and lacunar infarcts on MR image.MethodsPubMed, EMbase, The Cochrane Library, CNKI, VIP and WanFang Data databases were electronically searched to collect randomized controlled trials, cohort studies and cross-sectional studies on the association between migraine and lacunar infarcts from inception to March 2019. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by RevMan 5.3 software.ResultsA total of 5 studies involving 5 104 participants were included. The results of meta-analysis showed that: there were no significant associations of migraine (OR=0.93, 95%CI 0.78 to 1.12, P=0.470) and aura (OR=1.10, 95%CI 0.89 to 1.36, P=0.390) with lacunar infarcts on MR image. Subgroup analysis by age, presence or absence of aura showed no significant tendency.ConclusionsThere is no significant relationship between migraine and lacunar infarcts. Due to limited quality and quantity of the included studies, more high quality studies are required to verify above conclusions.
Objective To evaluate the clinical efficacy and safety of imported and domestic oxiracetam injection in the treatment of acute cerebral infarction. Methods Between March 2013 and July 2014, a multicenter randomized blind controlled clinical study was conducted to learn the clinical efficacy and safety of imported oxiracetam injection (produced by Korea Pharmaceutical Corporation) and domestic oxiracetam injection (named as Oulantong, produced by Harbin Medisan Pharmaceutical Co., Ltd) in the treatment of acute cerebral infarction. West China Hospital of Sichuan University was in charge of the study, and the participants included the People’s Hospital of Guangxi Zhuang Autonomous Region, Affiliated Hospital of Guilin Medical University, Department of Neurology of Jilin Provincial People’s Hospital, the Second Affiliated Hospital of Kunming Medical University, the First Hospital of Lanzhou University, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, the First Affiliated Hospital of Soochow University, the First Affiliated Hospital of Tianjin University of TCM, Chongqing Three Gorges Central Hospital, and the Second Affiliated Hospital of Soochow University. A total of 240 patients with acute cerebral infarction were randomly divided into trial group (basic treatment plus imported oxiracetam injection) and control group (basic treatment plus domestic oxiracetam) with 120 patients in each. Follow-up was conducted 1 week, 2 weeks and 12 weeks after treatment. Finally, 200 patients consistent with the study criteria were included, including 101 in the trial group and 99 in the control group. National Institute of Health Stroke Scale (NHISS), Modified Rankin Scale (mRS) and Barthel Index (BI) were used to evaluate patients’ neurologic impairment, disability degree, life quality and treatment effective rate. Safety indexes included adverse events and life vital signs. Results NHISS scores of the trial group and the control group were respectively (7.46±1.99) and (7.20±2.47) points before the treatment, (5.81±2.30) and (5.54±2.58) points one week after the treatment, (3.93±2.40) and (3.79±2.39) points two weeks after the treatment, (1.85±1.63) and (2.08±2.01) points 12 weeks after the treatment. There was no significant difference between the two groups at all time points (P>0.05). BI and mRS grading were not significantly different between the two groups at all time points after the treatment (P>0.05). NHISS score, mRS grading and BI at each time point after the treatment were significantly different from those before the treatment (P<0.05). No significant differences were found between the two groups in the treatment effective rate at each time point (P>0.05). Fifty patients (41.66%) in the trial group had 111 adverse events (92.50%), and 61 (50.83%) in the control group had 145 adverse events (120.83%). There was no significant difference between the two groups (P>0.05). Moreover, most of the adverse reactions were at a mild degree. Life vital signs two weeks after the treatment were not significantly different between the two groups, either (P>0.05). Conclusion Imported oxiracetam injection is of similar efficacy and safety with domestic Oulantong injection in the treatment of acute cerebral infarction.