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Research Progress of Esophageal Cancer Stem Cells

Esophageal carcinoma is a kind of common malignant tumor in the digestive tract. Although a lot of basic researches and clinical trials have been carried out all over the world, neither the diagnostic level nor the therapeutic effects have been obviously improved. The 5-year survival rate of esophageal cancer patient is still lower than that of other malignant tumors. Up to now, some frontier researches consider that the reason of the esophageal carcinoma being difficult to cure is related to the stem cells in it. Elimination or suppression of these stem cells may bring new hope for the treatment of esophageal cancer. This article generally introduces the specific markers, separation and indentification methods about the esophageal cancer stem cell. The targeted therapy is also mentioned.

医用胶在肺微小结节术前定位中的应用

目的探讨医用胶用于肺微小结节术前定位的临床价值。方法2013 年 3 月至 2015 年 3 月兰州大学第二医院胸外科 25 例患者的 28 处肺内微小结节病灶经术前定位后行胸腔镜手术切除，其中男 18 例、女 7 例，年龄 23～67（43.00±3.54）岁。所有患者均在 CT 引导、局部麻醉下用 23G 穿刺针行经皮肺穿刺注射医用胶进行肺结节定位。定位当日或次日行胸腔镜手术切除。结果全组 28 处肺内微小结节病灶直径 0.42～1.34（0.82±0.12）cm，距离脏层胸膜 1.51～3.26（2.31±0.42）cm，均成功实施经皮肺穿刺并于结节周围注射医用胶，定位成功率 100.0%。定位并发症包括无症状气胸 5 例，疼痛 2 例，均不需特殊处理。术前定位后，肺内微小结节的切除成功率为 100.0%，其中 2 例因结节同肺内动脉、支气管毗邻而直接行肺叶切除术。术后病理提示原发性肺癌 12 例，结核瘤 8 例，机化性肺炎 2 例，转移癌、错构瘤、肺内淋巴结各 1 例。结论医用胶术前定位肺内微小结节是一种安全、有效、简单的方法，定位后可提高胸腔镜下肺内微小结节的手术切除率。

食管癌术后继发梨状窝癌一例