west china medical publishers
Author
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Author "唐鹤涵" 4 results
  • Methods and Applications for Quantitative Measurement of Iron in Human

    Objective To summarize the methods and applications for quantitative measurement of iron in human.Methods The methods and applications for quantitative measurement of iron in human were analyzed retrospectively via reviewing the literatures domesticly and abroad, and summarized the advantages and disadvantages respectively. Results The methods for quantitative measurement of iron included laboratory tests, pathology examinations, CT, superconducting quantum interference device investigation (SQUID), and MRI. Conclusions Laboratory test is the most simple and economic method for quantitative measurement of iron in human. Percutaneous liver biopsy is the gold standardmethod. Radiologic examinations, especially MRI, may be main methods of measuring liver iron content in future.

    Release date: Export PDF Favorites Scan
  • MRI常规扫描及弥散加权成像在宫颈癌评价中的价值

    MRI常规扫描凭借着较高的软组织分辨率对宫颈癌肿块在宫颈内部的生长情况、肿块对宫体的侵犯程度以及对宫旁癌周的侵犯、宫旁闭孔区淋巴结转移的评价方面具有较高准确性和特异性。MRI常规扫描可提高宫颈癌的定位、定性、分期的准确性,有助于临床国际妇产科联盟(FIGO)分期。MRI弥散加权成像,作为功能磁共振的一种,是唯一一种可以评价活体组织内水分子弥散状况的扫描方法,利用弥散加权成像获得表观弥散系数值可以对宫颈癌病灶组织病理学类型及分化程度、宫旁侵犯、淋巴结转移进行定量定性分析。将弥散加权成像与常规扫描结合起来在诊断宫颈癌、协助临床FIGO分期、制订优化个体化治疗方案及预后预测上有较大临床应用价值。

    Release date: Export PDF Favorites Scan
  • Value of Gd-BOPTA Enhanced MR in Diagnosing Hepatocellular Carcinoma with Correlation of Pathology

    Objective To investigate the value of new double-phasic MR contrast agent (gadobenate dimeglumine, Gd-BOPTA) in diagnosis of hepatocellular carcinoma (HCC) with correlation of pathology. Methods MRI scan was performed on 33 patients suspected of having focal liver lesions by CT or ultrasonography. The MRI scan protocol included routine axial T1WI and T2WI, coronal T2WI and 3D-MRCP, Gd-BOPTA enhanced 3D gradient-echo sequence of T1W (LAVA sequence) acquiring dynamic data at 15 s, 55 s and 90 s respectively, delayed LAVA acquisition at 5 min, 10 min, and at 40 min, 80 min respectively. Surgical specimen was collected for pathological analysis.  Results Surgery confirmed the diagnosis of HCC in 21 patients with 27 lesions. The sensitivity, specificity and accuracy of MR imaging with combined phases (including hemodynamic phase and hepatobiliary phase) were 92.9%,93.3%, 92.9% respectively. ①In the hemodynamic phase: 22 lesions showed early enhancement in arterial phase, fast “washout” in portal venous phase, and hypointense in delayed phase. Four lesions showed slight enhancement, while 1 lesion showed no enhancement in all hemodynamic phases. ②In the hepatobiliary phase: 23 lesions showed homogeneous hypointensity compared to the enhanced liver background, but 4 lesions (3 well-differentiated and 1 moderately-differentiated) had patchy or dot-like slightly hyperintense areas scattered within the lesions. Pathologically cholestatic changes of tumor cells were observed and bile-containing small ducts were present. Conclusion Gd-BOPTA enhanced MRI can both depict the hemodynamic characteristics and reflect the absence of normal hepatocyte function in HCC lesions, thus contributing greatly to the diagnosis of HCC.

    Release date:2016-09-08 11:49 Export PDF Favorites Scan
  • Value of Gd-BOPTA Enhanced MR Imaging in Diagnosing Focal Nodular Hyperplasia of Liver (Report of 5 Cases)

    Objective To investigate the value of a new double action MR contrast agent——Gd-BOPTA in the diagnosis of focal nodular hyperplasia (FNH) of the liver with correlation of pathology. Methods Dedicated MRI scans were performed for 5 patients suspected to have liver FNH on clinical and imaging basis (six lesions). The MR imaging protocol included axial T1W and T2W plain scan, coronal T2 weighted imaging, 3D MRCP, Gd-BOPTA enhanced LAVA dynamic tri-phasic acquisitions (scanning at 15 s, 55 s and 90 s respectively), enhanced 2D T1W scan, enhanced LAVA in delay phase (at 5 and 10 min) and in the hepatobiliary phase (at 40 and 80 min). The imaging features on each MR sequence were compared with surgical and pathological findings. Results Six lesions in 5 FNH patients were all correctly diagnosed (5 conformed by surgery and 1 by needle biopsy). ①The hemodynamic phase: The parenchyma of 5 lesions were markedly enhanced in the arterial phase, being isointense or slight hypointense in both the portal venous and delay phases, while 1 lesion was isointense in all phases except being slight hyperintense in the arterial phase; The central scar of 5 lesions were not enhanced in the dynamic phase, but showed delayed enhancement. ②The hepatobiliary (excretory) phase: The parenchyma of all 6 lesions were slight hyperintense or isointense, and tree-like bile ducts with hyperintensity were seen within one lesion. The scar showed no enhancement. ③Pathology: The parenchyma was consisted of disarranged normal hepatocytes but with cytoedema, lack of portal tracts and cholestatic change. The central scar showed rich fibrous tissue, a very thick-walled arteriole, proliferative bile ducts, infiltration of inflammatory cells and myxomatous changes. Conclusion As a dual-phase MR contrast agent capable of depicting both the hemodynamic attributes and hepatobiliary excretion, Gd-BOPTA enhanced MRI can reflect the pathological features of FNH and reach a high diagnostic accuracy.

    Release date:2016-09-08 11:49 Export PDF Favorites Scan
1 pages Previous 1 Next

Format

Content