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find Author "姜荆" 2 results
  • 阿戈美拉汀对癫痫共病偏头痛患者的治疗潜力

    与一般人群相比,癫痫患者偏头痛的患病率通常高于正常水平,反之亦然。偏头痛和癫痫也具有更高的焦虑和抑郁的患病率和发生率。神经元网络的过度兴奋是偏头痛和癫痫的共同病理机制。睡眠障碍可以导致癫痫及头痛的发生。褪黑激素(Melatonin,MT)是松果体分泌的一种内源性激素,具有昼夜节律特性,在癫痫中具有重要作用。作为MT1和MT2受体激动剂以及 5-羟色胺2C(5- Hydroxytryptamine 2C,5-HT2C)受体拮抗剂,阿戈美拉汀是一种新型抗抑郁药,其具有改善昼夜节律、减少去极化导致的谷氨酸释放、强大的神经保护作用、抗炎及可能的抗氧化特性可能使其成为治疗癫痫共病偏头痛的潜在药物。

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  • The application progress of focal cortical stimulation in drug-resistant focal epilepsy

    Approximately 70 million people worldwide suffer from epilepsy, with about 9 million in China. About one-third of patients demonstrating resistance to traditional antiseizure medications (ASMs), Focal Cortical Stimulation (FCS) emerges as a novel neuromodulation therapy based on neural stimulation, showing potential in treating drug-resistant focal epilepsy. FCS reduces seizure frequency by diminishing abnormal excitability in cortical areas. Compared to traditional surgery, it carries lower risks and is particularly suited for patients whose epileptogenic foci are difficult to surgically localize. Its adjustability provides physicians with treatment flexibility, allowing them to tailor therapy based on patient conditions. Recent studies highlight the practical clinical application of FCS, underscoring its advantages in reducing the frequency of drug-resistant epilepsy seizures. The article concludes by exploring the future prospects of FCS, emphasizing the need for research in long-term efficacy assessment and patient adaptability, thus demonstrating its significant potential and direction for development in the field of epilepsy treatment.

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