目的:分析基底细胞癌中P53蛋白的表达情况,探讨P53蛋白的表达与基底细胞癌发生发展的关系,以及在基底细胞癌发病机制中的作用。方法:选取2006年7月至2007年2月,北京朝阳医院皮肤科手术切除的基底细胞癌及正常皮肤组织石蜡标本各17例,免疫组织化学法分析P53蛋白在基底细胞癌和正常皮肤组织中的表达情况。结果:17例基底细胞癌中P53蛋白的表达率为100%。综合染色强度和阳性细胞所占比例进行平均半定量分析,P53蛋白在基底细胞癌中表达程度为,而在正常皮肤组织中表达程度为+,两者之间存在统计学上显著性差异。结论:P53在基底细胞癌中呈现高度表达状态,提示P53蛋白的表达与基底细胞癌的发病过程关系密切,可能在其发生发展过程中起重要作用。
目的:观察Nd:YAG激光治疗基底细胞癌的临床治疗效果。方法:患者经病理确诊为基底细胞癌后予Nd:YAG激光局部治疗,去除皮损。结果:12例患者经Nd:YAG激光治疗后5例治愈,7例显效,有效率达100%,5年随访期内均无复发。结论:Nd:YAG激光能有效地治疗基底细胞癌。
Objective To investigate the effectiveness of nasolabial flap and ear cartilage in repairing defects after nasal ala basal cell carcinoma resection. Methods Between January 2012 and August 2014, 8 patients with nasal ala basal cell carcinoma underwent tumor resection and defect repair with nasolabial flap and ear cartilage. Among the 8 patients, 5 were male and 3 were female, with an average age of 65 years (range, 45-76 years). The left side and right side were involved in 3 cases and 5 cases respectively. Carcinoma confirmed by pathological examination in all patients. The time between first biopsy and resection was 7-14 days (mean, 10 days). The defect ranged from 1.5 cm×1.5 cm to 2.0 cm×1.5 cm after tumor resection, and the size of nasolabial flaps ranged from 4.0 cm×1.5 cm to 5.0 cm×2.0 cm. The operations of cutting off the pedicle and thinning skin flap were performed at 6 months after first operation. Results All flaps survived. Incisions healed by first intention, and no related complication occurred. No carcinoma recurred after cutting off the pedicle. All patients were followed up for 6 months. All patients were satisfied with the nasal contour, symmetrical projection of the alar dome, and no obvious scar. Conclusion Nasolabial flap transfer and ear cartilage transplant method not only can repair the nasal ala defects, but also can avoid obvious scar and obtain good nasal ala contour profile. The shortcoming is that patients have to receive two operations.