【Abstract】ObjectiveTo investigate the effects of cholecystokinin （CCK） on diabetes mellitus with cholecystolithiasis. MethodsRelevant literatures of recent years were reviewed. ResultsCCK exists widely in human body．On the one hand, CCK enhances cholecystolithiasis by causing diabetes. On the other hand, its pathological changes can also lead to cholecystolithiasis. Besides, it is possibility that the CCKrelated gene abnormality is the common cause of diabetes and cholecystolithiasis. ConclusionCCK plays an important role in diabetes mellitus complicated with cholecystolithiasis. However, there is much yet to be known about CCK．
目的探讨腹腔镜胆囊切除术(LC)后并发出血的原因与正确的防治方法。方法对1992年10月至2005年2月我院进行的LC术后并发出血的37例患者的临床资料进行回顾性分析。结果胆囊动脉出血21例，胆囊床出血4例，网膜出血6例，trocar穿刺孔出血4例，不明出血部位2例。直接开腹手术7例，腹腔镜再次手术止血并获成功21例，腹腔镜止血失败中转开腹手术4例，非手术止血成功5例。36例顺利恢复出院，死亡1例。随访36例（其中失访1人），恢复良好。结论LC术后并发出血的原因多种多样，但多为胆囊动脉出血； 治疗以腹腔镜再次探查止血为主，但不能忽视非手术治疗的重要性。
目的 探讨腹腔镜下胆囊管结石的处理方法及并发症的预防。方法在2002年5月至2005年5月期间施行腹腔镜胆囊切除术（LC） 6 220例，其中胆囊管结石265例，对此进行回顾性分析。结果顺利完成LC 256例，中转开腹9例，无胆管损伤、出血、胆囊管残余结石病例的发生，2例出现胆瘘，经引流后治愈。结论严格规范的操作,良好显露胆囊三角,辨清肝总管、胆总管和胆囊管之间的关系,是正确处理胆囊管结石的关键。
【 Abstract 】 Objective To investigate the cause, management and prevention of biliary fistula with un-typical after laparoscopic cholecystectomy (LC). Methods Twenty-one cases of biliary fistula with un-typical after LC were reviewed retrospectively. Results All patients displayed with un-typical expression and had no obvious signs of peritonitis. Lump of right upper quadrant (6 cases) ， vague pain of epigastric zone (11 cases) ， abdominal distention (3 cases) and bowel obstruction (1 case) after operation were main manifestations. Abdominal paracentesis (14 cases) ， bile exuded from incisional opening of trocar (6 cases) and exploratory laparotomy (1 caes) were the methods of final diagnosis. The cause of biliary fistula included cystic stump fistula (2 cases) ， aberrant bile-duct fistula (9 cases) ， and accessory hepatic duct fistula (4 cases). Laparoscopic approach and puncturation and drainage under ultrasound were the main therapeutic methods. All patiens were discharged successfully with no death case. Nineteen cases were followed up for 3 months to 2 years, and all patients recovered very well. Conclusion The biliary fistula with un-typical after LC is scarce ， and it can lead to missed diagnosis and treatment. Strengthening recognition of biliary fistula after LC ， and paying attention to chief complaint and abdominal sign can help discover biliary fistula early. Laparoscopic approach and puncturation under ultrasound are the recommended therapeutic methods.