【摘要】 目的 探讨左炔诺孕酮宫内释放系统联合桂枝茯苓胶囊治疗子宫腺肌病的疗效。 方法 2006年2月-2010年2月108例子宫腺肌病患者随机分为观察组（n=56）与对照组（n=52），观察组患者宫内放置左炔诺孕酮宫内释放系统，同时口服中成药桂枝茯苓胶囊，3粒/次，3次/d，连服6个月。对照组单放置左炔诺孕酮宫内释放系统进行治疗，观察月经量、痛经程度、子宫体积及血清CA125水平变化。 结果 6个月后，观察组患者痛经明显缓解，月经量显著减少，子宫体积缩小，血清CA125水平明显降低，治疗前后比较，差异均有统计学意义（Plt;0.05）；与对照组比较，痛经评级、子宫体积缩小、血清CA125水平差异均有统计学意义（Plt;0.05）。 结论 左炔诺孕酮宫内释放系统与桂枝茯苓胶囊联合治疗子宫腺肌病安全有效，满意度高，值得临床推广应用。【Abstract】 Objective To evaluate the therapeutic effect of levonorgestrel-releasing intrauterine system (LNG-IUS) combined with Guizhi Fulin capsules treating adenomyosis. Methods A total of 108 patients with adenomyosis diagnosed in our hospital from February 2006 to February 2010 were randomly divided into the observation group (n=56) and the control group (n=52). The patients in the observation group were treated with LNG-IUS and simultaneously administrated orally with the Guizhi Fulin capsules (three capsules per time, three times per day for six continuous months). The patients in the control group were treated with LNG -IUS only. The changes of the menstrual blood volume, severity of dysmenorrhea, uterine volume and the level of serum CA125 were observed and evaluated. Results After six months’ treatment, dysmenorrhea of all the patients was obviously alleviated, the menstrual blood volume reduced significantly, the uterine volume shrank, and the level of serum CA125 decreased significantly; the results after the treatment differed much from that before the treatment (Plt;0.05). Compared with those in the control group, the differences in the grades of the dysmenorrheal, shrinkage of the uterine volume and the level of serum CA125 were statistically significant (Plt;0.05). Conclusion Combined usage of LNG-IUS and Guizhi Fulin capsules is an effective and safe way treating adenomyosis.
目的 观察消化道肿瘤患者服用甲羟孕酮（medroxyprogesterone acetate, MPA）对化疗后骨髓抑制的影响。 方法 2008年11月-2009年8月，将接受化疗的消化道肿瘤患者共100例随机分为治疗组(MPA加化疗组，54例)及对照组(单纯化疗组，46例)，2周期化疗后评价骨髓抑制状况和生活质量变化。 结果 治疗组和对照组化疗后白细胞、血红蛋白和血小板Ⅰ~Ⅱ度骨髓抑制发生率没有差异（Pgt;0.05），但治疗组Ⅲ~Ⅳ度骨髓抑制发生率低于对照组，KPS评分改善率高于对照组（Plt;0.05）。未见明显不良反应。 结论 MPA可有效减轻化疗后骨髓抑制。
目的:观察醋酸甲地孕酮(MA)在预防化疗引起的消化道反应中的作用。方法:收集2007年6月～2008年6月病理学和细胞学证实的消化道恶性肿瘤60例,采用自身前后交叉对照研究,随机分为AB和BA两组。AB组第一周期止吐方案用格拉司琼+胃复安＋MA,第二周期止吐方案用格拉司琼+胃复安;BA组第一周期止吐方案用格拉司琼+胃复安,第二周期止吐方案MA＋格拉司琼+胃复安。结果:化疗同时配合使用MA恶心、呕吐发生率下降(Plt;0.05);恶心、呕吐程度改善(P.001),并且可以预防化疗引起的急性期和延迟期恶心、呕吐反应(Plt;0.05)。结论:化疗同时配合使用MA可以改善化疗患者的恶心呕吐反应
Objective To review the mechanisms of cholesterol gallstones caused by female hormone so as to explore new treatments to prevent gallstones associated with estrogen and progesterone. Methods The literatures on gallstones related with female hormone were reviewed and the mechanisms of cholesterol gallstones were summarized. Results The cholesterol gallstones mechanisms was affected by estrogen through genomic effects，and the nucleation of cholesterol was promoted by estrogen through nongenomic，which resulted in the formation of cholesterol gallstones. And the bile empty dysfunction associated with estrogen through nongenomic effects was also the reason of cholesterol gallstone formation. The G proteins α subunit responsible for the motility of gallbladder were disrupted by progesterone through genomic effects，and the ionic channels and signal transduction were also interfered through nongenomic pathway，which impaired the contraction of gallbladder. However，the nongenomic effects might not play an important role in the gallstones formation caused by progesterone. Conclusions The mechanisms of cholesterol gallstones formation associated with female hormone are complicated，the understanding of chelesterol gallstones formation mechanisms might be helpful to prevent gallstones associated with estrogen and progesterone.