Objective To study the expressions of SKP2 and p27 in gastric carcinoma and pericancerous tissues and to detect the relationship between their expressions and clinicopathological features. Methods Forty-nine cases of gastric carcinoma spicemen and 20 cases of tissue adjacent to the carcinoma were cut and made into paraffin-embedded slices. The expressions of SKP2 and p27 were then detected by SP immunohistochemical method. Results The positive expression rate and score of SKP2 were both significantly higher in the gastric carcinoma tissues than those in pericancerous tissues (P＜0.01), whereas those terms of p27 were higher in pericancerous tissues (P＜0.05, P＜0.01). It was observed that the pericancerous tissues with positive SKP2 expression or with negative p27 expression showed atypical hyperplasis ranging from moderate to severe degrees. The positive rate and score of SKP2 were significantly lower in the cases of infiltrating depth T1+T2， without-metastasis of lymph node, with-metastasis of the first site lymph node, and without-metastasis of distant organs than those in infiltrating depth T3+T4, with-metastasis of lymph node, with-metastasis of the second or third site lymph node and with-metastasis of distant organs in gastric carcinoma tissues (P＜0.05， P＜0.01), whereas the results were contrary for p27 (P＜0.01). There was a negative correlation between the score of SKP2 and that of p27 in gastric carcinoma tissues (r=-0.65, P＜0.01). Conclusion The expressions of SKP2 and p27 may act as important biological markers to reflect carcinogenesis, progression, biological beheviors and prognosis of gastric carcinoma.
目的 探讨十二指肠腺瘤并大出血的诊断和治疗。方法 对2例十二指肠腺瘤并大出血患者进行回顾性分析，并结合文献进行讨论。结果 2例术前均行X线气钡双重造影、胃镜及肿块活检，但未确诊。2例均行十二指肠切开、肿瘤切除术而痊愈。结论 十二指肠腺瘤早期多无临床症状，随着肿瘤的增大可并发肠梗阻或肿瘤溃疡出血而出现相应症状； X线钡餐和胃镜可发现肿瘤，但难于确诊，经内窥镜或十二指肠切开、肿瘤切除术是治疗本病的常用方法。